Results 61 to 70 of about 24,092 (167)

Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study

Journal of Translational Medicine, 2012
Background High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined.
Flores Roberto, Shi Jianxin, Fuhrman Barbara, Xu Xia, Veenstra Timothy D, Gail Mitchell H, Gajer Pawel, Ravel Jacques, Goedert James J   +8 more
doaj   +1 more source

In Vitro Metabolism of Δ8‐, Δ9‐, and Δ10‐THC in Human Hepatocytes: Distinct Δ10‐THC Biotransformation and Implications for Drug Testing

Drug Testing and Analysis, EarlyView.
Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand, Henrik Green, Markus Loh, Fabian Rüttimann, Manuela Carla Monti   +4 more
wiley   +1 more source

Unique β-Glucuronidase Locus in Gut Microbiomes of Crohn's Disease Patients and Unaffected First-Degree Relatives.

PLoS ONE, 2016
Crohn's disease, an incurable chronic inflammatory bowel disease, has been attributed to both genetic predisposition and environmental factors. A dysbiosis of the gut microbiota, observed in numerous patients but also in at least one hundred unaffected ...
Karine Gloux, Jamila Anba-Mondoloni
doaj   +1 more source

Identification of Synthetic Urine by Analysis of Stable Carbon and Nitrogen Isotope Ratios and Comparison to Established GC‐MS/MS and LC‐MS/MS Analysis

Drug Testing and Analysis, EarlyView.
This study compared GC‐MS/MS, EA‐IRMS, and LC‐MS/MS for detecting synthetic and manipulated urine samples in doping control and forensic analysis. EA‐IRMS proved particularly effective for identifying mixtures of synthetic and authentic urine, providing a reliable complement to established authenticity testing methods.
Frank Hülsemann, Laura Franke, Dirk K. Wissenbach, Gregor Fußhöller, Mario Thevis   +4 more
wiley   +1 more source

High-throughput β-galactosidase and β-glucuronidase Assays Using Fluorogenic Substrates

Bio-Protocol, 2013
β-galactosidase and β-glucuronidase enzymes are commonly used as reporters for gene expression from gene promoter-lacZ or uidA fusions (respectively). The protocol described here is a high-throughput alternative to the commonly used Miller assay (Miller,
Josh Ramsay
doaj   +1 more source

Presence of benznidazole conjugated metabolites in urine identified by β-glucuronidase treatment

Brazilian Journal of Pharmaceutical Sciences, 2020
Chagas disease is a serious public health problem in Latin America and, due to migration, in other non-endemic regions. Benznidazole (BNZ) is first choice drug in pediatric therapeutics. However, little is known regarding its metabolism in humans.
María Elena Marson, Facundo García Bournissen, Jaime Altcheh, Guillermo Moscatelli, Samantha Moroni, Guido Enrique Mastrantonio   +5 more
doaj   +1 more source

Measuring Faecal Epi-Androsterone as an Indicator of Gonadal Activity in Spotted Hyenas (Crocuta crocuta). [PDF]

PLoS ONE, 2015
Enzyme immunoassays (EIA) that measure faecal testosterone metabolites (fTM) are useful tools to monitor gonadal activity. The aim of this study was to validate an "in-house" epiandrosterone EIA to monitor fTM in spotted hyenas. FTM were characterised in
Susanne Pribbenow, Marion L East, Andre Ganswindt, Adrian S W Tordiffe, Heribert Hofer, Martin Dehnhard   +5 more
doaj   +1 more source

Biomass‐derived hydrochars as eco‐friendly adsorbents for wastewater treatment applications

Environmental Progress &Sustainable Energy, EarlyView.
Abstract Emerging organic pollutants (EOPs), such as diethyl phthalate (DEP), bisphenol A (BPA), and methylene blue (MB), are only partially removed in conventional wastewater treatment plants. This study assesses hydrochars produced by hydrothermal carbonization (HTC) of spruce bark (SB), vine shoots (VSs), and wheat straw (WSs) for removing three ...
Emanuel Gheorghita Armanu, Sara Ribeirinho‐Soares, Christian Eberlein, Hermann J. Heipieper, Irina Volf, Olga C. Nunes, Olívia Salomé G. P. Soares   +6 more
wiley   +1 more source

Sexual dimorphism in hormone–gut microbiome associations across reproductive states in wild giant pandas

iMetaOmics, EarlyView.
Gut microbiota–host endocrine interactions in wild mammals remain poorly understood. Giant pandas experience seasonal dietary shifts and constrained annual reproduction, offering an ideal model to investigate microbiome–endocrine coupling. We integrated fecal hormone profiling, microsatellite‐based individual identification, and gut microbiome ...
Qinlong Dai, Xinyuan Cui, Chenyi Gao, Xiaoxiao Tang, Kaizhi Wen, Minhui Shi, Chen Zhang, Yue Liu, Xinru Yang, Qiuyu Huang, Lifeng Zhu   +10 more
wiley   +1 more source

The role of human microbiota in breast cancer pathogenesis and treatment

iMeta, EarlyView.
The human microbiota contributes to breast cancer pathogenesis and treatment response through interactions involving the oral, gut, and breast microbial niches. (Left) Multi‐site dysbiosis is characterized by altered microbial composition and abundance across different anatomical sites.
Jie Qiu, Xiaojia Wang, Man Li, Jing Guo, Shipeng Ning, Yi‐Zhou Gao, Xinyi Zhang, Xuli Meng, Yiding Chen, Yunxiang Zhou   +9 more
wiley   +1 more source