Results 31 to 40 of about 83,248 (316)

The effects of hypothermia on glutamate and γ-aminobutyric acid metabolism during ischemia in monkeys: a repeated-measures ANOVA study

Scientific Reports, 2022
During an ischemic stroke, the brain releases various factors, including glutamate and γ-aminobutyric acid. Glutamate can cause neurotoxic effects through certain receptors and exacerbate neurological damage, while γ-aminobutyric acid as an inhibitory ...
Bo-hu Liu, Jun Pu, Ze-qi Li, Xiao-ran Zhang   +3 more
doaj   +1 more source

Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]

, 2014
BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
core   +2 more sources

Study on Processing Technology and Quality of Moringa oleifera leaves with y - Aminobutyric Acid

MATEC Web of Conferences, 2017
In order to obtain the high level of γ-aminobutyric acid Moringa oleifera leaves, Use 7% sodium glutamate solution to soak the fresh Moringa oleifera leaves, study effect of different treatment times and three different drying methods( hot air drying ...
Wei Zhou, Qian Li, Changqing Guo, Yupo Cao, Shaodan Peng, Wei Jing, Jihua Li   +6 more
doaj   +1 more source

Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance

Plants, 2021
The signaling role for γ-Aminobutyric acid (GABA) has been documented in animals for over seven decades. However, a signaling role for GABA in plants is just beginning to emerge with the discovery of putative GABA binding site/s and GABA regulation of ...
Mona Kaspal, Madhuka H. Kanapaddalagamage, Sunita A. Ramesh   +2 more
doaj   +1 more source

Sedative-like effect of intraperitoneal GABA administration in the open field test [PDF]

, 2016
Gamma-Amino Butyric Acid (GABA) is the main inhibitor neurotransmitter of the Central Nervous System (CNS). Its peripheral administration has been matter of discussion. On the one hand, it has been reported that it does not cross the Blood-Brain Barrier (
Gargiulo, Augusto Pascual Ítalo, Gargiulo, Pascual Angel, Guevara, Manuel Alejandro, Lafuente, José Vicente, Landa, Adriana Inés, Marquez Herrero, Santiago, Mesones, Humberto Luis, Romanowicz, Esteban Alejandro   +7 more
core   +1 more source

Digitization of multistep organic synthesis in reactionware for on-demand pharmaceuticals [PDF]

, 2018
Chemical manufacturing is often done at large facilities that require a sizable capital investment and then produce key compounds for a finite period. We present an approach to the manufacturing of fine chemicals and pharmaceuticals in a self-contained ...
Cronin, Leroy, Francoia, Jean-Patrick, Kitson, Philip J., Marie, Guillaume, Mathieson, Jennifer S., Sigerson, Ralph C., Zalesskiy, Sergey S.   +6 more
core   +1 more source

Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1

Biology, 2022
Plant-derived pharmacological agents have been used extensively to dissect the structure–function relationships of mammalian GABA receptors and ion channels. Picrotoxin is a non-competitive antagonist of mammalian GABAA receptors.
Sunita A. Ramesh, Yu Long, Abolfazl Dashtbani-Roozbehani, Matthew Gilliham, Melissa H. Brown, Stephen D. Tyerman   +5 more
doaj   +1 more source

Research progress of manganese exposure on abnormal GnRH release in hypothalamus affecting reproductive function

环境与职业医学, 2023
Manganese plays an important physiological role in the organism, and excessive manganese exposure can cause impairment of neurological and reproductive functions.
Huan MAO, Yan LI
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Non-Targeted Metabolomics Analysis of γ–Aminobutyric Acid Enrichment in Germinated Maize Induced by Pulsed Light

Foods
Pulsed light is an emerging technique in plant physiology recognized for its ability to enhance germination and accumulate γ–aminobutyric acid in maize.
Liangchen Zhang, Xiaojing Liu, Liwei Xu, Mengxi Xie, Miao Yu   +4 more
doaj   +1 more source