Results 91 to 100 of about 22,283 (171)

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

Chemistry – A European Journal, Volume 32, Issue 30, 13 August 2026.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez, Sylvain Kumanski, Zeineb Ayed, Aurélie Fournet, Charlène Bouanchaud, Amin Sagar, Frédéric Allemand, Vladimir A. Baulin, Ute Resch‐Genger, Juan Cortés, Nathalie Sibille, Fabien Chirot, Karl David Wegner, Rodolphe Antoine, Xavier Le Guével, Pau Bernadó   +15 more
wiley   +1 more source

The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research

The Anatomical Record, Volume 309, Issue 8, Page 2151-2175, August 2026.
Abstract Scientists have been captivated by the ability to regenerate, focusing on uncovering the mechanisms of epimorphic regeneration and applying them to human medicine. The axolotl (Ambystoma mexicanum) has become the most intensively studied model in tetrapod regeneration research, particularly concerning limb regeneration.
Vivien Bothe, Nadia Fröbisch
wiley   +1 more source

Targeting Elastin‐Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease

MedComm, Volume 7, Issue 8, August 2026.
In COPD, extracellular matrix and elastin degradation increase elastin‐derived peptides (EDPs), which are associated with TLR4/NF‐κB activation, DKK1 upregulation, reduced β‐catenin signaling, and impaired AT2‐to‐AT1 differentiation. Neutralization of EDPs by TB partially restores β‐catenin‐associated alveolar epithelial differentiation and attenuates ...
Huijuan Zhu, Yiling Zhao, Yingchao Qin, Wenfeng Huang, Jiarui Weng, Zihan Liu, Jiahong Kuang, Zibei Feng, Zhilian Ye, Peiji Zheng, Xiaolan Guo, Fei Cui, Bingjie Chen, Pixin Ran, Jianwei Dai   +14 more
wiley   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
The disruption of proteostasis, encompassing the ubiquitin–proteasome system, autophagy, UPR/ER stress, and chaperone function, represents a fundamental mechanism shared by both cancer and cardiovascular diseases. While these pathways frequently facilitate tumor progression, they are crucial for maintaining proteostasis in cardiac tissue. Consequently,
Jacob Eli García Torres, Norbert Frey, Ashraf Yusuf Rangrez   +2 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Physiological Basis of Sex Differences in Human Performance and Exercise‐Associated Pathology

Clinical Endocrinology, Volume 105, Issue 2, Page 151-162, August 2026.
ABSTRACT The presence of sex differences in human physical performance is well‐established and shaped by distinct endocrine, anatomical and physiological mechanisms. Despite sustained advances, our understanding of how inherent biological factors drive variations in exercise capacity and related pathologies is still developing.
David A. Holdsworth, Thomas J. O'Leary, Craig L. Doig, Natalie Taylor, Jasminder Dosanjh, David R. Woods, Michael J. Stacey, Robert M. Gifford   +7 more
wiley   +1 more source

β3‐AR/β‐arrestin2 Interaction Triggers Cardiac Fibrosis Through JNK/c‐Jun Pathway in Cardiac Fibroblasts

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Myocardial fibrosis (MF) is a critical pathological substrate of heart failure (HF), and β3‐adrenergic receptor (β3‐AR) has been implicated in cardiac remodelling with controversial roles. This study aimed to clarify the pro‐fibrotic mechanism of β3‐AR in cardiac fibroblasts and its association with β‐arrestin2‐mediated biased activation ...
Zhongcheng Xu, Min Zhu, Chun Zhou, Juncang Duan, Jian Ding, Jun Liu, Xuan Ying, Jie Wu, Yang Dong, Wenbiao Wang, Zhaohui Qiu   +10 more
wiley   +1 more source

Estradiol Replacement Modulates Synaptic Transmission‐Related Proteins in the Hippocampus of Ovariectomized Rats: An Exploratory Proteomic Approach

Journal of Neurochemistry, Volume 170, Issue 8, August 2026.
The estrogen deficiency in the hippocampus influences cognitive functions and control of food intake. Hippocampi of female rats, either control or ovariectomized, with or without estrogen replacement, were submitted to LC–MS/MS and analysis of pathway‐based functional roles of proteins affected by estrogen deficiency and replacement.
Amanda Paula Pedroso, Adriana Pereira Souza, Guilherme Araújo Câmara, Meira Maria Forcellini Machado, Valter Tadeu Boldarine, Lila Missae Oyama, Mônica Marques Telles, Alexandre Keiji Tashima, Eliane Beraldi Ribeiro   +8 more
wiley   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

Journal of Small Animal Practice, Volume 67, Issue 8, Page 663-679, August 2026.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon, L. Köster, E. Vettorato, A. H. Estrada   +3 more
wiley   +1 more source

Catecholamines Activate a Tumour Progression Program in Differentiated Tumour Hepatocytes

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims The sympathetic nervous system is involved in the progression and aggressiveness of several cancers, including hepatocellular carcinoma (HCC). However, the specific effects of sympathetic innervation and catecholamines on tumour hepatocyte behaviour remain poorly understood.
Elise Lelou, Claudine Rauch, Hélène Dubois‐Pot‐Schneider, Marjorie Dufresne, Abolfazl Zekri Yazdi, Maelle Guillout, Luis Cano, Lise Desquilles, Nicolas Nesseler, Marc Bourgeois, Claude Bendavid, Julie Massart, Orlando Musso, Anne Corlu, Caroline Aninat   +14 more
wiley   +1 more source