Results 71 to 80 of about 83,248 (316)
Advanced Science, EarlyView.An Automated ex vivo culture system BaSIC, tailored for SCN slices and cell culture, which automates medium exchange and ensures a stable internal environment is developed. BaSIC enables real‐time observation of tissue/cell responses to diverse but programmed stimuli.
Kui Han +7 more
wiley +1 more source
康复学报, 2023 ObjectiveAnimal magnetic resonance spectroscopy (MRS) imaging was used to detect the level of glutamate and γ-aminobutyric acid in motor cortex of rats, and to explore the regulatory effect of constraint-induced movement therapy (CIMT) on motor function ...
JIANG Pingli +5 more
doaj
Advanced Science, EarlyView.Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian +5 more
wiley +1 more source
Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats [PDF]
, 2015 Spreading depression (SD), discovered by Leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes.
Alizadeh, L., Ghaemi, A., Lotfinia, A.A.
core
Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]
, 2018 There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa +4 more
core +3 more sources
The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia
Advanced Science, EarlyView.The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo +3 more
wiley +1 more source
Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
core
NMR characterization of hairpin polyamide complexes with the minor groove of DNA [PDF]
, 1997 Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA.
Dervan, Peter B. +4 more
core +1 more source
Research Progress of γ-Aminobutyric Acid (GABA)
Shipin gongye ke-jiγ-aminobutyric acid (GABA) is a non-protein amino acid discovered in animals, plants, and microorganisms that was approved as the "new resource food" by the National Health Commission of the People's Republic of China (NHC) in 2009.
Junping ZHOU +7 more
doaj +1 more source
Acidification and γ-aminobutyric acid independently alter kairomone-induced behaviour [PDF]
Royal Society Open Science, 2016 Exposure to high pCO2 or low pH alters sensation and behaviour in many marine animals. We show that crab larvae lose their ability to detect and/or process predator kairomones after exposure to low pH over a time scale relevant to diel pH cycles in ...
Corie L. Charpentier +1 more
doaj +1 more source