A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway [PDF]
Acta Biochimica et Biophysica Sinica, 2023 Glioma is characterized by rapid cell proliferation, aggressive invasion, altered apoptosis and a poor prognosis. β-Sitosterol, a kind of phytosterol, has been shown to possess anticancer activities. Our current study aims to investigate the effects of β-
Xie Yufang +9 more
doaj +2 more sources
Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an
BMC Complementary and Alternative Medicine, 2010 Background Asclepias curassavica Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours.
Paulraj Gabriel M +3 more
doaj +3 more sources
Therapeutic potential of β-sitosterol in methotrexate-induced liver injury: association with STING and ERK-1 pathways [PDF]
BMC GastroenterologyBackground Methotrexate (MTX) is a commonly used drug to treat various cancers and autoimmune disorders, but its clinical utility is often limited by hepatotoxicity.
Mehmet Ulusan +6 more
doaj +2 more sources
β-sitosterol improves the pathological progression of PCOS by targeting ESR1 to inhibit autophagy activity [PDF]
Journal of Ovarian ResearchBackground Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women, mainly marked by elevated levels of androgens, irregular ovulation, and the presence of multiple cysts in the ovaries.
Mengting Chen +6 more
doaj +2 more sources
β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE-/- mice. [PDF]
PLoS ONEBackgroundAtherosclerosis (AS), driven by chronic inflammation and oxidative stress, remains a leading cause of cardiovascular morbidity. While β-sitosterol, a dietary phytosterol, shows therapeutic potential for AS, its mechanisms remain unclear.
Weiping Wu +5 more
doaj +2 more sources
Marine Drugs, 2016 The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice.
Donghai Zhao +6 more
doaj +3 more sources
β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis [PDF]
Stem Cell Research & TherapyBackground Osteoarthritis (OA) is a joint disorder that severely affects patients’ mobility, overall health, and ability to perform daily activities. Despite advancements in therapeutic strategies, stem cell-based therapies for OA still face challenges ...
Chengyin Liu +5 more
doaj +2 more sources
Treatment with β-sitosterol ameliorates the effects of cerebral ischemia/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis [PDF]
Neural Regeneration Research[INLINE:1] β-Sitosterol is a type of phytosterol that occurs naturally in plants. Previous studies have shown that it has anti-oxidant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, and anti-tumor effects, but it is unknown whether β ...
Xiuling Tang +10 more
doaj +2 more sources
β-Sitosterol attenuates obstructive sleep apnea-related myocardial injury via MALAT1-mediated HIF-1α regulation [PDF]
Frontiers in PharmacologyBackgroundObstructive sleep apnea (OSA) is associated with chronic intermittent hypoxia (CIH), which contributes to myocardial injury. Although continuous positive airway pressure (CPAP) is the standard therapy, patient compliance remains challenging.
Runhua Wu +5 more
doaj +2 more sources
β-Sitosterol Reduces the Content of Triglyceride and Cholesterol in a High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Zebrafish (Danio rerio) Model [PDF]
AnimalsObjective: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with hyperlipidemia, which is closely related to high levels of sugar and fat.
Peng Zhang +9 more
doaj +2 more sources