Marine Drugs, 2016 The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice.
Donghai Zhao +2 more
exaly +4 more sources
β-sitosterol alleviates atherosclerosis by regulating catalase.
HeliyonThe aim of this study is to investigate the main active components of Gegen (Puerariae Lobatae Radix) on atherosclerosis and its mechanism of action. Bioinformatics analysis showed that β-sitosterol was the most likely active ingredient to mediate the ...
Jiang S +5 more
europepmc +3 more sources
β-sitosterol alleviated HFD-induced atherosclerosis by regulating the MAPK/Nrf2/NLRP3 pathway in ApoE-/- mice. [PDF]
PLoS OneBackgroundAtherosclerosis (AS), driven by chronic inflammation and oxidative stress, remains a leading cause of cardiovascular morbidity. While β-sitosterol, a dietary phytosterol, shows therapeutic potential for AS, its mechanisms remain unclear.
Wu W, Liu W, Wu N, Qu C, Chu W, Jin J.
europepmc +3 more sources
<i>β-Sitosterol</i> attenuates obstructive sleep apnea-related myocardial injury via MALAT1-mediated HIF-1α regulation. [PDF]
Front PharmacolBackgroundObstructive sleep apnea (OSA) is associated with chronic intermittent hypoxia (CIH), which contributes to myocardial injury. Although continuous positive airway pressure (CPAP) is the standard therapy, patient compliance remains challenging.
Wu R +5 more
europepmc +4 more sources
β-Sitosterol preconditioning enhances the resistance of BMSCs and chondrocyte to oxidative stress and promotes cartilage repair in osteoarthritis. [PDF]
Stem Cell Res TherBackground Osteoarthritis (OA) is a joint disorder that severely affects patients’ mobility, overall health, and ability to perform daily activities. Despite advancements in therapeutic strategies, stem cell-based therapies for OA still face challenges ...
Liu C +5 more
europepmc +3 more sources
A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway. [PDF]
Acta Biochim Biophys Sin (Shanghai), 2023 Glioma is characterized by rapid cell proliferation, aggressive invasion, altered apoptosis and a poor prognosis. β-Sitosterol, a kind of phytosterol, has been shown to possess anticancer activities. Our current study aims to investigate the effects of β-
Xie Y +9 more
europepmc +2 more sources
Therapeutic potential of β-sitosterol in methotrexate-induced liver injury: association with STING and ERK-1 pathways. [PDF]
BMC GastroenterolBackground Methotrexate (MTX) is a commonly used drug to treat various cancers and autoimmune disorders, but its clinical utility is often limited by hepatotoxicity.
Ulusan M +6 more
europepmc +2 more sources
β-sitosterol improves the pathological progression of PCOS by targeting ESR1 to inhibit autophagy activity. [PDF]
J Ovarian ResBackground Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder among women, mainly marked by elevated levels of androgens, irregular ovulation, and the presence of multiple cysts in the ovaries.
Chen M +6 more
europepmc +2 more sources
β-sitosterol suppresses malignant biological behaviors and glycolysis via modulating YBX1-hnRNP K interaction in non-small cell lung cancer. [PDF]
Sci RepNon-small cell lung cancer (NSCLC) is the most prevalent form of lung malignancy. As a type of phytosterol, β-sitosterol shares structural similarities with cholesterol and has been shown to possess multiple pharmacological properties.
Ma G +6 more
europepmc +2 more sources
β-Sitosterol Inhibits The Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway [PDF]
Cell Journal, 2023 Objective: To investigate the effect of β-sitosterol on endometrial cells to understand the underlying mechanism.Materials and Methods: This is a laboratory-based experimental study conducted on animals and cells.
Yi Wen +6 more
doaj +1 more source