Results 211 to 220 of about 75,241 (309)

From the gut to the brain, mechanisms and clinical applications of γ-aminobutyric acid (GABA) on the treatment of anxiety and insomnia. [PDF]

Front Neurosci
Jiang C, Chen Y, Sun T.
europepmc   +1 more source

Patient‐Derived Cortical Organoids Reveal Senescence of Neural Progenitor Cells in Hutchinson‐Gilford Progeria Syndrome

Aging Cell, EarlyView.
HGPS patient‐derived cortical organoids exhibit progerin accumulation, nuclear abnormalities, and increased senescence in rosette structures, leading to impaired neuronal differentiation and altered gene expression. ABSTRACT Hutchinson‐Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by premature aging and primarily caused by ...
Seeun Jeon, Chul‐Sung Park, Juyoung Hong, Jieun Kim, Yun Jin Lee, Junho K. Hur, Ji Yeoun Lee   +6 more
wiley   +1 more source

Effect of γ‑Aminobutyric Acid–Chitosan Nanoparticles on Glucose Homeostasis in Mice

ACS Omega, 2018
Yuangang Liu, Weiji Weng, Shibin Wang, Ruimin Long, Hanwen Li, Huihui Li, Tengteng Li, Mengyi Wu   +7 more
doaj   +1 more source

Unveiling the potential biochemical effects of selected heterocyclic compounds as human Type-A γ-aminobutyric acid (GABA A) Modulator: An <i>Insilico</i> Approach. [PDF]

Biotechnol Rep (Amst)
Oyebamiji AK, Akintelu SA, Ebenezer O, Olujinmi FE, Adekunle DO, Olanrewaju AA, Akinola OT, Afolabi SO, Erazua EA, Olaseinde AA.   +9 more
europepmc   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Optimization of γ-Aminobutyric Acid Production in Brown Rice via Prolonged Seed Priming. [PDF]

Plants (Basel)
Xu L, Wang X, Li Q, Niu Y, Ding G, He J, Chen W, Tian D.   +7 more
europepmc   +1 more source

Bumetanide Treatment in 15 Children With Autism: A Randomised Waitlist‐Control Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Bumetanide, a diuretic, influences neuronal chloride homeostasis and potentially restores GABAergic inhibition and neuronal signalling balance. This mechanism may contribute to improvements in autism‐related symptoms. The present study builds on the preclinical research and on previous clinical research on bumetanide treatment for children
Elisabeth Fernell, Sara Landberg, Carmela Miniscalco, Rosanna Fagerudd, Jakob Åsberg Johnels, Mats Johnson, Nouchine Hadjikhani, Christopher Gillberg   +7 more
wiley   +1 more source

The Regulation of γ-Aminobutyric Acid on Antioxidative Defense Response of Pacific Oyster upon High-Temperature Stress. [PDF]

Antioxidants (Basel)
Liu R, Gao L, Zhang X, Ge P, Wang L, Zhou K, Yang C, Wang L, Song L.   +8 more
europepmc   +1 more source

Stereological analysis of cholinergic neurons within bilateral pedunculopontine nuclei in health and when affected by Parkinson's disease

Brain Pathology, EarlyView.
(A) PPN‐cholinergic neurons degenerate during PD. We stereologically counted their rostro‐caudal distribution in post‐mortem PPNs in health versus PD. (Bi) Serial PPN‐containing samples were cholinergic antibody‐DAB stained. (Bii) Only DAB‐stained neurons on green lines and inside the box were counted.
Puneet Kumar Sharma, Steve Gentleman, David Trevor Dexter, Ilse Sanet Pienaar   +3 more
wiley   +1 more source

Regulation of γ‐Aminobutyric Acid Synthesis in the Brain [PDF]

, 1993
David L. Martin, Karin Rimvall
openalex   +1 more source