Results 71 to 80 of about 75,241 (309)
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Multiple functional neurosteroid binding sites on GABAA receptors [PDF]
, 2019 Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases.
Akk, Gustav +12 more
core +3 more sources
Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Study on γ-aminobutyric acid in bananas [PDF]
, 2002 筑波大学University of Tsukuba博士（理学）Doctor of Philosophy in Science2002【要旨 ...
43748, Chek, Sotha
core
Modulation of the GABAergic pathway for the treatment of fragile X syndrome. [PDF]
, 2014 Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation ...
Hagerman, Randi J +2 more
core +1 more source
Heterointerface‐Modulated Synthetic Synapses Exhibiting Complex Multiscale Plasticity
Advanced Science, EarlyView.An asymmetric dual‐gate heterointerface‐regulated artificial synapse (HRAS) is developed, employing distinct ion concentrations and dielectric coupling to form precise dual‐interface channels. Through lateral modulation, HRAS realizes, for the first time, the intricate interplay of lateral inhibition/enhancement and multi‐level short‐ and long‐term ...
Xingji Liu +14 more
wiley +1 more source
Isolation and identification of Monascus strains and its degradation treatment of pit bottom wastewater of the sauce-flavor Baijiu byproduct [PDF]
Zhongguo niangzaoTo obtain Monascus spp. with high efficiency in degrading pit bottom wastewater from sauce-flavor (Jiangxiangxing) Baijiu production, Monascus strains were screened from sauce-flavor Baijiu Daqu using traditional cultivation methods and identified ...
LI Xuanchen, YANG Xin, CHENG Mai, LUO Yuena, ZHOU Jianli, QIU Shuyi
doaj +1 more source
Frontiers in Microbiology, 2023 IntroductionGanmai Dazao Decoction is a traditional Chinese recipe, and is composed of licorice, floating wheat, and jujube.MethodsEffects of lactic acid bacteria fermentation on the physicochemical properties, antioxidant activity, and γ-aminobutyric ...
Linya Wei +9 more
doaj +1 more source
Constitutive expression of the UGA4 gene in Saccharomyces cerevisiae depends on two positive-acting proteins, Uga3p and Uga35p [PDF]
, 2000 The first specific precursor of porphyrin biosynthesis is δ-aminolevulinic acid. δ-Aminolevulinic acid enters Saccharomyces cerevisiae cells through the γ-aminobutyric acid specific permease Uga4p.
Batlle, A., Garcia, S.C., Moretti, M.B.
core
The voltage-gated potassium channel Shaker promotes sleep via thermosensitive GABA transmission [PDF]
, 2020 Genes and neural circuits coordinately regulate animal sleep. However, it remains elusive how these endogenous factors shape sleep upon environmental changes.
Baik, Bukyung +7 more
core +1 more source