Results 81 to 90 of about 83,248 (316)

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Stereochemical control of the DNA binding affinity, sequence specificity, and orientation preference of chiral hairpin polyamides in the minor groove [PDF]

, 1998
Three-ring polyamides containing pyrrole (Py) and imidazole (Im) amino acids covalently coupled by γ-aminobutyric acid (γ) form six-ring hairpins that recognize five-base-pair sequences in the minor groove of DNA.
Baird, Eldon E., Dervan, Peter B., Herman, David M.   +2 more
core   +1 more source

Effect of different conditions on the germination of coix seed and its characteristics analysis

Food Chemistry: X
Coix seed (CS) has high nutritional value, but the deep processing of CS is relatively limited. Sprouting can significantly improve nutritional value, laying the foundation for efficient consumption or further processing.
Lidan Dong, Yun Yang, Yongcai Zhao, Zhengyu Liu, Cuiqin Li, Laping He, Lihua Liu   +6 more
doaj   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation [PDF]

, 2001
Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks.
A. Bibbig, A. Caputi, Ali, Angulo, Aroniadou, Asada, Bonnerot, Buhl, Catania, Catania, Csicsvari, E. C. Fuchs, Erlander, Ermentrout, Esclapez, Geiger, Geiger, Gu, Guly  s, H. Doheny, H. Faulkner, H. Monyer, He, Hestrin, Jonas, Karbowski, Kondo, Lambolez, Leranth, M. A. Whittington, Mahanty, Martina, Miles, Mosbacher, Mountford, Murakoshi, N. Kopell, Nagy, Petralia, R. D. Traub, Racca, Rozov, Singer, Sommer, Szab  , Traub, Traub, Traub, T  th, Vissavajjhala, Whittington, Whittington   +51 more
core   +3 more sources

Gain-of-function and loss-of-function GABRB3 variants lead to distinct clinical phenotypes in patients with developmental and epileptic encephalopathies

Nature Communications, 2022
Genetic variants of γ-aminobutyric acid (GABAA) receptors are associated with early onset epilepsies. Here, the authors show that functional loss or gain-of-function defines clinical outcomes, with gain-of-function variants unexpectedly more severe.
Nathan L. Absalom, Vivian W. Y. Liao, Katrine M. H. Johannesen, Elena Gardella, Julia Jacobs, Gaetan Lesca, Zeynep Gokce-Samar, Alexis Arzimanoglou, Shimriet Zeidler, Pasquale Striano, Pierre Meyer, Ira Benkel-Herrenbrueck, Inger-Lise Mero, Jutta Rummel, Mary Chebib, Rikke S. Møller, Philip K. Ahring   +16 more
doaj   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Towards translational neuroscience [PDF]

, 2015
Professor Robert Harvey has devoted his research career to studying the molecular neurobiology of inhibitory neurotransmission mediated by glycine and γ-aminobutyric acid.
Harvey, R
core  

High γ-aminobutyric acid production from lactic acid bacteria: emphasis on Lactobacillus brevis as a functional dairy starter [PDF]

, 2017
γ-Aminobutyric acid (GABA) and GABA-rich foods have shown anti-hypertensive and anti-depressant activities as the major functions in humans and animals.
Shah, N, Wu, Q
core   +1 more source

Synthetic amino acid-analogs of γ-aminobutyric acid

Bulletin of the Chemical Society of Ethiopia, 1989
Bull. Chem. Soc. Ethiop., 2(2) 57-60 (1989).
I.M. Ejimadu
doaj