Results 191 to 200 of about 937,622 (274)

Quantifying outer membrane permeability to β-lactam antibiotics using outer membrane vesicles that protect antibiotic-susceptible bacteria. [PDF]

Nat Commun
Razew A, Herail Q, Ayala I, Guissouma M, Arthur M, Simorre JP.   +5 more
europepmc   +1 more source

Novel Penicillin-Based Sulfone-Siderophore Conjugates for Restoring β‑Lactam Antibiotic Efficacy

ACS Omega
Diana Rodríguez, Emilio Lence, Juan C. Vázquez-Ucha, Alejandro Beceiro, Concepción González-Bello   +4 more
doaj   +1 more source

Polymersome‐Enabled Multimodal Delivery of Tobramycin and Doripenem for Targeted Eradication of Pseudomonas aeruginosa Biofilms in Chronic Rhinosinusitis

Small, EarlyView.
Schematic representation of diffusion‐based versus pH‐triggered drug release within a bacterial biofilm. In diffusion‐based systems, drug cargo is gradually released independent of local pH, resulting in rapid burst release and reduced sustained concentrations.
Amalie Kjær Andresen, Matteo Tollemeto, Alexander B. Cook, Claus Sternberg, Yudong Li, Claus Moser, Lars Jelsbak, Jan C. M. Van Hest, Anja Boisen, Line Hagner Nielsen   +9 more
wiley   +1 more source

Comparative evaluation of the activity of novel β-lactam antibiotics against difficult-to-treat <i>Pseudomonas aeruginosa</i> clinical isolates. [PDF]

JAC Antimicrob Resist
Mystakelis H, Shields RK, Mathers AJ, Bergman Y, Munita JM, Cosgrove SE, Simner PJ, Tamma PD.   +7 more
europepmc   +1 more source

Photo‐Switched Catalytic Amyloids

Small, EarlyView.
Photo‐switched reversible hierarchical assembly of catalytic amyloid fibrils is accomplished by mixing an amphiphilic cross‐ß peptide with a merocyanine photo switch. The peptide monomers, comprising phenylalanine‐lysine repeats, do not self‐assemble in water because of the electrostatic repulsion.
Shubhra Kanti Bhaumik, Sisira Mambram Kunnath, Elad Arad, Einat Nativ‐Roth, Arunavo Chatterjee, Albert Batushansky, Nitzan Shauloff, Hanna Rapaport, Raz Jelinek   +8 more
wiley   +1 more source

Extended lag phases and variable antibiotic tolerance in β-lactam-induced small colony variants of Enterococcus faecalis. [PDF]

BMC Microbiol
Thieme L, Mirza KA, Azimi M, Enslinger N, Lohde M, Jundzill M, Brandt C, Pletz MW, Makarewicz O.   +8 more
europepmc   +1 more source

Programmable 3D Microfluidics Reveals Motility‐Driven Antibiotic Resistance Evolution in Gradients

Small, EarlyView.
Using a programmable microfluidic platform, this study shows that bacterial motility is crucial for resistance development in heterogeneous antibiotic landscapes. Motile Escherichia coli randomly migrates along antibiotic gradients, and sufficient movement is required for resistance to emerge.
Xiaobo Li, Jianan Yin, Yanqing Song, Andrew Glidle, William Sloan, He Huang, Maggie Cusack, Cindy J. Smith, Huabing Yin   +8 more
wiley   +1 more source

Structural Interactions of β-Lactam Antibiotics with Mammalian Serum Albumins. [PDF]

Int J Mol Sci
Duszynski K, Sekula B, Talaj J, Bujacz A.   +3 more
europepmc   +1 more source

Filtration‐Based SERS With In Situ Gold Growth in Bacterial Microenvironment for Rapid Detection of Low‐Level Bacteria

Small Methods, EarlyView.
A filtration‐assisted SERS platform integrating in situ gold growth within the bacterial microenvironment enables rapid and highly sensitive detection of low‐level bacteria in complex biological matrices. By overcoming hotspot–bacteria mismatch, the platform simultaneously achieves selective bacterial identification and rapid antimicrobial ...
Eun‐Bi Jang, Ji Young Lee, Hoeil Chung, Min‐Young Lee   +3 more
wiley   +1 more source

A mini review of genome-predicted β-lactam susceptibility in <i>Streptococcus pneumoniae</i>: from PBP profiles to potential clinical interpretation. [PDF]

Front Cell Infect Microbiol
Yan Z, Liu L, Ren Y, Ling J, Liao J, Liu X, Li Y, Wang X, Kuang L, Zhou W, Jiang Y, Cui Y.   +11 more
europepmc   +1 more source