Results 51 to 60 of about 109,697 (226)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Creep-coordinated behaviors of the σ phase with stacking disordering defects in a Ni-based single crystal superalloy

Materials & Design
Ni-based single crystal superalloys (Ni-SXs) generally precipitate unfavorable topologically close-packed (TCP) phases at elevated temperatures. Conventional design strategies primarily aim to suppress TCP phase formation; however, this approach often ...
Tianyu Zhang, Wenwen Wang, Wenqi Guo, Haigen Zhao, Xiaoxiang Wu, Changkui Yu, Yuanhang Gao, Mi Zhang, Zijin Liu, Yanling Pei, Shusuo Li, Shengkai Gong   +11 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Effect of Yttrium Addition on the Solidification Microstructure and Sigma Phase Precipitation Behavior of S32654 Super Austenitic Stainless Steel

Metals
This study focuses on S32654 super austenitic stainless steel (SASS) and systematically characterizes the morphology of the sigma (σ) phase and the segregation behavior of alloying elements in its as-cast microstructure.
Jun Xiao, Geng Tian, Di Wang, Shaoguang Yang, Kuo Cao, Jianhua Wei, Aimin Zhao   +6 more
doaj   +1 more source

Measurement of the CP-violating weak phase ϕ s and the decay width difference ΔΓ s using the Bs0→J/ψϕ(1020) decay channel in pp collisions at s=8 TeV

Physics Letters B, 2016
The CP-violating weak phase ϕs of the Bs0 meson and the decay width difference ΔΓs of the Bs0 light and heavy mass eigenstates are measured with the CMS detector at the LHC using a data sample of Bs0→J/ψϕ(1020)→μ+μ−K+K− decays. The analysed data set corresponds to an integrated luminosity of 19.7fb−1 collected in pp collisions at a ...
Khachatryan, V., Sirunyan, A.M., Tumasyan, A., Adam, W., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Erö, J., Flechl, M., Friedl, M., Frühwirth, R., Ghete, V.M., Hartl, C., Hörmann, N., Hrubec, J., Jeitler, M., Knünz, V., König, A., Krammer, M., Krätschmer, I., Liko, D., Matsushita, T., Mikulec, I., Rabady, D., Rahbaran, B., Rohringer, H., Schieck, J., Schöfbeck, R., Strauss, J., Treberer-Treberspurg, W., Waltenberger, W., Wulz, C.E., Mossolov, V., Shumeiko, N., Suarez Gonzalez, J., Alderweireldt, S., Cornelis, T., De Wolf, E.A., Janssen, X., Knutsson, A., Lauwers, J., Luyckx, S., Ochesanu, S., Rougny, R., Van De Klundert, M., Van Haevermaet, H., Van Mechelen, P., Van Remortel, N., Van Spilbeeck, A., Abu Zeid, S., Blekman, F., D'Hondt, J., Daci, N., De Bruyn, I., Deroover, K., Heracleous, N., Keaveney, J., Lowette, S., Moreels, L., Olbrechts, A., Python, Q., Strom, D., Tavernier, S., Van Doninck, W., Van Mulders, P., Van Onsem, G.P., Van Parijs, I., Barria, P., Brun, H., Caillol, C., Clerbaux, B., De Lentdecker, G., Delannoy, H., Fasanella, G., Favart, L., Gay, A.P.R., Grebenyuk, A., Karapostoli, G., Lenzi, T., Léonard, A., Maerschalk, T., Marinov, A., Perniè, L., Randle-conde, A., Reis, T., Seva, T., Vander Velde, C., Vanlaer, P., Yonamine, R., Zenoni, F., Zhang, F., Beernaert, K., Benucci, L., Cimmino, A., Crucy, S., Dobur, D., Fagot, A., Garcia, G., Gul, M., Mccartin, J., Ocampo Rios, A.A., Poyraz, D., Ryckbosch, D., Salva, S., Sigamani, M., Strobbe, N., Tytgat, M., Van Driessche, W., Yazgan, E., Zaganidis, N., Basegmez, S., Beluffi, C., Bondu, O., Brochet, S., Bruno, G., Castello, R., Caudron, A., Ceard, L., Da Silveira, G.G., Delaere, C., Favart, D., Forthomme, L., Giammanco, A., Hollar, J., Jafari, A., Jez, P., Komm, M., Lemaitre, V., Mertens, A., Nuttens, C., Perrini, L., Pin, A., Piotrzkowski, K., Popov, A., Quertenmont, L., Selvaggi, M., Vidal Marono, M., Beliy, N., Hammad, G.H., Aldá Júnior, W.L., Alves, G.A., Brito, L., Correa Martins Junior, M., Hamer, M., Hensel, C., Mora Herrera, C., Moraes, A., Pol, M.E., Rebello Teles, P., Belchior Batista Das Chagas, E., Carvalho, W., Chinellato, J., Custódio, A., Da Costa, E.M., De Jesus Damiao, D., De Oliveira Martins, C., Fonseca De Souza, S., Huertas Guativa, L.M., Malbouisson, H., Matos Figueiredo, D., Mundim, L., Nogima, H., Prado Da Silva, W.L., Santoro, A., Sznajder, A., Tonelli Manganote, E.J., Vilela Pereira, A., Ahuja, S., Bernardes, C.A., De Souza Santos, A., Dogra, S., Fernandez Perez Tomei, T.R., Gregores, E.M., Mercadante, P.G., Moon, C.S., Novaes, S.F., Padula, Sandra S., Romero Abad, D., Ruiz Vargas, J.C., Aleksandrov, A., Hadjiiska, R., Iaydjiev, P., Rodozov, M., Stoykova, S., Sultanov, G., Vutova, M., Dimitrov, A., Glushkov, I., Litov, L., Pavlov, B., Petkov, P., Ahmad, M., Bian, J.G., Chen, G.M., Chen, H.S., Chen, M., Cheng, T., Du, R.   +199 more
openaire  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Study on σ Phase in Fe–Al–Cr Alloys

Metals, 2019
In this paper, a method of using the second phase to control the grain growth in Fe−Al−Cr alloys was proposed, in order to obtain better mechanical properties.
Jintao Wang, Shouping Liu, Xiaoyu Han
doaj   +1 more source

Holographic p-wave superconductivity from higher derivative theory

European Physical Journal C: Particles and Fields, 2021
We construct a holographic SU(2) p-wave superconductor model with Weyl corrections. The high derivative (HD) terms do not seem to spoil the generation of the p-wave superconducting phase. We mainly study the properties of AC conductivity, which is absent
Yan Liu, Guoyang Fu, Hai-Li Li, Jian-Pin Wu, Xin Zhang   +4 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source