Results 61 to 70 of about 24,699 (164)
PLoS ONE, 2014 BackgroundA number of factors, including gender, age, smoking habits, and occupational exposure, affect the levels of urinary cadmium. Few studies have considered these influences when calculating the benchmark dose (BMD) of cadmium. In the present study,
Jia Hu +6 more
doaj +1 more source
To Treat or Not to Treat: Navigating Early‐Stage CLL in the Era of Targeted Therapy
European Journal of Haematology, EarlyView.ABSTRACT Chronic lymphocytic leukemia (CLL) is most frequently diagnosed at early, asymptomatic stages (Rai 0/Binet A), in which a watch‐and‐wait strategy remains the standard of care, based on historical trials demonstrating no overall survival benefit from early treatment.
Enrica Antonia Martino +16 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Multiple myeloma (MM) is an incurable malignancy of terminally‐differentiated plasma cells that represents a major clinical challenge despite unprecedented therapeutic advances, particularly for patients with cytogenetically‐defined high‐risk MM (HR‐MM).
Niamh McAuley +10 more
wiley +1 more source
Revista de Nefrología, Diálisis y Trasplante, 2014 Introduction: On line high volume hemodiafiltration (HVHDF) has shown to improve the clearance of medium molecules in dialyzed patients through high volumes of convection.
Carlos Najún Zarazaga +4 more
doaj
European Journal of Haematology, EarlyView.ABSTRACT Extranodal marginal zone lymphoma (EMZL) represents a unique paradigm among indolent B‐cell neoplasms, in which lymphomagenesis is frequently driven by chronic antigenic stimulation within tissue‐specific microenvironments. Persistent infectious or autoimmune triggers promote the development of ectopic lymphoid tissue and sustain B‐cell ...
Mamdouh Skafi +15 more
wiley +1 more source
Combating ageing beyond the cell: Emerging roles of extracellular proteostasis
The FEBS Journal, EarlyView.Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh +7 more
wiley +1 more source
PLASMA CYTOKINES LEVELS IN PATIENTS UNDERGOING LONG-TERM HAEMODIALYSIS
Медицинская иммунология, 2014 Аbstract. Patients with end-stage renal disease need their kidney functions to be replaced. Chronic haemodialysis represents a most common method of such substitution treatment.
D. S. Polyakov +5 more
doaj +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak +6 more
wiley +1 more source
Post‐Translational Isoaspartate Promotes Amyloid Formation in β2‐Microglobulin
Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.Chemical synthesis of five β2‐microglobulin (β2m) variants reveals the structural impact of Asn deamidation. By introducing Asp or isoAsp at susceptible Asn‐Gly sequences, we demonstrate that isoAsp17 formation specifically accelerates amyloid fibril formation, highlighting its potential contribution to dialysis‐related amyloidosis.
Ryuji Kawakami +5 more
wiley +2 more sources
Plant‐Based Production of Human Major Histocompatibility Complex Class II Molecules
Plant Biotechnology Journal, EarlyView.ABSTRACT Major histocompatibility complex class II (MHC II) protein triggers adaptive immune responses by presenting antigens on antigen‐presenting cells (APCs) to be recognised by CD4+ T cells. Recombinant MHC II proteins are effective for the analysis of peptide‐binding interaction, detection of antigen‐specific T‐cells and clinical testing for donor‐
Abdelaziz Ramadan +8 more
wiley +1 more source