Results 21 to 30 of about 1,574,238 (214)

Recent Molecular Insights into Agonist-specific Binding to the Mu-Opioid Receptor

Frontiers in Molecular Biosciences, 2022
Opioid agonists produce their analgesic effects primarily by acting at the µ-opioid receptor (µOR). µOR agonists with different efficacies exert diverse molecular changes in the µOR which dictate the faith of the receptor’s signaling pathway and possibly
Ferenc Zádor, Kornél Király, Nariman Essmat, Mahmoud Al-Khrasani   +3 more
doaj   +1 more source

Methamphetamine-induced changes in the striatal dopamine pathway in μ-opioid receptor knockout mice

Journal of Biomedical Science, 2011
Background Repeated exposure to methamphetamine (METH) can cause not only neurotoxicity but also addiction. Behavioral sensitization is widely used as an animal model for the study of drug addiction.
Park Sang Won, Shen Xine, Tien Lu-Tai, Roman Richard, Ma Tangeng   +4 more
doaj   +1 more source

How μ-opioid receptor recognizes fentanyl

Nature Communications, 2021
Structures of mu-opioid receptor (mOR) in complex with morphine derivatives have been determined; but the structural basis of mOR activation by fentanyl-like synthetic opioids remains unclear.
Quynh N. Vo, Paween Mahinthichaichan, Jana Shen, Christopher R. Ellis   +3 more
doaj   +1 more source

Impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain

Molecular Pain, 2016
Objective To investigate the impacts of anti-nerve growth factor antibody on pain-related behaviors and expressions of μ-opioid receptor in spinal dorsal horn and dorsal root ganglia of rats with cancer-induced bone pain.
Peng Yao MD, PhD, Yuanyuan Ding MD, Zhibin Wang MD, Jiaming Ma MM, Tao Hong MM, Yongqiang Zhu MM, Hongxi Li MM, Shinong Pan MD, PhD   +7 more
doaj   +1 more source

Decrease of morphine-CPP by sinomenine via mediation of tyrosine hydroxylase, NMDA receptor subunit 2B and opioid receptor in the zebrafish brain

Pakistan Journal of Pharmaceutical Sciences, 2021
To study the effects of sinomenine on conditioned place preference (CPP) zebrafish induced by morphine and expression levels of intracephalic tyrosine hydroxylase (TH), NMDA receptor subunit 2B (NR2B), μ-opioid receptor (zfmor) and δ-opioid receptors ...
Yingbo Lin, Hancheng Li, Ju Peng, Chan Li, Chen Zhu, Yuting Zhou, Zhijie Chen, Jing Li, Chaohua Luo, Zhixian Mo   +9 more
doaj   +1 more source

Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis

Frontiers in Medicine, 2022
BackgroundMyoclonic movement is a very common but undesirable phenomenon during the induction of general anesthesia using etomidate. Such movement may cause unnecessary problems.
Kang-Da Zhang, Lin-Yu Wang, Dan-Xu Zhang, Zhi-Hua Zhang, Huan-Liang Wang, Huan-Liang Wang   +5 more
doaj   +1 more source

Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats

Dose-Response, 2019
Backgrounds: This study compared analgesic effects and μ-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat.
Wei Liu, Heqi Liu, Zongde Zhang, Jiapeng Huang   +3 more
doaj   +1 more source

Potential use of early alterations in μ and δ opioid receptors as a predictive index for delayed brain ischemic damage

Neurobiology of Disease, 2003
We previously reported differential alterations of the μ, δ, and κ opioid receptors following permanent middle cerebral artery occlusion. The present work studied the evolution of opioid receptor types following transient focal cerebral ischemia (tMCAO),
Hervé Boutin, Philippe Jauzac, Eric T. MacKenzie, François Dauphin   +3 more
doaj   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

μ-Opioid receptor-knockout mice: the role of μ-opioid receptor in gastrointestinal transit

, 1998
The role of μ-opioid receptor in gastrointestinal transit was investigated using μ-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a μ-opioid receptor mediated function.
Roy, Sabita, Loh, Horace H, Liu, Hsien-Ching, Hsien-Ching Liu, Sabita Roy, Horace H Loh   +5 more
core   +1 more source