Results 41 to 50 of about 1,574,238 (214)
Journal of Pharmacological Sciences, 2009 .: In this study, we compared the effects of five short-, medium-, or long-acting benzodiazepine-receptor agonists (BZDs) [alprazolam (APZ), clonazepam (CLZ), flunitrazepam (FLZ), loprazolam (LPZ), zolpidem (ZLP)], at two distinct doses, 0.2 and 2 mg/kg,
Géraldine Poisnel +4 more
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, 2003 Beta-arrestins have been suggested to regulate μ-, δ-, and κ-opioid receptor-mediated responses. In the present study, we examined the effects of pretreatment with β-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the ...
Mizoguchi, Hirokazu +5 more
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Research progress on biased μ-opioid receptor agonists
徐州医科大学学报Opioid analgesics, which primarily exert their effects through μ-opioid receptors, have long been valuable choices in pain management. However, opioid analgesics often cause various adverse reactions that are common to traditional opioids, especially ...
LI Ning, LIU Cunming
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Neurobiology of Disease, 1996 The μ opioid receptor plays a key role in mediating the physiological, pharmacological, and behavioral effects of endogenous opioids and of opiate drugs such as morphine and heroin.
Brendon Watson, Fan Meng, Huda Akil
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, 2016 To better understand structural requirements for a μ ligand of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class to interact with the μ opioid receptor, we have described in the previous article (Le Bourdonnec, B. et al. J. Med. Chem.
Roland E. Dolle (1484149) +6 more
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Receptor Studies in Opioid Receptor and Opioid Peptide Gene Knockout Mice. [PDF]
, 2020 1. It is postulated that dynorphin inhibits the cocaine-induced increase in striatal dopamine levels, that may contribute to dynorphin’s ability to prevent cocaine-induced conditioned place preference and to attenuate an increase in locomotor activity ...
Yoo, Ji Hoon.
core
μ-opioid receptor system mediates reward processing in humans
Nature Communications, 2018 μ-opioid signalling has a known role in the response to various rewarding stimuli, including pleasant foods. Here, Nummenmaa et al. show using PET and fMRI that individual differences in brain μ-opioid receptor density predict the strength of the neural ...
Lauri Nummenmaa +6 more
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MU-opioid receptor-knockout mice: role of μ-opioid receptor in morphine mediated immune functions
, 1998 The role of the μ-opioid receptor in immune function was investigated using μ-opioid receptor knockout mice (MOR-KO). Morphine modulation of several immune functions, including macrophage phagocytosis and macrophage secretion of TNF-α, was not observed ...
Barke, Roderick A +5 more
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British Journal of Clinical Pharmacology, EarlyView.Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen +17 more
wiley +1 more source
Endogenous opioids regulate moment-to-moment neuronal communication and excitability
Nature Communications, 2017 The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid ...
Bryony L. Winters +9 more
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