Results 11 to 20 of about 75,241 (309)

GABA, γ-Aminobutyric Acid, Protects Against Severe Liver Injury [PDF]

Journal of Surgical Research, 2019
Acute liver failure (ALF) from severe acute liver injury is a critical condition associated with high mortality. The purpose of this study was to investigate the impact of preemptive administration of γ-aminobutyric acid (GABA) on hepatic injury and survival outcomes in mice with experimentally induced ALF.To induce ALF, C57BL/6NHsd mice were ...
Hata, Toshiyuki, Rehman, Fatima, Hori, Tomohide, Nguyen, Justin H.   +3 more
openaire   +4 more sources

INTERACTION OF Γ AMINOBUTYRIC ACID B RECEPTORS AND ELECTROMAGNETIC FIELD IN THE FEAR RESPONSE [PDF]

American Journal of Neuroscience, 2013
One of the most neurotransmission system consistently linked with fear response is GABAergic system. GABA through GABAB receptor can influence fear response. The aim of the present investigation was to examine the effect of IP injection of baclofen (GABAB agonist) and CGP35348 (GABAB antagonist) along with EMF exposure on frequency of fear response ...
M. Taherianfard, M. Fazeli, S. Karimi Haghighi, A. Bahaodini   +3 more
openaire   +2 more sources

Optimization Technology of Longshan Millet γ-amino Butyric Acid Enrichment Process by Neural Network Algorithm

Liang you shipin ke-ji, 2022
In order to promote the quality and efficiency improvement of Longshan millet industry and enhance the added value of products, this study took Longshan millet as the main raw material to learn the effects of soaking time, germination temperature and ...
ZHANG Yi-ming, HE Fa-tao, GE Bang-guo, GAO Ling   +3 more
doaj   +1 more source

An efficient process for co-production of γ-aminobutyric acid and probiotic Bacillus subtilis cells [PDF]

Food Science and Biotechnology, 2018
This study was to establish an integrated process for the co-production of γ-aminobutyric acid (GABA) and live probiotics. Six probiotic bacteria were screened and Bacillus subtilis ATCC 6051 showed the highest GABA-producing capacity. The optimal temperature and initial pH value for GABA production in B.
Fuchao Xu, Wei Zhang, Jinge Huang, Jixun Zhan, Jixun Zhan, Hongbo Wang, Hongbo Wang, Lei Sun   +7 more
openaire   +4 more sources

The preparative synthetic approach to α,α-difluoro-γ-aminobutyric acid

Журнал органічної та фармацевтичної хімії, 2020
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 2,2-difluoro-γ-aminobutyric acid, which is pharmacologically promising analog of γ-aminobutyric acid (GABA). Results and discussion.
Maksym Ya. Bugera, Andrii V. Herbeda, Karen V. Tarasenko, Ivan S. Kondratov   +3 more
doaj   +1 more source

THE EFFECTS OF NO-711 AND ß-ALANINE ON GLUTAMATE AND γ -AMINOBUTYRIC ACID UPTAKE BY NERVE TERMINALS ISOLATED FROM RATS AFTER PERINATAL HYPOXIA [PDF]

Biotechnologia Acta, 2015
The effects of highly-selective blocker of γ-aminobutyric acid transporters of GAT1, NO-711, and substrate inhibitor of γ aminobutyric acid transporters GAT3, ß-alanine on the initial velocity of L-[14C]glutamate and [3H]-γ-aminobutyric acid uptake by ...
Dudarenko M. V., Yatsenko L. M., Piskova M. V., Nazarova A. G., Voronova O. O., Pastukhov A. O, Pozdnyakova N. G.   +6 more
doaj   +1 more source

Effect of Exogenous γ-Aminobutyric Acid on the Quality and γ-Aminobutyric Acid Metabolism of Fresh-cut Pumpkins

Shipin gongye ke-ji, 2022
The effect of exogenous γ-aminobutyric acid (GABA) and GABA synthesis inhibitor 3-mercaptopropionic acid (3-MP) on GABA metabolism and quality in fresh-cut pumpkin was investigated, and the possible mechanism was studied.
Jingyi LIANG, Fan GUO, Ke ZHAO, Hongfei WANG, Feng XU   +4 more
doaj   +1 more source

γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins [PDF]

Journal of Biological Chemistry, 2012
α-Conotoxins Vc1.1 and RgIA are small peptides isolated from the venom of marine cone snails. They have effective anti-nociceptive actions in rat models of neuropathic pain. Pharmacological studies in rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (Ca(v)2.2) calcium channels via a pathway involving γ ...
Cuny, Hartmut, De Faoite, Andrew, Huynh, Thuan G., Yasuda, Takahiro, Berecki, Géza, Adams, David J.   +5 more
openaire   +4 more sources

Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli [PDF]

Journal of Biological Engineering, 2019
Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG) or L-glutamic acid (L-Glu) by glutamate decarboxylase (GAD; EC4.1.1.15).
Gongnian Xiao, Haina Yuan, Haina Yuan, Jixun Zhan, Yong Qin, Hongbo Wang, Ozkan Fidan   +6 more
openaire   +5 more sources

Ezrin Mediates Tethering of the γ-Aminobutyric Acid Transporter GAT1 to Actin Filaments Via a C-Terminal PDZ-Interacting Domain [PDF]

Biophysical Journal, 2009
A high density of neurotransmitter transporters on axons and presynaptic boutons is required for the efficient clearance of neurotransmitters from the synapse. Therefore, regulators of transporter trafficking (insertion, retrieval, and confinement) can play an important role in maintaining the transporter density necessary for effective function.
Imoukhuede, P. I., Moss, Fraser J., Michael, Darren J., Chow, Robert H., Lester, Henry A.   +4 more
openaire   +5 more sources