Results 21 to 30 of about 172,175 (356)

Identification of naturally originated molecules as γ-aminobutyric acid receptor antagonist

Journal of Biomolecular Structure and Dynamics, 2020
γ-aminobutyric acid, being a principle neuromediator in humans controlling the inhibition signals, acts on the ligand-gated pentameric type A receptors to transmit their response.
Jatin Sharma, Vijay Kumar Bhardwaj, P. Das, Rituraj Purohit   +3 more
semanticscholar   +1 more source

Effect of Exogenous γ-Aminobutyric Acid on the Quality and γ-Aminobutyric Acid Metabolism of Fresh-cut Pumpkins

Shipin gongye ke-ji, 2022
The effect of exogenous γ-aminobutyric acid (GABA) and GABA synthesis inhibitor 3-mercaptopropionic acid (3-MP) on GABA metabolism and quality in fresh-cut pumpkin was investigated, and the possible mechanism was studied.
Jingyi LIANG, Fan GUO, Ke ZHAO, Hongfei WANG, Feng XU   +4 more
doaj   +1 more source

γ-Aminobutyric Acid Type B (GABAB) Receptor Expression Is Needed for Inhibition of N-type (Cav2.2) Calcium Channels by Analgesic α-Conotoxins [PDF]

Journal of Biological Chemistry, 2012
α-Conotoxins Vc1.1 and RgIA are small peptides isolated from the venom of marine cone snails. They have effective anti-nociceptive actions in rat models of neuropathic pain. Pharmacological studies in rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (Ca(v)2.2) calcium channels via a pathway involving γ ...
Cuny, Hartmut, De Faoite, Andrew, Huynh, Thuan G., Yasuda, Takahiro, Berecki, Géza, Adams, David J.   +5 more
openaire   +4 more sources

Identification of new glutamate decarboxylases from Streptomyces for efficient production of γ-aminobutyric acid in engineered Escherichia coli [PDF]

Journal of Biological Engineering, 2019
Gamma (γ)-Aminobutyric acid (GABA) as a bioactive compound is used extensively in functional foods, pharmaceuticals and agro-industry. It can be biosynthesized via decarboxylation of monosodium glutamate (MSG) or L-glutamic acid (L-Glu) by glutamate decarboxylase (GAD; EC4.1.1.15).
Gongnian Xiao, Haina Yuan, Haina Yuan, Jixun Zhan, Yong Qin, Hongbo Wang, Ozkan Fidan   +6 more
openaire   +5 more sources

Ezrin Mediates Tethering of the γ-Aminobutyric Acid Transporter GAT1 to Actin Filaments Via a C-Terminal PDZ-Interacting Domain [PDF]

Biophysical Journal, 2009
A high density of neurotransmitter transporters on axons and presynaptic boutons is required for the efficient clearance of neurotransmitters from the synapse. Therefore, regulators of transporter trafficking (insertion, retrieval, and confinement) can play an important role in maintaining the transporter density necessary for effective function.
Imoukhuede, P. I., Moss, Fraser J., Michael, Darren J., Chow, Robert H., Lester, Henry A.   +4 more
openaire   +5 more sources

A Single Phenylalanine Residue in the Main Intracellular Loop of α1 γ-Aminobutyric Acid Type A and Glycine Receptors Influences Their Sensitivity to Propofol [PDF]

Anesthesiology, 2011
Background The intravenous anesthetic propofol acts as a positive allosteric modulator of glycine (GlyRs) and γ-aminobutyric acid type A (GABAARs) receptors. Although the role of transmembrane residues is recognized, little is known about the involvement of other regions in the modulatory effects of propofol.
Moraga-Cid, Gustavo, Yevenes, Gonzalo E., Schmalzing, Günther, Peoples, Robert W., Aguayo, Luis G.   +4 more
openaire   +5 more sources

γ-Aminobutyric acid (GABA) and ectoine (ECT) impacts with and without AMF on antioxidants, gas exchange attributes and nutrients of cotton cultivated in salt affected soil

BMC Plant Biology, 2023
Salinity stress is one of the major hurdles in agriculture which adversely affects crop production. It can cause osmotic imbalance, ion toxicity that disrupts essential nutrient balance, impaired nutrient uptake, stunted growth, increased oxidative ...
Yuhan Ma, Ping Huang, Shoucheng Huang, Uzma Younis, Ghulam Sabir Hussain, Shah Fahad, Subhan Danish, Mohamed Soliman Elshikh, Humaira Rizwana   +8 more
doaj   +1 more source

Electroacupuncture Improves Baroreflex and γ-Aminobutyric Acid Type B Receptor-Mediated Responses in the Nucleus Tractus Solitarii of Hypertensive Rats [PDF]

Neural Plasticity, 2018
Electroacupuncture (EA) has been reported to benefit hypertension, but the underlying mechanisms are still unclear. We hypothesized that EA attenuates hypertension, in part, through modulation of γ-aminobutyric acid (GABA) receptor function in the nucleus tractus solitarii (NTS).
Qi Zhang, Ying-Ying Tan, Xiao-hua Liu, Fan-Rong Yao, Dong-Yuan Cao   +4 more
openaire   +4 more sources

Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons [PDF]

, 1984
Carbachol and γ-aminobutyric acid depolarize mammalian sympathetic neurons and increase the free extracellular K+-concentration. We have used double-barrelled ion-sensitive microelectrodes to determine changes of the membrane potential and of the free ...
Ballanyi, Klaus, Grafe, Peter, Reddy, M. M., Ten Bruggencate, Gerrit   +3 more
core   +1 more source

Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. [PDF]

, 2012
Photochemical switches represent a powerful method for improving pharmacological therapies and controlling cellular physiology. Here we report the photoregulation of GABA(A) receptors (GABA(A)Rs) by a derivative of propofol (2,6-diisopropylphenol), a ...
Bruzik, Karol S, Dellal, Shlomo S, Feng, Feng, Otis, Thomas S, Pawlowski, Michal, Pepperberg, David R, Qian, Haohua, Xie, An, Yue, Lan   +8 more
core   +2 more sources