Results 111 to 120 of about 75,241 (309)

Effects of ethylenediamine – a putative GABA-releasing agent – on rat hippocampal slices and neocortical activity in vivo [PDF]

, 2010
The simple diamine diaminoethane (ethylenediamine, EDA) has been shown to activate GABA receptors in the central and peripheral nervous systems, partly by a direct action and partly by releasing endogenous GABA.
Addae, J.I., Lui, C., Stone, T.W.
core   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Protective effect of kaempferol against cognitive and neurological disturbances induced by d-galactose and aluminum chloride in mice

Journal of Functional Foods, 2023
In this work, d-galactose/aluminum chloride (AlCl3)-treated mice with cognitive and neurological disturbances were administered kaempferol for 30 days.
He Lin, Xinhe Wang, Jiarui Zhao, Zhe Lin
doaj  

Identification of a Core Amino Acid Motif within the α Subunit of GABAARs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures [PDF]

, 2019
The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites.
Andrews, Peter M., Brandon, Nicholas J., Davies, Paul A., Hines, Rochelle M., Moore, Yvonne E., Moss, Stephen J., Nathanson, Anna J., Ollerhead, Thomas A., Rodriguez Santos, Miguel A., Smalley, Joshua L., Wobst, Heike J., Zhang, Yihui   +11 more
core   +1 more source

Synthetic epoxy-pregnan steroids: effects on anxiety behavior in rats [PDF]

, 2016
Neurosteroids like 3α-OH-5α-pregnan-20-one (allopregnanolone) and 3α-OH-5β-pregnan-20-one (pregnanolone) modulate the γ-aminobutyric acid-A (GABAA) receptor function and produce several effects that can be considered for therapeutical pruposes like ...
Coirini, Hector, Ghini, Alberto Antonio, Rey, Mariana   +2 more
core   +1 more source

Synthesis of Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐b]pyridazines by Multicomponent Reactions Using Green Solvents

European Journal of Organic Chemistry, EarlyView.
In an environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest, imidazo[1,2‐a]pyridine, imidazo[1,2‐a]pyrazine and imidazo[1,2‐b]pyridazine core structures are obtained by a multicomponent Groebke–Blackburn–Bienaymé reaction using bio‐based recyclable solvents.
Abdelkarim El Qami, Gatien Messire, Gaëtan Bouchery, Emma Caillet, Sloan Steiner, Sabine Berteina‐Raboin   +5 more
wiley   +1 more source

Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]

, 2011
GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo, Di Giovanni, Giuseppe, Errington, Adam C.   +2 more
core  

Contactless Conductivity Detection for Capillary Electrophoresis—Developments From 2020 to 2024

ELECTROPHORESIS, EarlyView.
ABSTRACT The review covering the development of capillary electrophoresis with capacitively coupled contactless conductivity detection from 2020 to 2024 is the latest in a series going back to 2004. The article considers applications employing conventional capillaries and planar lab‐on‐chip devices as well as fundamental and technical developments of ...
Peter C. Hauser, Pavel Kubáň
wiley   +1 more source

Involvement of upregulation of miR-210 in a rat epilepsy model

Neuropsychiatric Disease and Treatment, 2016
Licheng Chen, Hao Zheng, Shimeng Zhang Neurological Department of Internal Medicine, Linyi People’s Hospital of Shandong Province, Linyi, People’s Republic of China Abstract: Epilepsy is a common type of neurological disorder with ...
Chen L, Zheng H, Zhang S
doaj  

Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes

Neural Regeneration Research
Diabetic retinopathy is a prominent cause of blindness in adults, with early retinal ganglion cell loss contributing to visual dysfunction or blindness.
Yu-Qi Shao, Yong-Chen Wang, Lu Wang, Hang-Ze Ruan, Yun-Feng Liu, Ti-Hui Zhang, Shi-Jun Weng, Xiong-Li Yang, Yong-Mei Zhong   +8 more
doaj   +1 more source