Results 31 to 40 of about 75,241 (309)

Beyond the γ-aminobutyric acid hypothesis of schizophrenia

Frontiers in Cellular Neuroscience, 2023
Abnormalities in the γ-aminobutyric acid (GABA) system have been reported in the postmortem brains of individuals with schizophrenia. In particular, the reduction of one of the GABA-synthesizing enzymes, the 67-kDa isoform of glutamate decarboxylase ...
Kazuyuki Fujihara, Kazuyuki Fujihara
doaj   +1 more source

Differential localization of γ‐aminobutyric acid type a and glycine receptor subunits and gephyrin in the human pons, medulla oblongata and uppermost cervical segment of the spinal cord: An immunohistochemical study

Journal of Comparative Neurology, 2009
AbstractGephyrin is a multifunctional protein responsible for the clustering of glycine receptors (GlyR) and γ‐aminobutyric acid type A receptors (GABAAR). GlyR and GABAAR are heteropentameric chloride ion channels that facilitate fast‐response, inhibitory neurotransmission in the mammalian brain and spinal cord. We investigated the immunohistochemical
Louise F.B. Nicholson, Henry J. Waldvogel, Richard L.M. Faull, Kathryn L. Allen, Mark I. Rees, Mark I. Rees, H. Möhler, Kristin Baer, E Eady, Raymond Gilbert   +9 more
openaire   +5 more sources

The use of deuterium-labeled gamma-aminobutyric (D6-GABA) to study uptake, translocation, and metabolism of exogenous GABA in plants

Plant Methods, 2020
Background Exogenous application of gamma-aminobutyric acid (GABA) could relieve stress symptoms caused by abiotic stresses including anoxia, heat and cold shock, drought, and salt.
Faraj Hijaz, Nabil Killiny
doaj   +1 more source

The effects of hypothermia on glutamate and γ-aminobutyric acid metabolism during ischemia in monkeys: a repeated-measures ANOVA study

Scientific Reports, 2022
During an ischemic stroke, the brain releases various factors, including glutamate and γ-aminobutyric acid. Glutamate can cause neurotoxic effects through certain receptors and exacerbate neurological damage, while γ-aminobutyric acid as an inhibitory ...
Bo-hu Liu, Jun Pu, Ze-qi Li, Xiao-ran Zhang   +3 more
doaj   +1 more source

Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue

Molecular Genetics and Metabolism Reports, 2015
Methylenetetrahydrofolate reductase (MTHFR) is an enzyme key regulator in folate metabolism. Deficiencies in MTHFR result in increased levels of homocysteine, which leads to reduced levels of S-adenosylmethionine (SAM).
N.M. Jadavji, F. Wieske, U. Dirnagl, C. Winter   +3 more
doaj   +1 more source

Ro 15-4513 Antagonizes Alcohol-Induced Sedation in Mice Through aß¿2-type GABA(A) Receptors [PDF]

, 2011
Peer reviewedPublisher ...
Korpi, Esa R, Leppä, Elli, Linden, Anni-Maija, Lüddens, Hartmut, Schmitt, Ulrich, Wisden, William, Wulff, Peer   +6 more
core   +3 more sources

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source

Study on Processing Technology and Quality of Moringa oleifera leaves with y - Aminobutyric Acid

MATEC Web of Conferences, 2017
In order to obtain the high level of γ-aminobutyric acid Moringa oleifera leaves, Use 7% sodium glutamate solution to soak the fresh Moringa oleifera leaves, study effect of different treatment times and three different drying methods( hot air drying ...
Wei Zhou, Qian Li, Changqing Guo, Yupo Cao, Shaodan Peng, Wei Jing, Jihua Li   +6 more
doaj   +1 more source

Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit [PDF]

, 2008
The characterization of a new class of pyrrole−imidazole hairpin polyamides with β-amino-γ-turn units for recognition of the DNA minor groove is reported.
Chenoweth, David M., Dervan, Peter B., Dose, Christian, Farkas, Michelle E.   +3 more
core   +2 more sources

Research progress of manganese exposure on abnormal GnRH release in hypothalamus affecting reproductive function

环境与职业医学, 2023
Manganese plays an important physiological role in the organism, and excessive manganese exposure can cause impairment of neurological and reproductive functions.
Huan MAO, Yan LI
doaj   +1 more source