Results 151 to 160 of about 1,574,238 (214)

Scanning Site Saturation Mutagenesis of the Human μ-Opioid Receptor [PDF]

The human μ-opioid receptor (μOR) mediates the therapeutic and adverse effects of opioids, yet its structural determinants of function remain poorly understood. This study employed Scanning Site Saturation Mutagenesis (SSSM) to systematically analyze the
Vilkhu, Manpreet
core  

Non-equilibrium snapshots of ligand efficacy at the μ-opioid receptor. [PDF]

Nature
Robertson MJ, Modak A, Papasergi-Scott MM, Hu M, Peroto MC, Varga BR, Majumdar S, Kalathur R, Blanchard SC, Skiniotis G.   +9 more
europepmc   +1 more source

Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation. [PDF]

Biomol Ther (Seoul)
Huang L, Wang M, Kundu D, Paudel S, Peng L, Xian X, Jang CG, Kim KM.   +7 more
europepmc   +1 more source

Mitragynine and Morphine Stabilize Different Conformations of the μ‑Opioid Receptor as Revealed by Molecular Dynamics Simulation Studies. [PDF]

ACS Omega
Neupane NP, Mathews JT, Lingaraju S, You Y, Mathukumalli K, Das J.   +5 more
europepmc   +1 more source

Efficient and specific selection of high-affinity DNA aptamers targeting μ-opioid receptor via functional extracellular vesicles. [PDF]

Commun Biol
Ikemoto MJ, Kamikubo Y, Uta D, Kirinoki K, Kiriyama M, Miyajima T, Sakairi H, Kano M, Sakurai T, Tabata T.   +9 more
europepmc   +1 more source

The molecular basis of μ-opioid receptor signaling plasticity. [PDF]

Cell Res
Zhang H, Wang X, Xi K, Shen Q, Xue J, Zhu Y, Zang SK, Yu T, Shen DD, Guo J, Chen LN, Ji SY, Qin J, Dong Y, Zhao M, Yang M, Wu H, Yang G, Zhang Y.   +18 more
europepmc   +1 more source

Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor. [PDF]

J Org Chem
Gregorc J, De Neve J, Guitot K, Holleran BJ, Lensen N, Gendron L, Brigaud T, Iskra J, Ballet S, Chaume G.   +9 more
europepmc   +1 more source

Structural snapshots capture nucleotide release at the μ-opioid receptor. [PDF]

Nature
Khan S, Tyson AS, Ranjbar M, Zhang Z, Singh J, Han GW, Gati C.   +6 more
europepmc   +1 more source

Emotion processing in schizophrenia and its relation to μ-opioid receptor availability. [PDF]

Neuroimage Clin
Shatalina E, Ashok AH, Wall MB, Myers J, Marques TR, Rabiner EA, Howes OD.   +6 more
europepmc   +1 more source

μ-Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks. [PDF]

Ann Neurol
Kim DJ, Lim M, Nascimento TD, Porreca F, Koeppe RA, Hadjikhani N, DaSilva AF.   +6 more
europepmc   +1 more source