Results 51 to 60 of about 172,175 (356)

Sedative-like effect of intraperitoneal GABA administration in the open field test [PDF]

, 2016
Gamma-Amino Butyric Acid (GABA) is the main inhibitor neurotransmitter of the Central Nervous System (CNS). Its peripheral administration has been matter of discussion. On the one hand, it has been reported that it does not cross the Blood-Brain Barrier (
Gargiulo, Augusto Pascual Ítalo, Gargiulo, Pascual Angel, Guevara, Manuel Alejandro, Lafuente, José Vicente, Landa, Adriana Inés, Marquez Herrero, Santiago, Mesones, Humberto Luis, Romanowicz, Esteban Alejandro   +7 more
core   +1 more source

Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1

Biology, 2022
Plant-derived pharmacological agents have been used extensively to dissect the structure–function relationships of mammalian GABA receptors and ion channels. Picrotoxin is a non-competitive antagonist of mammalian GABAA receptors.
Sunita A. Ramesh, Yu Long, Abolfazl Dashtbani-Roozbehani, Matthew Gilliham, Melissa H. Brown, Stephen D. Tyerman   +5 more
doaj   +1 more source

Multiple functional neurosteroid binding sites on GABAA receptors [PDF]

, 2019
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav, Bracamontes, John R, Budelier, Melissa M, Chen, Zi-Wei, Cheng, Wayland W. L., Covey, Douglas F, Evers, Alex S, Germann, Allison L, Kathiresan, Krishnan, Manion, Brad, Qian, Ming-Xing, Reichert, David E, Shin, Daniel J   +12 more
core   +3 more sources

Characterization of a Potential Probiotic Lactobacillus brevis RK03 and Efficient Production of γ-Aminobutyric Acid in Batch Fermentation

International Journal of Molecular Sciences, 2018
Lactic acid bacteria were isolated from fish and evaluated for their γ-aminobutyric acid (GABA)-producing abilities. Out of thirty-two isolates, Lactobacillus brevis RK03 showed the highest GABA production ability.
Chien-Hui Wu, Yi-Huang Hsueh, J. Kuo, Sitao Liu   +3 more
semanticscholar   +1 more source

Effects of Different Treatments on Nutritional Composition and Antioxidant Activity of Rice Buckwheat

Shipin gongye ke-ji, 2022
In order to study the influence of different treatment methods on the nutritional composition and biological activity of rice buckwheat, germination, fermentation, steaming and fermentation after steaming on the reducing sugar, protein, free amino acids,
Jing YAN, Yixi CAI, Qiuyan XUE, Junjian LI, Pan LI, Bing DU   +5 more
doaj   +1 more source

Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]

, 2014
Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J, Hare, Emma B, Lozano, Reymundo   +2 more
core   +1 more source

Chronic antipsychotic treatment differentially modulates protein kinase A- and glycogen synthase kinase 3 beta-dependent signaling pathways, N-methyl-D-aspartate receptor and γ-aminobutyric acid A receptors in nucleus accumbens of juvenile rats

Journal of Psychopharmacology, 2018
Background: Antipsychotics are developed to treat mental disorders in adults; however, the prescription (mostly “off-label”) of antipsychotics for children/adolescents has been constantly increasing over years. The influences of antipsychotics on juveniles requires investigation to validate their clinic use.
Jiamei Lian, Bo Pan, Chao Deng, Chao Deng   +3 more
openaire   +5 more sources

Non-Targeted Metabolomics Analysis of γ–Aminobutyric Acid Enrichment in Germinated Maize Induced by Pulsed Light

Foods
Pulsed light is an emerging technique in plant physiology recognized for its ability to enhance germination and accumulate γ–aminobutyric acid in maize.
Liangchen Zhang, Xiaojing Liu, Liwei Xu, Mengxi Xie, Miao Yu   +4 more
doaj   +1 more source

Research progress of manganese exposure on abnormal GnRH release in hypothalamus affecting reproductive function

环境与职业医学, 2023
Manganese plays an important physiological role in the organism, and excessive manganese exposure can cause impairment of neurological and reproductive functions.
Huan MAO, Yan LI
doaj   +1 more source

Development and Techno-Economic Evaluation of Crystallization Techniques for GABA Purification from Fermentation Broth

Molecules
γ-aminobutyric acid, a critical neurotransmitter, is experiencing an increasing demand in the medical and health fields. Conventional processes for γ-aminobutyric acid purification from fermentation broth encounter significant challenges, such as high ...
Yu Jing, Jinxu Zhang, Shengping You, Mengfan Wang, Rongxin Su, Wei Qi   +5 more
doaj   +1 more source