Results 91 to 100 of about 75,241 (309)

Glutamate, Ornithine, Arginine, Proline, and Polyamine Metabolic Interactions: The Pathway Is Regulated at the Post-Transcriptional Level [PDF]

, 2016
The metabolism of glutamate into ornithine, arginine, proline, and polyamines is a major network of nitrogen-metabolizing pathways in plants, which also produces intermediates like nitric oxide, and γ-aminobutyric acid (GABA) that play critical roles in ...
Boubker eBarchi, Maegan eGagne, Rajtilak eMajumdar, Rakesh eMinocha, Stephanie eLong, Subhash C Minocha, Swathi eTurlapati, Swathi eTurlapati   +7 more
core   +4 more sources

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Synthetic amino acid-analogs of γ-aminobutyric acid

Bulletin of the Chemical Society of Ethiopia, 1989
Bull. Chem. Soc. Ethiop., 2(2) 57-60 (1989).
I.M. Ejimadu
doaj  

Identification of Escherichia coli K12 YdcW protein as a γ-aminobutyraldehyde dehydrogenase [PDF]

, 2005
γ-Aminobutyraldehyde dehydrogenase (ABALDH) from wild-type E. coli K12 was purified to apparent homogeneity and identified as YdcW by MS-analysis. YdcW exists as a tetramer of 202±29kDa in the native state, a molecular mass of one subunit was determined ...
Novikova, Anna E., Ptitsyn, Leonid R., Samsonova, Natalya N., Smirnov, Sergey V.   +3 more
core   +1 more source

Benefit from Biomass Boiler Emissions to Increase Greenhouse CO2 Levels for Optimal Growth and Yield in Tomato, Cucumber, and Strawberry

Advanced Energy and Sustainability Research, EarlyView.
Using CO2‐rich polluting gases in greenhouse plant cultivation has proven to be a promising technique for stimulating plants while reducing emissions to the atmosphere. The use of an experimental biofilter proves to be effective in retaining most of the toxic particles. The alteration of physiological and metabolic parameters shows an adaptation of the
Alberto Martinez‐Alonso, Jose Fermoso, Francisco Verdugo, Micaela Carvajal   +3 more
wiley   +1 more source

Negative modulation of the GABAAρ1 receptor function by l-cysteine [PDF]

, 2017
l-Cysteine is an endogenous sulfur-containing amino acid with multiple and varied roles in the central nervous system, including neuroprotection and the maintenance of the redox balance.
Beltrán González, Andrea Natalia, Calvo, Daniel Juan, Vicentini, Florencia   +2 more
core   +1 more source

Препаративний метод синтезу α,α-дифлуоро-γ-аміномасляної кислоти [PDF]

, 2020
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA).Results and discussion.
Bugera, Maksym Ya., Herbeda, Andrii V., Kondratov, Ivan S., Tarasenko, Karen V.   +3 more
core   +2 more sources

Research advances in dysphagia animal models

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai, Keling Cheng, Nannan Zhang, Yunfang Chen, Jun Ni, Zhiyong Wang   +5 more
wiley   +1 more source

Photo‐controlled Release of Urea Enables the Detection of Urea‐Urease Intermediates by cryo‐FTIR

Angewandte Chemie International Edition, Accepted Article.
Caged compounds are a valuable tool to photocontrol the release of enzymatic substrates in a reaction. For example, caged urea molecules were proposed to control urea delivery to urease reactions and aid the determination of the catalytic mechanism of this enzyme.
Caterina Netto, Sarah Bell, Caio B. Castro, Pedro Henrique Machado, Vatsal Purohit, Katherine M. Davis, Ana Paula L. Batista, R. Brian Dyer   +7 more
wiley   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source