Results 81 to 90 of about 109,939 (248)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Corrosion Resistance of Solution-Treated S32750 Duplex Stainless Steel in a Simulated Flue Gas Desulfurization Environment [PDF]

open access: yesCailiao Baohu
The metallurgical structure changes of S32750 duplex stainless steel during solution treatment can reduce its corrosion resistance in flue gas desulfurization environments.In this study,S32750 duplex stainless steel was solution-treated at temperatures ...
XIA Qingliang
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Formation energy in \sigma-phase Fe-V alloys

open access: yes, 2012
Formation energy of the \sigma-phase in the Fe-V alloy system, \Delta E, was computed in the full compositional range of its occurrence (34 < x < 60) using the electronic band structure calculations by means of the KKR method.
Cieslak, J., Dubiel, S. M., Tobola, J.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Stable Frank-Kasper phases of self-assembled, soft matter spheres

open access: yes, 2018
Single molecular species can self-assemble into Frank Kasper (FK) phases, finite approximants of dodecagonal quasicrystals, defying intuitive notions that thermodynamic ground states are maximally symmetric.
Arora, Akash   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Effect of Cr and Mo on σ- Phase Precipitation Behavior and Pitting Corrosion Resistance Properties of Ultra-Low-Carbon Dual Phase Stainless Steel

open access: yesTeshugang, 2015
The σ-phase precipitation rule in four kinds of typical ultra-low-carbon dual phase stainless steel 00Cr21Ni2Mn5N, 00Cr22Ni5Mo3N, 00Cr25Ni7Mo3N and 00Cr27Ni7Mo5N solid-solution-treaded at 1 050 ~ 1 120 °C and aged at 500 ~ 1 100 °C and the effect of σ ...
李惠   +4 more
doaj  

Phase space monitoring of exciton-polariton multistability

open access: yes, 2014
Dynamics of exciton-polariton multistability is theoretically investigated. Phase portraits are used as a tool to enlighten the microscopic phenomena which influence spin multistability of a confined polariton field as well as ultrafast reversible spin ...
Léger, Yoan
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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