Results 121 to 130 of about 1,574,238 (214)

Dihydroetorphine is a μ-Receptor-selective Ligand

, 1995
The selectivity to opioid receptors of dihydroetorphine, a potent analgesic with only mild physical dependence, was investigated using radioligand binding assay and its analgesic activity in mice determined.
Bo-Yi Qin, Xin-Qiang Lu, Dan-Xin Wang
core   +1 more source

The role of group III/IV afferent feedback in the ventilatory, pressor and metabolic responses to exercise in normoxia and hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Participants completed cycling exercise with (placebo) and without (25 µg intrathecal fentanyl) intact group III/IV muscle afferent feedback in three settings: normoxia, acute hypoxia and chronic hypoxia after 7–9 days of acclimatisation (∼3800 m). Blocking afferent feedback suppressed exercise hyperpnoea across all environments,
Elliott J. Jenkins, Phuong L. Ha, Connor A. Howe, Jay M. J. R. Carr, Justin A. Monteleone, Andrew J. M. Douglas, Abigail Nicholson, Andrew Steele, Brydie Lemkes, Jodie L. Koep, L. Madden Brewster, Jennifer Duffy, Mathew I. B. Debenham, Tena Monaghan, Declan Isaak, Jacob McCormick, Brian H. Dalton, Chris J. McNeil, Jared Baylis, David MacLeod, Mike Stembridge, Markus Amann, Philip N. Ainslie, Travis D. Gibbons   +23 more
wiley   +1 more source

A Study of the Kratom Alkaloids and Their Binding to the μ-Opioid Receptor [PDF]

, 2019
Kratom, a plant commonly found in southeast Asia, has traditionally been used for medicinal treatments. Recently, however, the popularity of the drug has significantly increased due to its euphoric effects, leading to it being used as an alternative to ...
Chamblee, Reba Elizabeth Ann
core   +2 more sources

Subtype-selective binding of milk β-casomorphins across the opioid receptor family revealed by molecular docking and molecular dynamics simulation

Journal of Dairy Science
: β-Casomorphins (BCM) are opioid-like peptides produced during the digestion of β-casein in the gastrointestinal tract. They are also involved in other gastrointestinal and neurophysiological processes.
Tae-Hong Min, Min-Jae Jang, Arvind Kumar Yadav, Chiwoong Lim, Rajesh Kumar Pathak, Jun-Mo Kim   +5 more
doaj   +1 more source

The Effect of Opioid Abatement Funds on the Utilization of Medications for Opioid Use Disorder

Health Services Research, Volume 61, Issue 6, December 2026.
ABSTRACT Objective To evaluate whether opioid abatement fund allocations to treatment programs influence the utilization of medications for opioid use disorder (MOUD). Study Setting and Design The study employed a synthetic difference‐in‐differences design and a triple‐differences model using a state‐year panel to estimate the effects of abatement fund
Jiajing Scarlette Shi, Hefei Wen
wiley   +1 more source

Systematic profiling reveals broad G protein coupling and context‐dependent modulation of cyclic AMP by the orphan receptor GPR139

British Journal of Pharmacology, Volume 183, Issue 23, Page 6865-6882, December 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are major drug targets, yet many orphan receptors remain poorly characterized. GPR139 has been implicated in CNS disorders, including schizophrenia and depression, but its signalling mechanisms remain unclear.
Boris Trapkov, Hans Bräuner, Alexander Sebastian Hauser   +2 more
wiley   +1 more source

Complexity of Clathrin Coat Dynamics in Endocytosis

Traffic, Volume 27, Issue 4, December 2026.
Clathrin dynamics during endocytosis. Dynamic exchange of clathrin triskelia and other endocytic proteins may be critical for several processes taking place during the maturation of endocytic vesicles. ABSTRACT Clathrin‐mediated endocytosis is a process by which eukaryotic cells internalise a wide range of molecules such as signalling factors ...
Anne‐Laure Boinet, Aurélien Roux, Marko Kaksonen   +2 more
wiley   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, Volume 143, Issue 41, November 5, 2026.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

Annals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl, We Fong Siah, Jasmin Lope, Jennifer C. Hengeveld, Mark A. Doherty, Russell L. McLaughlin, Orla Hardiman, Ee Ling Tan, Alison Toomey, Jana Kleinerova, Peter Bede   +10 more
wiley   +1 more source

Brain region–specific neural activation by low-dose opioid promotes social behavior

JCI Insight
The opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear.
Soichiro Ohnami, Megumi Naito, Haruki Kawase, Momoko Higuchi, Shigeru Hasebe, Keiko Takasu, Ryo Kanemaru, Yuki Azuma, Rei Yokoyama, Takahiro Kochi, Eiji Imado, Takeru Tahara, Yaichiro Kotake, Satoshi Asano, Naoya Oishi, Kazuhiro Takuma, Hitoshi Hashimoto, Koichi Ogawa, Atsushi Nakamura, Hidekuni Yamakawa, Yukio Ago   +20 more
doaj   +1 more source