Results 251 to 260 of about 1,666,677 (276)

Synthesis of Exclusively 4-Substituted β-Lactams through the Kinugasa Reaction Utilizing Calcium Carbide.

Organic Letters, 2019
A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted β-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF·3H2O in the presence of CuCl/NMI.
A. Hosseini, P. Schreiner
semanticscholar   +1 more source

Early therapeutic monitoring of β-lactams and associated therapy outcomes in critically ill patients.

Journal of Antimicrobial Chemotherapy, 2020
BACKGROUND In the ICU, early and appropriate antimicrobial therapy is important to lower infection-related mortality. OBJECTIVES Assess whether achieving early β-lactam free concentration above the MIC 100% of the time (fT>MIC) is associated with ...
M. Al-Shaer, Eric Rubido, K. Cherabuddi, V. Venugopalan, K. Klinker, C. Peloquin   +5 more
semanticscholar   +1 more source

Diazoketones as precursors in β-lactam synthesis. New insights into the mechanism of the photochemically induced Staudinger reaction

Journal of the Chemical Society, Perkin Transactions 1, 2001
Diazoketones 1–3, derived from suitably protected amino acids (Ala, Val and Tle), have been photochemically rearranged in the presence of imines leading exclusively to trans-arranged 4-aryl- and cinnamoyl-substituted β-lactams 17–33 with up to 84% yield. Selectivities were dependent on the steric demand of the amino acid side-chain ranging from 65 ∶ 35
Michael R. Linder, Wolfgang U. Frey, Joachim Podlech   +2 more
openaire   +1 more source

Synthesis of 4-aminoguaiazulene and its δ-lactam derivatives

Tetrahedron Letters, 2011
Abstract A method for nitrogen insertion into guaiazulene hydrocarbons is developed. A one-pot reaction of 7-isopropyl-1-methylazulene-4-carboxylic acid, diphenylphosphoryl azide, and an alcohol (MeOH, tBuOH or BnOH) affords the corresponding carbamates.
Kiriazis Alexandros, Aumuller Ingo, Yli-Kauhaluoma Jari   +2 more
openaire   +1 more source

Synthesis of spiro-annelated γ-lactams by isocyanide-based multicomponent reactions involving hem-disubstituted bifunctional reagents

Proceedings of The 17th International Electronic Conference on Synthetic Organic Chemistry, 2013
The new bifunctional hem-disubstituted alicyclic compounds IIIa-e and IVa-e were synthesized in several steps involving alkylation with allyl bromide following oxidative cleavage. Hem-disubstitues oxo-esters IIIa-e were introduced into azido-Ugi reaction followed by one-pot intramolucular bond formation to afford 3-(tetrazol-5-yl)-2-azaspiro[4.n]alkan ...
Vasiliy Stolyarenko, Ananatoliy Evdokimov, Vladimir Shishkin   +2 more
openaire   +1 more source

Bacterial production of carbapenems and clavams: evolution of β-lactam antibiotic pathways

Trends in Microbiology, 1998
Research into two of the four classes of naturally produced beta-lactams--the clavams and carbapenems--has started to throw light upon their biochemical pathways and underlying genetics. Interesting similarities between these two classes, from their joint discovery to an apparently common beta-lactam ring-forming enzyme, are now being revealed.
S J, McGowan, B W, Bycroft, G P, Salmond
openaire   +2 more sources

Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials.

Lancet. Infectious Diseases (Print), 2018
K. Vardakas, Georgios L. Voulgaris, A. Maliaros, G. Samonis, M. Falagas   +4 more
semanticscholar   +1 more source

Synthesis and evaluation of biological activities of tripodal imines and β-lactams attached to the 1,3,5-triazine nucleus

Chemical Monthly, 2020
Mohammad Ali Bashiri, A. Jarrahpour, Banafsheh Rastegari, Aida Iraji, C. Irajie, Z. Amirghofran, Saeed Malek-hosseini, M. Motamedifar, Mahtab Haddadi, K. Zomorodian, Z. Zareshahrabadi, E. Turos   +11 more
semanticscholar   +1 more source

Clinical Evaluation of In Vitro Tests in Diagnosis of Immediate Allergic Reactions to β-Lactam Antibiotics

Allergy & Clinical Immunology International - Journal of the World Allergy Organization, 2002
María Sanz, P.M. Gamboa, A.L. de Weck
openaire   +1 more source

Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of β-lactams administered by continuous infusion: a prospective observational study.

International Journal of Antimicrobial Agents, 2017
C. Carrié, L. Petit, N. d'Houdain, N. Sauvage, V. Cottenceau, Mélanie Lafitte, C. Foumenteze, Quentin Hisz, Deborah Menu, Rachel Legeron, D. Breilh, F. Sztark   +11 more
semanticscholar   +1 more source