Results 1 to 10 of about 14,889 (112)

A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway [PDF]

Acta Biochimica et Biophysica Sinica, 2023
Glioma is characterized by rapid cell proliferation, aggressive invasion, altered apoptosis and a poor prognosis. β-Sitosterol, a kind of phytosterol, has been shown to possess anticancer activities. Our current study aims to investigate the effects of β-
Xie Yufang, Chen Zhijian, Li Shuang, Yan Meijuan, He Wenjun, Li Li, Si Junqiang, Wang Yan, Li Xinzhi, Ma Ketao   +9 more
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Therapeutic potential of β-sitosterol in methotrexate-induced liver injury: association with STING and ERK-1 pathways [PDF]

BMC Gastroenterology
Background Methotrexate (MTX) is a commonly used drug to treat various cancers and autoimmune disorders, but its clinical utility is often limited by hepatotoxicity.
Mehmet Ulusan, Mustafa Yildiz, Mumin Alper Erdogan, Ozkan Simsek, Bertug Bekir Ciftci, Mesih Kocamuftuoglu, Oytun Erbas   +6 more
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β-sitosterol improves the pathological progression of PCOS by targeting ESR1 to inhibit autophagy activity [PDF]

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women, mainly marked by elevated levels of androgens, irregular ovulation, and the presence of multiple cysts in the ovaries.
Mengting Chen, Jingwen Meng, Yuan Liu, Yafang Jin, Xiong Yuan, Zhiquan Qin, Yang Zhou   +6 more
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β-sitosterol suppresses malignant biological behaviors and glycolysis via modulating YBX1-hnRNP K interaction in non-small cell lung cancer [PDF]

Scientific Reports
Non-small cell lung cancer (NSCLC) is the most prevalent form of lung malignancy. As a type of phytosterol, β-sitosterol shares structural similarities with cholesterol and has been shown to possess multiple pharmacological properties.
Guolu Ma, Jianyu Feng, Jianying Zeng, Rongxin Liao, Xiaojun Zhong, Zhuo Lv, Fengsheng Chen   +6 more
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β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE-/- mice. [PDF]

PLoS ONE
BackgroundAtherosclerosis (AS), driven by chronic inflammation and oxidative stress, remains a leading cause of cardiovascular morbidity. While β-sitosterol, a dietary phytosterol, shows therapeutic potential for AS, its mechanisms remain unclear.
Weiping Wu, Wugao Liu, Ningjun Wu, Chunsheng Qu, Weihua Chu, Jing Jin   +5 more
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Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis [PDF]

Neural Regeneration Research
[INLINE:1] β-Sitosterol is a type of phytosterol that occurs naturally in plants. Previous studies have shown that it has anti-oxidant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, and anti-tumor effects, but it is unknown whether β ...
Xiuling Tang, Tao Yan, Saiying Wang, Qingqing Liu, Qi Yang, Yongqiang Zhang, Yujiao Li, Yumei Wu, Shuibing Liu, Yulong Ma, Le Yang   +10 more
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β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis [PDF]

Stem Cell Research & Therapy
Background Osteoarthritis (OA) is a joint disorder that severely affects patients’ mobility, overall health, and ability to perform daily activities. Despite advancements in therapeutic strategies, stem cell-based therapies for OA still face challenges ...
Chengyin Liu, Xiaoman Wang, Yanyan Zhang, Hongfan Ge, Qi Chang, Zhenlei Zhou   +5 more
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β-Sitosterol attenuates obstructive sleep apnea-related myocardial injury via MALAT1-mediated HIF-1α regulation [PDF]

Frontiers in Pharmacology
BackgroundObstructive sleep apnea (OSA) is associated with chronic intermittent hypoxia (CIH), which contributes to myocardial injury. Although continuous positive airway pressure (CPAP) is the standard therapy, patient compliance remains challenging.
Runhua Wu, Naijie Chen, Jingyi Li, Dan Liu, Feng Wang, Qin Chen   +5 more
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β-sitosterol alleviates atherosclerosis by regulating catalase

Heliyon
The aim of this study is to investigate the main active components of Gegen (Puerariae Lobatae Radix) on atherosclerosis and its mechanism of action. Bioinformatics analysis showed that β-sitosterol was the most likely active ingredient to mediate the ...
Shuntao Jiang, Kui Gao, Furong Zhang, Yanli Wang, Xiaojing He, Jun Yang   +5 more
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β-Sitosterol Inhibits The Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway [PDF]

Cell Journal, 2023
Objective: To investigate the effect of β-sitosterol on endometrial cells to understand the underlying mechanism.Materials and Methods: This is a laboratory-based experimental study conducted on animals and cells.
Yi Wen, Lili Pang, Lingxiu Fan, Yihan Zhou, Ruonan Li, Tingting Zhao, Manli Zhang   +6 more
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