Results 181 to 190 of about 56,729 (249)

Chemical Optimization of Temporin A–L Peptides: From Native Isoforms to Enhanced Antimicrobial Analogs

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Temporins, among antimicrobial peptides, are short frog‐derived molecules with potent antibacterial activity. This review highlights chemical optimization strategies applied to temporins A–L, showing how sequence tuning modulates structure, stability, and selectivity, enabling improved activity against resistant pathogens.
Ida Boccino   +2 more
wiley   +1 more source

Visible‐Light Photoredox Catalysis in the Intramolecular Dicarbonylation of Alkenes: Catalyst‐Dependent Divergent Syntheses of Both 1,4‐Dicarbonyls and α‐Hydroxy‐β,γ‐Unsaturated Lactams From 1,2‐Dicarbonyls

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
Catalyst‐dependent divergent syntheses were developed. Intramolecular dicarbonylation of vinyl halides under metal‐free either thermal or visible light photocatalytic conditions were explored to produce a series of 1,4‐dicarbonyls with two different carbonyl moieties and a lactam ring.
Chia‐Lin Li, Che‐Chien Chang
wiley   +1 more source

Chemoenzymatic Synthesis of Chiral Piperidines Using the Immobilized Transaminase ATA‐117 in Continuous Flow Reactors

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
A robust continuous flow chemoenzymatic process was developed for the stereoselective synthesis of cis‐(2R,6R)‐2,6‐disubstituted piperidines, including the natural alkaloid (–)‐pinidinone. The asymmetric transamination of α,β‐unsaturated ketones was catalyzed by immobilized ATA‐117, followed by spontaneous aza‐Michael cyclization, providing the desired
Sara Vicinanza   +11 more
wiley   +1 more source

The Development and Validation of a Simple Method for the Determination of Meropenem Concentrations in Human Plasma Using High‐Performance Liquid Chromatography

open access: yesApplied Research, Volume 5, Issue 4, August 2026.
A simple, rapid, and sustainable HPLC‐UV method was developed and validated to quantify meropenem in human plasma across a wide linear range (0.5–100 mg/L). Utilizing an efficient one‐step protein precipitation, this eco‐friendly approach is highly suited for routine clinical therapeutic drug monitoring and research purposes.
Asma Aboelezz   +2 more
wiley   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

open access: yesAnimal Research and One Health, Volume 4, Issue 3, Page 278-292, August 2026.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou   +4 more
wiley   +1 more source

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