Results 71 to 80 of about 764,478 (294)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Combatting Pseudomonas aeruginosa with β-Lactam Antibiotics: A Revived Weapon?

Antibiotics
Pseudomonas aeruginosa is a significant threat to public health as an aggressive, opportunistic pathogen. The use of β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems remains a front-line treatment against P ...
Dylan W. Zhao, Christopher T. Lohans
doaj   +1 more source

Total Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from Mycale sp. Employing a β-Lactam-Based Macrocyclization

, 2016
Total Synthesis of the Novel, Immunosuppressive Agent (−)-Pateamine A from Mycale sp.
Daniel Romo (246583), Robert M. Rzasa (1692925), Helene A. Shea (2705461)   +2 more
core   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

A novel method to depurate β-lactam antibiotic residues by administration of a broad-spectrum β-lactamase enzyme in fish tissues

Fisheries and Aquatic Sciences, 2016
As a novel strategy to remove β-lactam antibiotic residues from fish tissues, utilization of β-lactamase, enzyme that normally degrades β-lactam structure-containing drugs, was explored.
Young-Sik Choe, Ji-Hoon Lee, Soo-Geun Jo, Kwan Ha Park   +3 more
doaj   +1 more source

Teicoplanin versus β-lactam for febrile patients with Staphylococcus-like bacteremia: focus on methicillin-susceptible Staphylococcus aureus bacteremia

BMC Infectious Diseases, 2021
Background Many studies have shown that vancomycin is inferior to β-lactam antibiotics in terms of effectiveness in the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia.
Ching-Yen Tsai, Chen-Hsiang Lee, I-Ling Chen   +2 more
doaj   +1 more source

Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics

Antibiotics, 2023
Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water ...
Sarmistha Biswal, Karina Caetano, Diamond Jain, Anusha Sarrila, Tulika Munshi, Rachael Dickman, Alethea B. Tabor, Surya Narayan Rath, Sanjib Bhakta, Anindya S. Ghosh   +9 more
doaj   +1 more source

Novel β-lactam-β-lactamase inhibitor combinations: expectations for the treatment of carbapenem-resistant Gram-negative pathogens

, 2019
Introduction: The burden of antimicrobial resistance among Gram-negative bacteria is increasing and growing into a major threat of public health. Treatment options for carbapenem-resistant Enterobacteriaceae are limited and resistance rates to existing ...
Irene Galani (6193556), Helen Giamarellou (65000), Ilias Karaiskos (4370434), Maria Souli (3828589)   +3 more
core   +1 more source

Trimeric Tobramycin/Nebramine Synergizes β‑Lactam Antibiotics against Pseudomonas aeruginosa

, 2023
β-Lactam antibiotics remain one of the most effective therapeutics to treat infections caused by Gram-negative bacteria (GNB). However, since ancient times, bacteria have developed multiple resistance mechanisms toward this class of antibiotics including
Shiv Dhiman, Gilbert Arthur (2274238), Ayush Kumar (199516), Danyel Ramirez (8812073), Rajat Arora, Ruwani Wimalasekara (16726167), Frank Schweizer (148473), Rajat Arora (16726161), Ayush Kumar, Frank Schweizer, Karan Gandhi, Shiv Dhiman (1763281), Karan Gandhi (16726164), Danyel Ramirez, Gilbert Arthur, Ruwani Wimalasekara   +15 more
core   +1 more source