Results 281 to 290 of about 1,516,213 (305)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

Carboxyl‐Terminal Region of the Maturation Protein of RNA Coliphage Qβ Mediates Host Attachment, Virion Formation, and Cell Lysis

Genes to Cells, Volume 31, Issue 2, March 2026.
The capsid of the single‐stranded RNA coliphage Qβ has a maturation (A2) protein that penetrates the capsid. The N‐terminal β‐region of A2 is exposed on the surface, and the C‐terminal α‐region is located inside the capsid and binds the genomic RNA. In this study, we showed that Qβ attached to the F‐pilus of the host via A2.
Masayuki Kajitani, Noriko Hakoshima, Yoshio Inokuchi   +2 more
wiley   +1 more source

Investigation of the assembly mechanism and molecularlevel structure of β-hairpin peptide hydrogelators

Katelyn Nagy-Smith
openalex   +2 more sources

APE1 Activity is Controlled by Non‐G‐Quadruplex Conformations in Single‐ and Double‐Stranded G‐Quadruplex Constructs

Chemistry – A European Journal, Volume 32, Issue 5, 2 February 2026.
G‐quadruplex (G4) folding in DNA is inhibitory to AP endonuclease, although the protein still binds well to G4s. Curiously, partially folded G‐rich sequences, possibly transient hairpins, containing AP are very good substrates for cleavage by APE1. Herein, the enzyme activity and G4 folding are studied in single‐stranded vs. duplex contexts.
Brianna L. Trabucco, Aaron M. Fleming, Cynthia J. Burrows   +2 more
wiley   +1 more source

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

FEBS Open Bio, Volume 16, Issue 2, Page 279-298, February 2026.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey, Lina Riegler‐Berket, Monika Oberer   +2 more
wiley   +1 more source

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Nanoparticle Conjugation Stabilizes and Multimerizes β-Hairpin Peptides to Effectively Target PD-1/PD-L1 β-Sheet-Rich Interfaces.

Journal of the American Chemical Society, 2020
β-hairpin peptides present great potential as antagonists against β-sheet-rich protein surfaces, of which wide and flat geometries are typically 'undruggable' with small molecules.
Woo-jin Jeong, J. Bu, Yanxiao Han, A. Drelich, Ashita Nair, P. Král, Seungpyo Hong   +6 more
semanticscholar   +1 more source

Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles.

Small, 2020
Novel antimicrobial peptides (AMPs) have revolutionarily evolved into formidable candidates for antibiotic substitute materials against pathogenic infections.
Changxuan Shao, Yongjie Zhu, Qiao Jian, Zhenheng Lai, P. Tan, Guoyu Li, A. Shan   +6 more
semanticscholar   +1 more source

Hetero-oligomeric Amyloid Assembly and Mechanism: Prion Fragment PrP(106-126) Catalyzes the Islet Amyloid Polypeptide β-Hairpin.

Journal of the American Chemical Society, 2018
Protein aggregation is typically attributed to the association of homologous amino acid sequences between monomers of the same protein. Coaggregation of heterogeneous peptide species can occur, however, and is implicated in the proliferation of seemingly
Alexandre I Ilitchev, Maxwell J. Giammona, Carina Olivas, S. Claud, Kristi L Lazar Cantrell, Chun Wu, S. Buratto, M. Bowers   +7 more
semanticscholar   +1 more source