Results 221 to 230 of about 83,248 (316)

Targeting γ-aminobutyric acid pathways in irritable bowel syndrome: bridging central nervous system, enteric dysfunction, and the microbiota-gut-brain axis. [PDF]

Front Pharmacol
Lambiase C, Rettura F, Sciumè GD, Tedeschi R, Grosso A, Cancelli L, Bottari A, Fornai M, Antonioli L, de Bortoli N, Bellini M.   +10 more
europepmc   +1 more source

14‐3‐3σ up‐regulation in the temporal cortex associates with tau pathology and reactive astroglia in Lewy body disorders

Brain Pathology, EarlyView.
14‐3‐3 protein homeostasis is disrupted in Lewy body pathology, showing a diminution of six isotypes and overexpression of stratifin. The latter was associated with stratifin colocalization with tau pathology and reactive astrocytes. Platelets, as a peripheral biomarker source, mirrored inversely cortical 14‐3‐3 gene expression patterns in dementia ...
Laura Marsal‐García, Jorge Mena, Carol‐Ann Lao, David Adamuz, Laura Arnaldo, Cristina Carrato, Alex Menendez, Daniela Samaniego, Dolores Vilas, Lourdes Ispierto, Anna Planas, Ramiro Alvarez, Pau Pastor, Katrin Beyer   +13 more
wiley   +1 more source

Strategies to Improve γ-Aminobutyric Acid Biosynthesis in Rice via Optimal Conditions. [PDF]

Plants (Basel)
Shen L, Yang Y, Liu X, Zhao H, Zhang Y, Shen L, Zhu L, Hu J, Ren D, Zhang Q, Gao Z, Dong G, Li Q, Qian Q, Zeng D, Zhang G.   +15 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

kcnb1 loss of function in zebrafish causes neurodevelopmental and epileptic disorders associated with γ-aminobutyric acid dysregulation. [PDF]

Epilepsia
Robichon L, Bar C, Marian A, Lehmann L, Renault S, Kabashi E, Ciura S, Nabbout R.   +7 more
europepmc   +1 more source

Midazolam Administration Reverses Thermal Hyperalgesia and Prevents γ-Aminobutyric Acid Transporter Loss in a Rodent Model of Neuropathic Pain

, 2008
Andre Shih, Vjekoslav Miletić, Gordana Miletić, Lesley J. Smith   +3 more
openalex   +1 more source

Complex Formation with the Type B γ-Aminobutyric Acid Receptor Affects the Expression and Signal Transduction of the Extracellular Calcium-sensing Receptor [PDF]

, 2007
Wenhan Chang, Chia‐Ling Tu, Zhiqiang Cheng, Luis A. Rodríguez, Tsui‐Hua Chen, Martin Gassmann, Bernhard Bettler, Marta Margeta, Lily Yeh Jan, Dolores Shoback   +9 more
openalex   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

A Comparison of the Effects of Phycocyanin, γ-Aminobutyric Acid, Glycine Betaine, and Mycorrhizal Biostimulants of Non-Stressed <i>Agrostis stolonifera</i>. [PDF]

Plants (Basel)
Suárez IDS, Hsiang T, Goodwin PH.
europepmc   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source