Results 41 to 50 of about 110,583 (215)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

In-situ study of σ phase evolution in 25Cr-7Ni duplex stainless steel (DSS): Unrevealing critical insight

Materials & Design
The current understanding of the formation mechanism and kinetics of the σ phase in DSS remains ambiguous. This study investigates the in-situ evolution of the σ phase in DSS through a multi-faceted approach.
Raj Narayan Hajra, Byoung Jun Han, Jin Woong Park, Woo Hyeok Kim, Joonho Lee, Won-Seok Ko, Jeoung Han Kim   +6 more
doaj   +1 more source

Precipitation law of σ phase in 2205 duplex stainless steel

工程科学学报, 2015
After solution treatment at 1300℃ and cold rolling deformation at different reductions, 2205 duplex stainless steel was homogenized at different temperatures for different time intervals.
LI Shu-xia, REN Xue-ping, TONG Jian-guo, HOU Hong-liang   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

σ-phase precipitation in weld metal of austenitic stainless steels and its effect on properties

Hanjie xuebao
Low-temperature conditions necessitate high toughness in the welded joints of austenitic stainless steel structures. However, the impact toughness of the weld metal decreases significantly when using electrodes developed for SMAW under such conditions ...
Xuegang ZHANG, Xuchao GUO, Shuaijie JIAO, Meng WANG, Yan CHEN, Tingting SUN, Pengliang HU   +6 more
doaj   +1 more source

Effect of Mn on σ Phase and Toughness of 22%Cr Duplex Stainless Steel by Aging Treatment at 700℃

Cailiao gongcheng, 2017
The effect of different Mn contents on the σ phase and toughness of 22%Cr (mass fraction, the same below) low-nickel DSS by means of OM, XRD, SEM, TEM, precipitation kinetics and Charpy impact tests was studied.
BAI Yu-liang, YANG Yin-hui, CAO Jian-chun, GU Yang, PU Jing   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Σ-Δ modulation analysis and optimization in fractional-N frequency synthesizer

Dianzi Jishu Yingyong, 2018
Analyzed the impaction of Σ-Δ modulation on Σ-Δ frequency synthesizer′s phase noise and spurs, and optimized Σ-Δ modulator to improve the performance of Σ-Δ frequency synthesizer.
Yang Jianming
doaj   +1 more source