Results 61 to 70 of about 109,939 (248)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Controlled self-assembly of periodic and aperiodic cluster crystals [PDF]

, 2014
Soft particles are known to overlap and form stable clusters that self-assemble into periodic crystalline phases with density-independent lattice constants.
Barkan, Kobi, Engel, Michael, Lifshitz, Ron   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Phenomenological theory of a scalar electronic order: application to skutterudite PrFe4P12

, 2008
By phenomenological Landau analysis, it is shown that a scalar order parameter with the point-group symmetry $\Gamma_{1g}$ explains most properties associated with the phase transition in PrFe$_4$P$_{12}$ at 6.5 K.
Aoki Y., de Visser A., Hao L., Hao L., Hidaka H., Iwasa K., Kawana D., Kikuchi J., Kikuchi J., Kiss A., Matsuda T. D., McElfresh M. W., Nakanishi Y., Nakanishi Y., Namiki T., Saha S. R., Sakai O., Sato H., Tayama T.   +18 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Effect of Mn on σ Phase and Toughness of 22%Cr Duplex Stainless Steel by Aging Treatment at 700℃

Cailiao gongcheng, 2017
The effect of different Mn contents on the σ phase and toughness of 22%Cr (mass fraction, the same below) low-nickel DSS by means of OM, XRD, SEM, TEM, precipitation kinetics and Charpy impact tests was studied.
BAI Yu-liang, YANG Yin-hui, CAO Jian-chun, GU Yang, PU Jing   +4 more
doaj   +1 more source

Short-Range Order in Fe-Rich Fe-Cr Alloys as Revealed by M\"ossbauer Spectroscopy

, 2011
Distribution of Cr atoms in Fe_{100-x}Cr_x alloys with x \le 25 within the first two coordination shells, 1NN-2NN, around probe 57Fe atoms was studied by means of the M\"ossbauer Spectroscopy.
J. Cieslak, N. P. Filippova, S. M. Dubiel   +2 more
core   +1 more source

Gouy-Stodola Theorem as a variational principle for open systems [PDF]

, 2012
The recent researches in non equilibrium and far from equilibrium systems have been proved to be useful for their applications in different disciplines and many subjects.
Lucia, Umberto
core   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

σ-phase precipitation in weld metal of austenitic stainless steels and its effect on properties

Hanjie xuebao
Low-temperature conditions necessitate high toughness in the welded joints of austenitic stainless steel structures. However, the impact toughness of the weld metal decreases significantly when using electrodes developed for SMAW under such conditions ...
Xuegang ZHANG, Xuchao GUO, Shuaijie JIAO, Meng WANG, Yan CHEN, Tingting SUN, Pengliang HU   +6 more
doaj   +1 more source