Results 91 to 100 of about 18,697 (186)

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, EarlyView.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Prospective evaluation of the Simple Fetal Medicine Foundation's first‐trimester prediction model for preeclampsia in twin pregnancies

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
The Simple Fetal Medicine Foundation model effectively predicts preeclampsia (PE) in twin pregnancies at 11 +0–13 + 6 weeks using only maternal risk factors and mean arterial pressure. It achieves a high detection rate for early onset PE (area under the receiver operating characteristic curve 0.911 for PE <30 weeks) and provides a simple, convenient ...
Cuilian Liu, Jiaxin Li, Yang Chen, Tianchen Wu, Qingnan Meng, Kuo Zhang, Yuan Wei   +6 more
wiley   +1 more source

Potential Mediators of Efpeglenatide's Cardiovascular Benefit: An Exploratory Analysis of the AMPLITUDE‐O Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims In the AMPLITUDE O trial, efpeglenatide reduced major cardiovascular events by 27% in 4076 individuals with Type 2 diabetes and established cardiovascular or kidney disease compared to placebo during a median follow‐up of 1.81 years. This exploratory mediation analysis evaluates the degree to which changes in measured clinical variables ...
Daniel Raaschou‐Oddershede, Christine R. Schwarz, Tanya Kovalova, Kelley R. Branch, Stefano Del Prato, Carolyn S. P. Lam, Renato D. Lopes, Richard Pratley, Julio Rosenstock, Naveed Sattar, Hertzel C. Gerstein   +10 more
wiley   +1 more source

A Highly Powered Large Outcomes Randomised Controlled Trial Will Usually, but Not Always, Have Balanced Groups at Baseline

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective The importance of randomised trials for discerning an intervention's effect rests on randomisation's ability to create groups with (on average) equal hazards of future outcomes. The frequency with which this does not occur in well‐designed large trials with a high event rate was studied.
Hertzel C. Gerstein, Zayeeda Labiba, Sibylle Hess, Kamel Mohammedi, Yueci Zhou, Shun Fu Lee   +5 more
wiley   +1 more source

Levels of serum β‐human chorionic gonadotropin after embryo transfer and subsequent miscarriage, pre‐eclampsia, and intrauterine growth restriction

Health Science Reports
Background This study aimed to examine maternal serum concentration of β‐human chorionic gonadotropin (β‐hCG) on Day 16 after embryo transfer and risk of miscarriage, pre‐eclampsia, and intrauterine growth restriction (IUGR).
Roya Kabodmehri, Nasrin Ghanami Gashti, Ziba Zahiri Sorouri, Seyedeh Hajar Sharami, Forozan Milani, Marziyeh Hasanpour, Habib Eslami‐Kenarsari, Zahra Rafiei Sorouri   +7 more
doaj   +1 more source

Age of Type 1 Diabetes Onset and Dementia Risk: A Swedish Nationwide, Register‐Based Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Individuals with Type 1 diabetes are at a higher risk of dementia compared to individuals without diabetes. Younger age at Type 1 diabetes onset has been linked to an increased risk of cardiovascular disease and higher mortality. This study aimed to determine whether younger age at Type 1 diabetes onset was also associated with all‐cause ...
Milena Jancev, Björn Eliasson, Geert Jan Biessels, J. Hans DeVries, Erik H. Serné, Frank L. J. Visseren, Araz Rawshani, Aidin Rawshani, Tali Cukierman‐Yaffe, Naveed Sattar, Hertzel C. Gerstein, Thomas T. van Sloten   +11 more
wiley   +1 more source

Ruptured Ectopic Pregnancy Misdiagnosed with Ruptured Corpus Luteum: A Case Report and Literature Review

Gynecology and Minimally Invasive Therapy
Ectopic pregnancy can be mistakenly reported as a ruptured corpus luteum. A 22-year-old woman was initially misdiagnosed with a ruptured corpus luteum and treated with analgesics at a local clinic.
Wing Yu Sharon Siu, Dah-Ching Ding
doaj   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Analysis of Clinical Effect and Influencing Factors for Conservative Treatment in Ectopic Pregnancy

Clinical and Experimental Obstetrics & Gynecology
Background: The curative effect of four different kinds of conservative treatment of ectopic pregnancy (EP) and the risk factors affecting the curative effect of conservative treatment of ectopic pregnancy were compared and analyzed.
Huan Xia, Huimin Tang, Qiucheng Jia, Yao Chen, Wulin Shan, Wenying Liu, Cuiying Su, Jiming Chen   +7 more
doaj   +1 more source