Results 61 to 70 of about 9,489,591 (252)

Influence of σ Phase on the Allotropic Transformation of the Matrix in Co-Re-Cr-Based Alloys with Ni Addition

Metals, 2018
Co-Re-Cr alloys are being developed for high-temperature application in gas turbines. In these alloys, the Cr2Re3-based σ phase is stable when the Cr content is higher than 20 atomic %. The addition of Ni is being studied to partially substitute Cr,
Kai Dörries, Debashis Mukherji, Joachim Rösler, Katharina Esleben, Bronislava Gorr, Hans-Juergen Christ   +5 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Creep-coordinated behaviors of the σ phase with stacking disordering defects in a Ni-based single crystal superalloy

Materials & Design
Ni-based single crystal superalloys (Ni-SXs) generally precipitate unfavorable topologically close-packed (TCP) phases at elevated temperatures. Conventional design strategies primarily aim to suppress TCP phase formation; however, this approach often ...
Tianyu Zhang, Wenwen Wang, Wenqi Guo, Haigen Zhao, Xiaoxiang Wu, Changkui Yu, Yuanhang Gao, Mi Zhang, Zijin Liu, Yanling Pei, Shusuo Li, Shengkai Gong   +11 more
doaj   +1 more source

Spectral phase conjugation with cross-phase modulation compensation [PDF]

, 2004
Spectral phase conjugation with short pump pulses in a third-order nonlinear material is analyzed in depth. It is shown that if signal amplification is considered, the conversion efficiency can be significantly higher than previously considered, while ...
Psaltis, Demetri, Tsang, Mankei
core  

Transition to Chaotic Phase Synchronization through Random Phase Jumps

, 1999
Phase synchronization is shown to occur between opposite cells of a ring consisting of chaotic Lorenz oscillators coupled unidirectionally through driving.
D. PAZÓ, Güémez J., I. P. MARIÑO, Osipov G. V., Parlitz U., Pikovsky A., V. PÉREZ-MUÑUZURI, V. PÉREZ-VILLAR   +7 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Effect of Yttrium Addition on the Solidification Microstructure and Sigma Phase Precipitation Behavior of S32654 Super Austenitic Stainless Steel

Metals
This study focuses on S32654 super austenitic stainless steel (SASS) and systematically characterizes the morphology of the sigma (σ) phase and the segregation behavior of alloying elements in its as-cast microstructure.
Jun Xiao, Geng Tian, Di Wang, Shaoguang Yang, Kuo Cao, Jianhua Wei, Aimin Zhao   +6 more
doaj   +1 more source

Study on σ Phase in Fe–Al–Cr Alloys

Metals, 2019
In this paper, a method of using the second phase to control the grain growth in Fe−Al−Cr alloys was proposed, in order to obtain better mechanical properties.
Jintao Wang, Shouping Liu, Xiaoyu Han
doaj   +1 more source