Results 271 to 280 of about 83,248 (316)

Enhancing High-Level Food-Grade Expression of Glutamate Decarboxylase and Its Application in the Production of γ-Aminobutyric Acid. [PDF]

J Microbiol Biotechnol
Zhang K, Lv H, Yu X, Zhu X, Chen S, Wu J.   +5 more
europepmc   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, EarlyView.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

Physiology of γ-aminobutyric acid production by Akkermansia muciniphila. [PDF]

Appl Environ Microbiol
Konstanti P, Ligthart K, Fryganas C, Constantinos P, Smidt H, de Vos WM, Belzer C.   +6 more
europepmc   +1 more source

WONOEP XVII appraisal: The immunopathogenesis of epilepsy

Epilepsia, EarlyView.
Abstract There is a wealth of data indicating that the immune system plays an important role in seizure disorders. This includes autoimmune encephalitis, in which an immune response directed against neuronal antigens results in brain inflammation and subsequent seizure activity, as well as autoimmune‐associated epilepsy and neuroinflammatory changes ...
Nihan Çarçak, Said Al Maawal, Peravina Thergarajan, Tracie H. L. Tan, Vinod Kumar Mehta, Tamara Baker, David C. Henshall, Aristea S. Galanopoulou, Özlem Akman, Pablo M. Casillas‐Espinosa, Raman Sankar, Laura Librizzi, Adam E. Handel   +12 more
wiley   +1 more source

Inhibitory Actions of Potentiating Neuroactive Steroids in the Human α1β3γ2L γ-Aminobutyric Acid Type A Receptor. [PDF]

Mol Pharmacol
Pierce SR, Germann AL, Covey DF, Evers AS, Steinbach JH, Akk G.   +5 more
europepmc   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Screening of LAB strains and their co-culture fermentation with <i>Bacillus subtilis</i> of Cili fruit substrate: impact on γ-aminobutyric acid enrichment, key enzyme activities, bioactive and functional properties. [PDF]

Front Nutr
Uriho A, Omedi JO, Chen C, Chen K, Zhang S, Liang L, Xu Y, Li N, Huang W.   +8 more
europepmc   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source

Dietary γ-Aminobutyric Acid Promotes Growth and Immune System Performance and Improves Erythropoiesis and Angiogenesis in Gibel Carp (Carassius auratus gibelio). [PDF]

Animals (Basel)
Bai X, Zhang L, Liang H, Huang D, Ren M, Mi H.   +5 more
europepmc   +1 more source

High-efficiency γ-aminobutyric acid nano-formulation for turnip mosaic virus: excellent adhesion performance and amplified plant defensive responses

Chao Zhang, Jingyi Chen, Yuquan Wen, Yichao Liu, Xuan Li, Shuo Yan, Jianjun Zhao, Jun Li   +7 more
openalex   +1 more source