Results 11 to 20 of about 872,130 (197)

Psychological morbidity among children with transfusion dependent β-thalassaemia and their parents in Sri Lanka. [PDF]

PLoS ONE, 2020
BACKGROUND:Thalassaemia is a chronic disease which requires lifelong treatment in a majority. Despite recent advances in the medical care, minimal attempts are made to improve psychological health in these patients.
Sachith Mettananda, Ravindu Peiris, Hashan Pathiraja, Miyuru Chandradasa, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena   +7 more
doaj   +3 more sources

The disease burden of β-thalassaemia revisited

Hematology
Objective The complexity of β-thalassaemia with associated morbidity, lifelong daily expensive treatment, and multidisciplinary care results in a considerable disease burden.
Elpidoforos S. Soteriades, Michael Angastiniotis, Eleftheria C. Economidou, Dimitrios Farmakis, Demetris Avraam, Androulla Eleftheriou   +5 more
doaj   +2 more sources

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice [PDF]

Scientific Reports
Iron overload has been associated with cerebrovascular disease and cognitive impairment in β-thalassaemia patients, typically appearing earlier than in the general population.
Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo   +7 more
doaj   +2 more sources

Microparticles from β-thalassaemia/HbE patients induce endothelial cell dysfunction

Scientific Reports, 2018
Thromboembolic complication occurs frequently in β-thalassaemia/HbE patients, particularly in splenectomised patients. Endothelial cells play an important role in thrombosis.
Wasinee Kheansaard, Kunwadee Phongpao, Kittiphong Paiboonsukwong, Kovit Pattanapanyasat, Pornthip Chaichompoo, Saovaros Svasti   +5 more
doaj   +2 more sources

Clinical validation of a single-tube PCR and reverse dot blot assay for detection of common α-thalassaemia and β-thalassaemia in Chinese [PDF]

Journal of International Medical Research, 2022
Objective To evaluate a novel reverse dot blot assay for the simultaneous detection six types of common α-thalassaemia alleles (three deletional and three common non-deletional mutations) and 19 types of common β-thalassaemia alleles in a Chinese ...
Hong-Feng Liang, Lie-Jun Li, Hui Yang, Xiang-Bin Zheng, Min Lu, Yi-Yuan Ge, Fen Lin, Long-Xu Xie, Li-Ye Yang   +8 more
doaj   +2 more sources

A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia [PDF]

Scientific Reports, 2022
Hydroxyurea is an antimetabolite drug that induces fetal haemoglobin in sickle cell disease. However, its clinical usefulness in β-thalassaemia is unproven.
Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda   +11 more
doaj   +2 more sources

Prenatal Diagnosis of β Thalassaemia Tazeen Anwar*,

Journal of Rawalpindi Medical College, 2014
Background: To study the effectiveness of choronic villous sampling, followed by molecular analysis, for prenatal diagnosis of β thalassaemia Methods: In this descriptive study 116 high risk mothers with 12-16 weeks of pregnancy, underwent choronic ...
Tazeen Anwar
doaj   +2 more sources

Advancing the care of β-thalassaemia patients with novel therapies. [PDF]

Blood Transfus, 2022
The β-thalassaemias are a group of inherited disorders of haemoglobin synthesis characterised by chronic anaemia of varying severity. Currently available conventional therapies in thalassaemia have many challenges and limitations.
Bou-Fakhredin R, Motta I, Cappellini MD.
europepmc   +2 more sources

Association of GDF15 levels with body mass index and endocrine status in β-thalassaemia. [PDF]

Clin Endocrinol (Oxf), 2023
OBJECTIVE: GDF15 has emerged as a stress-induced hormone, acting on the brain to reduce food intake and body weight while affecting neuroendocrine function. Very high GDF15 levels are found in thalassaemia, where growth, energy balance and neuroendocrine
Karusheva Y, Petry CJ, Yasara N, Kottahachchi D, Premawardhena A, Barker P, Burling K, Sattar N, Welsh P, Mettananda S, O'Rahilly S.   +10 more
europepmc   +5 more sources

β-Thalassaemia and its Co-existence with Haemoglobin E and Haemoglobin S in Upper Assam Region of North Eastern India: A Hospital Based Study [PDF]

Journal of Clinical and Diagnostic Research, 2016
Introduction: β-Thalassaemias are common genetic disorders in the Indian subcontinent and its status has not been well studied in the Upper Assam region of North Eastern India.
Anju Barhai Teli, Rumi Deori, Sidhartha Protim Saikia, Kalyani Pathak, Rita Panyang, Rashmi Rajkakati   +5 more
doaj   +1 more source