Results 81 to 90 of about 971,800 (197)

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

Case Report: Familial hCG syndrome with elevated hCG level concurrently in blood and cerebrospinal fluid

Frontiers in Endocrinology
ObjectiveTo describe a rare pediatric case of familial human chorionic gonadotropin (hCG) syndrome presenting with concurrent elevation of beta-hCG (β-hCG) in both blood and cerebrospinal fluid (CSF). This report aims to expand the phenotypic spectrum of
Danyi Wang, Mengtian Huang, Mengtian Huang, Jun Zhang, Rujiang Zheng, Qiuli Chen, Song Guo, Bing Wang, Yanhong Li, Huamei Ma   +9 more
doaj   +1 more source

Effects of a lytic peptide conjugated to β hCG on ovarian cancer: Studies in vitro and in vivo

, 2002
Objective. The aim of this study was to determine the in vitro and in vivo effects of the lytic peptide, hecate, alone and conjugated to a 15-amino-acid fragment of the β-chain of hCG (hecate-β hCG) on the ovarian carcinoma cell line NIH: OVCAR-3 and ...
Enright, Frederick M., Gawronska, Barbara, Leuschner, Carola, Hansel, William   +3 more
core   +1 more source

Parallel Liquid Biopsy Analysis of miR‐371a‐3p and Cell‐Free DNA in an Unselected Cohort of Patients With Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background Despite robust data showing strong potential to improve diagnosis and disease monitoring in testicular germ cell tumors (TGCTs), miR‐371a‐3p testing has not yet been implemented in routine clinical practice. Cell‐free DNA (cfDNA) represents another promising liquid biopsy biomarker that may provide complementary molecular ...
Laura Matouskova, Romy Kralova, Eva Parobkova, Violeta Bakardjieva‐Mihaylova, Martina Zwyrtkova, Karolina Skvarova Kramarzova, Ludmila Boublikova   +6 more
wiley   +1 more source

Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy

BMC Pregnancy and Childbirth, 2020
Background Ectopic pregnancy is a major life- and fertility-threatening women’s health concern. As a result of advances in examination technology, an increasing number of ectopic pregnancies can be diagnosed early and treated with medical methods instead
Jing Zhang, Yu Zhang, Lu Gan, Xiao-ying Liu, Shan-ping Du   +4 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Study of clinical significance and histopathological correlation of serum β- hCG level [PDF]

, 2017
Background: β-hCG is a marker useful in diagnosis of gestational trophoblastic disease (GTD), ectopic gestation (EG), spontaneous abortion (SA) and malignant germ cell tumors (MGCT) and it is helpful to clinician as an excellent tumor marker.
Faruq Ibrahimbhai Mulla, Inaniya, Kailash Sukhram, Mulla, Faruq Ibrahimbhai, Kailash Sukhram Inaniya   +3 more
core   +1 more source

Higher LSD1 in Non‐Seminomatous Germ Cell Tumors and LSD1 Inhibition by NCL1 Suppresses Embryonal Carcinoma Growth

Cancer Science, EarlyView.
LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu, Toshiki Etani, Taku Naiki, Aya Naiki‐Ito, Yosuke Sugiyama, Takashi Nagai, Akihiro Murakami, Hiroyuki Kato, Toshiharu Morikawa, Maria Aoki, Masakazu Gonda, Hiroko Suzuki, Yohei Tsubouchi, Daiki Ishikawa, Takayoshi Suzuki, Satoru Takahashi, Takahiro Yasui   +16 more
wiley   +1 more source

False-negative urine human chorionic gonadotropin in molar pregnancy: " The high-dose hook effect" !

Journal of the Scientific Society, 2015
Failure to detect pregnancy in the emergency situations can have important consequences. These include missing of ectopic pregnancy (the leading cause of first-trimester pregnancy-related maternal death), administration of medications contraindicated in ...
Sujata Narendra Datti, Payel Ray, Jayashree Ashok Kumar Dharmavijaya   +2 more
doaj   +1 more source