Results 81 to 90 of about 872,130 (197)

Effects of transfusion and splenectomy on globin chain expression in NTDT HbE/β-thalassaemia [PDF]

, 2021
Introduction: Majority of HbE/β-thalassaemia patients resembles the phenotype of non-transfusion dependent thalassaemia (NTDT). Current management strategies are highly diverse, and the objective of this study is to examine the effects of different ...
George, Elizabeth, Lai, Kuan Teh, Lai, Mei I., Lim, Wai Feng, Sathar, Jameela   +4 more
core   +2 more sources

Analysis of Haemoglobin Profile in Haemoglobinopathies by High Performance Liquid Chromatography and Capillary Zone Electrophoresis Methods: A Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Mutation or deletion of one of the globin genes of haemoglobin results in thalassaemias and haemoglobinopathies. Two diagnostic modalities that can be used to study haemoglobin abnormalities are High-Performance Liquid Chromatography (HPLC)
Pallavi Kommoju, Sruthi Nannapaneni, Sree Ramya Dangeti, Dharmatej Yarlagadda   +3 more
doaj   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

New challenges in diagnosis of haemoglobinopathies: Migration of populations

Thalassemia Reports, 2018
The current influx of economic migrants and asylum seekers from countries with a high prevalence of haemoglobinopathies creates new challenges for health care systems and diagnostic laboratories.
John Old, Adele Timbs, Janice McCarthy, Alice Gallienne, Melanie Proven, Michelle Rugless, Herminio Lopez, Jennifer Eglinton, Dariusz Dziedzic, Matthew Beardsall, Mohamed S.M. Khalila, Shirley Henderson   +11 more
doaj   +1 more source

Relationship between the severity of β-thalassaemia syndromes and the number of alleviating mutations

, 1997
Thalassaemia intermedia, defined as homozygous β-thalassaemia in which patients are not transfusion-dependent, covers a wide range of clinical severity.

core   +1 more source

Differentiating β‐Thalassaemia From Iron Deficiency: Performance and Cut‐Off Dependency of More Than 40 Red Cell Discrimination Indices in a Large German Cohort

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Since the 1970s, more than 40 red blood cell–based formulas have been proposed to differentiate β‐thalassaemia trait (BTT) from iron deficiency (ID) and iron deficiency anaemia (IDA), the main causes of microcytic anaemia. In Germany, where haemoglobinopathies are rare in the autochthonous population but increasingly encountered due
Rafid Al‐Nabhan, Dani Hakimeh, Lena Oevermann   +2 more
wiley   +1 more source

Body iron status of children and adolescents with transfusion dependent β-thalassaemia: trends of serum ferritin and associations of optimal body iron control

BMC Research Notes, 2018
Objective This cross sectional study aims to describe the body iron status, trends of serum ferritin and associations of optimal body iron control in patients aged below 16 years with transfusion dependent β-thalassaemia attending Paediatric and ...
Tharindi Suriapperuma, Ravindu Peiris, Chamila Mettananda, Anuja Premawardhena, Sachith Mettananda   +4 more
doaj   +1 more source

A retrospective analysis of the antigen‐negative red blood cell supply conducted at a single centre in China

Transfusion Medicine, EarlyView.
Abstract Objective This study aimed to analyse the distribution and demand patterns of antigen‐negative red blood cells (RBCs) in Shandong Province, China (2022–2024), with a focus on ABO blood groups and clinically significant antigens. The research was designed to provide rigorous data for advancing precision transfusion protocols and to establish a ...
Aiping Zhao, Xiujiao Jiang, Li An, Yuanfeng Chen, Weidong He, Qun Xu, Wenchao Li, Yingfang Pan   +7 more
wiley   +1 more source

BamH I polymorphism in the Chinese: Its potential usefulness in prenatal diagnosis of β thalassaemia

, 1984
The prevalence of the BamH I site 3' to the β globin gene in Chinese people was determined in 123 normal subjects, 40 patients with heterozygous β thalassaemia, and 25 patients with homozygous β thalassaemia.
Chan, TK, Chan, V, Leung, NK
core   +1 more source

A global survey of blood transfusion practices for patients with sickle cell disease

Transfusion, EarlyView.
Abstract Background Sickle cell disease (SCD) affects over 7 million people globally, with blood transfusion remaining a cornerstone of management. However, contemporary transfusion practices across diverse settings remain poorly characterized. We evaluated global transfusion practices for patients with SCD to identify gaps and inform resource ...
Jeremy W. Jacobs, Arwa Z. Al‐Riyami, Jeannie Callum, Meghan Delaney, David Daniel, Jenny White, Christopher Bocquet, Mohammed Farouk, Claude Tayou, Chinelo P. Onyenekwu, Kristina Prus, Divjot Singh Lamba, Julie Makani, Quentin Eichbaum, Luiz Amorim, Silvano Wendel, France Pirenne, Vernon Louw, Evan M. Bloch   +18 more
wiley   +1 more source