Results 101 to 110 of about 83,248 (316)

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Study on γ-aminobutyric acid in bananas [PDF]

, 2002
筑波大学University of Tsukuba博士（理学）Doctor of Philosophy in Science2002【要旨 ...
43748, Chek, Sotha
core  

STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY

Разработка и регистрация лекарственных средств, 2019
The possibility of using the infrared spectra of the diffuse reflection in the near and medium field of standardization and optimization of the technological process of tablet forms of aliphatic amino acids: butyric, β-alanine, γ-aminobutyric acid. Shown
A. A. Maryin, I. G. Tansereva, Y. G. Chistohin   +2 more
doaj  

Co-operative Effect Between γ-Aminobutyric Acid A Receptors and Central-Type Benzodiazepine Receptors on Amylase Release in Rat Parotid Acinar Cells

Journal of Pharmacological Sciences, 2010
We investigated the inhibitory role of γ-aminobutyric acid A (GABA A ) receptors on amylase release and the evidence for functional coupling with central-type benzodiazepine receptors in rat parotid acinar cells.
Migiwa Okubo, Mitsuru Kawaguchi
doaj   +1 more source

Lilium davidii extract alleviates p‑chlorophenylalanine‑induced insomnia in rats through modification of the hypothalamic-related neurotransmitters, melatonin and homeostasis of the hypothalamic-pituitary-adrenal axis

Pharmaceutical Biology, 2020
Context Lilium davidii var. unicolour Cotton (Lilium genus, Liliaceae) is an edible plant and a herb used in China to alleviate insomnia. Objective To investigate the alleviating insomnia mechanism of L. davidii (LD).
Yanpo Si, Lili Wang, Jinxu Lan, Hanwei Li, Tao Guo, Xiaohui Chen, Chunhong Dong, Zhen Ouyang, Sui-qing Chen   +8 more
doaj   +1 more source

Safety and pharmacokinetics of a novel potent GABA analogue crisugabalin in Chinese subjects with various degrees of renal impairment

British Journal of Clinical Pharmacology, EarlyView.
Aims Crisugabalin is a novel calcium channel α2δ subunit ligand and a highly selective oral gamma‐aminobutyric acid (GABA) analogue developed for the treatment of diabetic peripheral neuropathic pain (DPNP) and postherpetic neuralgia (PHN). This study investigated pharmacokinetic properties and safety of crisugabalin in subjects with renal impairment ...
Shibeilei Lin, Ye Wang, Chao Hu, Yanhuan Feng, Xi Tang, Ping Fu, Jia Miao   +6 more
wiley   +1 more source

HPLC-based activity profiling for GABAA receptor modulators from the traditional Chinese herbal drug Kushen ( Sophora flavescens root) [PDF]

, 2018
An EtOAc extract from the roots of Sophora flavescens (Kushen) potentiated γ-aminobutyric acid (GABA)-induced chloride influx in Xenopus oocytes transiently expressing GABAA receptors with subunit composition, α 1 β 2 γ 2S.
Baburin, Igor, Hamburger, Matthias, Hering, Steffen, Plitzko, Inken, Yang, Xinzhou   +4 more
core  

Animal Toxicity of Hairpin Pyrrole-Imidazole Polyamides Varies with the Turn Unit [PDF]

, 2013
A hairpin pyrrole-imidazole polyamide (1) targeted to the androgen receptor consensus half-site was found to exert antitumor effects against prostate cancer xenografts.
Dervan, Peter B., Hamilton, Shari R., Li, Benjamin C., Meier, Jordan L., Nickols, Nicholas G., Szablowski, Jerzy O., Wang, Chieh-Mei, Yang, Fei   +7 more
core   +1 more source

γ-Aminobutyric AcidB(GABAB)-Receptor Mediation of Different In Vivo Effects of γ-Butyrolactone

Journal of Pharmacological Sciences, 2008
The endogenous brain constituent, γ-hydroxybutyric acid (GHB), as well as its prodrug, γ-butyrolactone (GBL), have recently gained interest in the drug addiction field due to their abuse potential and fatalities caused by overdose.
Mauro A.M. Carai, Carla Lobina, Paola Maccioni, Claudia Cabras, Giancarlo Colombo, Gian Luigi Gessa   +5 more
doaj   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source