Results 101 to 110 of about 1,574,238 (214)

Specific down-regulation of spinal μ-opioid receptor and reduced analgesic effects of morphine in mice with postherpetic pain [PDF]

application/pdfThe analgesic effects of opioid agonists and the expression of μ-and κ-opioid receptors were compared between mice with herpetic pain and those with postherpetic pain induced by herpetic virus inoculation.
9000006577975, 158169, Kuraishi, Yasushi, Shiraki, Kimiyasu, 9523, 00397176, 6029, Takasaki, Ichiro, Nojima, Hiroshi, 158167, 1000050135745, 50135745   +11 more
core   +1 more source

Chronic Heroin Self-Administration Desensitizes μ Opioid Receptor-Activated G-Proteins in Specific Regions of Rat Brain

, 2000
In previous studies from our laboratory, chronic noncontingent morphine administration decreased μ opioid receptor-activated G-proteins in specific brainstem nuclei.
Dana E. Selley, Steven R. Childers, Laura J. Sim-Selley, Leslie J. Vogt, Thomas J. Martin   +4 more
core   +1 more source

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source

The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors

, 2016
Coexpressed and colocalized μ- and δ-opioid receptors have been established to exist as heteromers in cultured cells and in vivo. However the biological significance of opioid receptor heteromer activation is less clear. To explore this significance, the
Matthew D. Metcalf (2063386), George L. Wilcox (2063380), Philip S. Portoghese (1330458), Michael D. Powers (1330446), Kelley F. Kitto (485517), Ajay S. Yekkirala (1933642), Carolyn A. Fairbanks (2063383)   +6 more
core   +1 more source

Contributions of Positive Social Interactions to Vocal Learning and Social Cohesion

Ethology, EarlyView.
Birdsong produced in non‐breeding flocks is shaped by a dynamic interplay between intrinsic reward and social feedback. Studies in cowbirds and starlings suggest that positive affective states and opioid‐mediated reward promote song practice, while responses from flock mates, potentially reinforced by dopaminergic mechanisms, refine species‐typical ...
Lauren V. Riters, Alyse N. Maksimoski
wiley   +1 more source

Specific staining of μ-opioid receptors in HEK 293 cells.

, 2013
Representative immunofluorescence images showing that the μ-receptor antibody only stains HEK 293 cells transfected with the mouse μ-opioid receptors, but not HEK 293 cells transfected with the mouse δ-opioid receptors coupled to eGFP, or in ...
Yvonne Schmidt (488909), Claire Gavériaux-Ruff (264483), Halina Machelska (488910)   +2 more
core   +1 more source

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis

International Journal of Dermatology, EarlyView.
Chronic prurigo, including prurigo nodularis, is a chronic, often treatment‐refractory condition characterized by persistent pruritus and chronic scratch lesions. Advances in the understanding of its underlying pathophysiology have enabled the development of novel targeted therapies; however, management remains challenging due to the expanding range of
Simon M. Mueller, Helmut Beltraminelli, Wolf‐Henning Boehncke, Maximilian Böhm, Antonio Cozzio, Peter Häusermann, Ahmad Jalili, Antonios G. A. Kolios, Claudia Lang, Eva Loos, Christoph Schlapbach, Curdin Conrad   +11 more
wiley   +1 more source

New 2‘,6‘-Dimethyl-l-tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique μ-Opioid Receptor Ligands

, 2016
The Aba-Gly scaffold, incorporated into Dmt-Tic ligands (H-Dmt-Tic-Gly-NH-CH2-Ph, H-Dmt-Tic-Gly-NH-Ph, H-Dmt-Tic-NH-CH2-Bid), exhibited mixed μ/δ or δ opioid receptor activities with μ agonism.
Lawrence H. Lazarus (2350999), Dirk Tourwé (2441938), Steven Ballet (654557), Yunden Jinsmaa (1936186), Gianfranco Balboni (402451), Severo Salvadori (402452), Sharon D. Bryant (2488435), Lucia Negri (843184), Claudio Trapella (1372722), Roberta Lattanzi (843185), Elisa Giannini (2403829)   +10 more
core   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Can Buprenorphine Be Overdosed? The Ceiling Effect and Its Clinical Implications

Pharmaceuticals
Opioids comprise a class of substances characterized by a narrow therapeutic window and significant euphoric effects. Opioid-related mortality remains a critical global health issue, primarily resulting from respiratory depression associated with full μ ...
Rozalia Beata Kozińska, Julia Ślęzak, Ignacy Ilski, Maja Podsiadła, Kamil Biedka, Emilia Królewicz   +5 more
doaj   +1 more source