Results 131 to 140 of about 1,574,238 (214)

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3914-3925, November 2026.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1250-1254, November 2026.
New Approach Methodologies (NAMs) represent a paradigm shift in drug development and regulatory science, offering human‐relevant alternatives to traditional preclinical models. This mini‐review highlights recent advances in NAM development, validation, and regulatory application from FDA's Division of Applied Regulatory Science (DARS).
Ksenia Blinova, Kimberly Chiu, Anik Chaturbedi, Jahan Cooper, Tromondae K. Feaster, Paula L. Hyland, Lidiya Stavitskaya, Wendy W. Wu, Jeffry Florian, Rodney Rouse   +9 more
wiley   +1 more source

Detection of Nitazenes in the Illicit Drug Supply Utilizing Precursor Ion Scan Methods With Paper Spray Mass Spectrometry

Drug Testing and Analysis, Volume 18, Issue 11, Page 1386-1396, November 2026.
Nitazenes are increasingly present in the illicit drug supply, complicating harm reduction efforts. We have developed a rapid, nontargeted precursor ion scan method to detect emerging nitazenes in real‐world opioid samples. The method identified multiple nitazenes, often replacing pharmaceutical opioids or mixed with fentanyl and benzodiazepines ...
Allie Miskulin, Irene Shkolnikov, Jindar Sboto, Collin Kielty, Bruce Wallace, Chris G. Gill, Dennis K. Hore   +6 more
wiley   +1 more source

Opioid Receptors Gene Polymorphism and Heroin Dependence in Iran

Basic and Clinical Neuroscience, 2018
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence.
Sara Soleimani Asl, Amir Roointan, Hugo Bergen, Shayan Amiri, Parastoo Mardani, Niloufar Ashtari, Ronak Shabani, Mehdi Mehdizadeh   +7 more
doaj  

Prescription Intervals of Medications for Chronic Use: A Cohort Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 11, November 2026.
ABSTRACT Purpose In deprescribing studies, a prescription‐free gap is typically used to determine if patients discontinued their treatment. An appropriate gap depends on the typical time between prescriptions during continued use. This work aims to characterise the interval between prescriptions of chronic drugs (long‐term use) using different methods ...
Ryan Muddiman, Padraic Donoghue, Jessica Gómez Lemus, Ann Sinéad Doherty, Fiona Boland, Caroline McCarthy, Frank Moriarty   +6 more
wiley   +1 more source

Molecular mechanism of allosteric modulation of opioid receptors

Signal Transduction and Targeted Therapy
Opioid analgesics provide potent pain relief but are limited by severe adverse effects, tolerance, and interindividual genetic variability in response. Poly-pharmacology and allosteric modulation of opioid receptors offer promising strategies to enhance ...
Heli Wang, Zhuang Miao, Chang Zhao, Hong Fu, Xiaowen Tian, Xinlei Liu, Lei Wang, Yuan Liu, Xingyu Liu, Xihao Yong, Lantian Su, Wei Yan, Lin Cheng, Renjie Chai, Zhenhua Shao, Bowen Ke   +15 more
doaj   +1 more source

Impact of opioid use disorder on oxytocin required for labor induction in term pregnancies

Pregnancy, Volume 2, Issue 6, November 2026.
Abstract Objective Oxytocin is a neuropeptide proven to impact human labor, lactation, and social affinity and is of interest in the study of pain and μ‐opioid receptor modulation. Individuals impacted by opioid use disorder (OUD) frequently have μ‐opioid receptor dysregulation.
Hansika Kunduru, Judy Jiang, Hannah Hill, Jessica Wilder   +3 more
wiley   +1 more source

Individual Differences in Sleep Quality: Exploring the Impact of Temperament on Sleep Through Anxiety and Depression

Personality and Mental Health, Volume 20, Issue 4, November 2026.
ABSTRACT According to the functional ensemble of temperament (FET) model, individual differences in temperament arise from the balance of neurotransmitter systems also crucial for regulating circadian rhythms and sleep, suggesting a strong neurobiological link between temperament and sleep behavior.
Stefano Lasaponara, Angelica Scuderi, Elisa Pellegrini, Ludovica Annarumma, Valentina Piga, Sara Lo Presti, Maurizio Gorgoni   +6 more
wiley   +1 more source

The wider network of social relationships and desistance from crime

Criminology, Volume 64, Issue 4, Page 1116-1148, November 2026.
Abstract Prior research has focused on marriage as a key relationship associated with crime cessation. Yet particularly within the contemporary context, relationships with parents, peers, and other family members may also foster or inhibit progress toward desistance.
Peggy C. Giordano, Jennifer E. Copp, Megan Swinehart, Wendy D. Manning, Monica A. Longmore   +4 more
wiley   +1 more source

Craving and personal functioning as mediators of extended‐release buprenorphine efficacy: A four‐way decomposition analysis from a randomised trial

Addiction, Volume 121, Issue 11, Page 3010-3024, November 2026.
Abstract Aims To investigate whether the treatment effect of extended‐release buprenorphine (BUP‐XR) on opioid‐free days in opioid use disorder (OUD) is mediated by reductions in opioid craving and improvements in personal functioning. Design and setting Exploratory causal mediation analysis using VanderWeele's four‐way decomposition framework in a 24 ...
John Marsden, Mike Kelleher, Fiona Cowden, Edward Day, Jonathan Dewhurst, Rachel Evans, Eilish Gilvarry, Natalie Lowry, Luke Mitcheson, Robert Murray, Sophie Quarshie, Zoë Hoare   +11 more
wiley   +1 more source