Screening of Molecular Targets of Action of Atractylodin in Cholangiocarcinoma by Applying Proteomic and Metabolomic Approaches [PDF]
Metabolites, 2019 Cholangiocarcinoma (CCA) is cancer of the bile duct and the highest incidence of CCA in the world is reported in Thailand. Our previous in vitro and in vivo studies identified Atractylodes lancea (Thunb) D.C.
Kesara Na-Bangchang +2 more
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Atractylodin Inhibits Interleukin-6 by Blocking NPM-ALK Activation and MAPKs in HMC-1 [PDF]
Molecules, 2016 Atractylodin is one of the major constituents of the rhizome of Atractylodes lancea, which is widely used in Korean traditional medicine as a remedy for the treatment of gastritis and gastric ulcers.
Young-Won Chin +2 more
exaly +5 more sources
Natural Potent NAAA Inhibitor Atractylodin Counteracts LPS-Induced Microglial Activation [PDF]
Frontiers in Pharmacology, 2020 N-acylethanolamine-hydrolyzing acid amidase (NAAA) is a lysosomal enzyme that inhibits the degradation of palmitoylethanolamide (PEA), an endogenous lipid that induces analgesic, anti-inflammation, and anti-multiple sclerosis through PPARα activation ...
Yan Qiu, Fan Hu, Haiping Zhang
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The combined influence of microbiome and soil environment contributes to the chemotype differentiation in Atractylodes lancea [PDF]
iMetaOmicsAtractylodes lancea, a traditional Chinese medicinal herb, is divided into two chemotypes based on the production of volatile bioactive compounds: the geo‐authentic Maoshan chemotype (MSA, rich in atractylon and atractylodin) and the non‐authentic Hubei ...
Hongyang Wang +14 more
doaj +3 more sources
Atractylodin modulates ASAH3L to improve galactose metabolism and inflammation to alleviate acute lung injury [PDF]
iScienceSummary: Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) has good anti-inflammatory activity and protects the integrity of the epithelial cell barrier ...
Kun Shi +7 more
doaj +4 more sources
Journal of Pharmacological Sciences, 2018 Cholangiocarcinoma (CCA) is the cancer of bile duct with high mortality rate particularly in Thailand. The clinical efficacy of the standard chemotherapeutics remains unsatisfactory, and therefore, discovery and development of the new alternative drugs ...
Kesara Na-Bangchang +2 more
exaly +5 more sources
Atractylodin Ameliorates Colitis via PPARα Agonism [PDF]
International Journal of Molecular Sciences, 2023 Atractylodin is a major compound in the rhizome of Atractylodes lancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. Recent studies have shown that atractylodin exerts anti-inflammatory effects in various inflammatory diseases.
Gwangbeom Heo, Jee H Jung, Eunok Im
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Effects of atractylodin and β-Eudesmol on P-glycoprotein and Caco-2 cells permeability
Phytomedicine PlusBackground: Atractylodin and β-eudesmol are the major constituents of Atractylodes lancea (Thunb.) D.C. (AL) which have been demonstrated potential activities against cholangiocarcinoma in a series of in vitro and in vivo studies.
Kesara Na-Bangchang
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Atractylodin ameliorates bleomycin-induced pulmonary inflammation and fibrosis in mice
Pharmacological Research - Modern Chinese Medicine, 2023 Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease. The commonly used drugs for the treatment of pulmonary fibrosis can only delay the damage of lung function but cannot prolong the life of patients. Atractylodin (ATR), a
Zhenhui Wu +11 more
doaj +2 more sources
Authenticating the geographic origins of Atractylodes lancea rhizome chemotypes in China through metabolite marker identification [PDF]
Frontiers in Plant Science, 2023 IntroductionAtractylodes lancea is widely distributed in East Asia, ranging from Amur to south-central China. The rhizome of A. lancea is commonly used in traditional Chinese medicine, however, the quality of products varies across different regions with
Chengcai Zhang +12 more
doaj +2 more sources