Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution [PDF]
Biomolecules, 2015 Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP) that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis.
Mark S B Paget
exaly +5 more sources
A model for sigma factor competition in bacterial cells. [PDF]
PLoS Computational Biology, 2014 Sigma factors control global switches of the genetic expression program in bacteria. Different sigma factors compete for binding to a limited pool of RNA polymerase (RNAP) core enzymes, providing a mechanism for cross-talk between genes or gene classes ...
Marco Mauri, Stefan Klumpp
doaj +7 more sources
A novel extracytoplasmic function sigma factor (RpoE6) regulates biogenesis of a minor flagellin and other functions in Azospirillum brasilense Sp7 [PDF]
Journal of BacteriologyIn Gammaproteobacteria, the biogenesis of the flagellar filaments is regulated by a flagellum-specific sigma factor (FliA). In Alphaproteobacteria, however, a flagellum-specific sigma factor is not known.
Parikshit Gupta +7 more
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Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference [PDF]
mSphere, 2023 Chlamydia trachomatis is a developmentally regulated, obligate intracellular bacterium that encodes three sigma factors: σ66, σ54, and σ28. σ66 is the major sigma factor controlling most transcription initiation during early- and mid-cycle development as
Nathan D. Hatch, Scot P. Ouellette
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PLoS Computational Biology, 2016 Despite the central role of alternative sigma factors in bacterial stress response and virulence their regulation remains incompletely understood. Here we investigate one of the best-studied examples of alternative sigma factors: the σB network that ...
Jatin Narula +2 more
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New layers of regulation of the general stress response sigma factor RpoS [PDF]
Frontiers in MicrobiologyThe general stress response (GSR) sigma factor RpoS from Escherichia coli has emerged as one of the key paradigms for study of how numerous signal inputs are accepted at multiple levels into a single pathway for regulation of gene expression output ...
Simon Handler, Clare L. Kirkpatrick
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M. tuberculosis Ser/Thr protein kinase D phosphorylates an anti-anti-sigma factor homolog. [PDF]
PLoS Pathogens, 2007 Receptor Ser/Thr protein kinases are candidates for sensors that govern developmental changes and disease processes of Mycobacterium tuberculosis (Mtb), but the functions of these kinases are not established. Here, we show that Mtb protein kinase (Pkn) D
Andrew E Greenstein +5 more
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Involvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility in Stenotrophomonas maltophilia [PDF]
Frontiers in Cellular and Infection MicrobiologyBackgroundHemin is a major source of iron for pathogens in infectious niches. The FecIRA-like surface signaling cascade is a common regulatory system for iron acquisition by pathogens. This system consists of a FecA-like TonB-dependent transporter (TBDT),
Chun-Hsing Liao +7 more
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The Transposition of Insertion Sequences in Sigma-Factor- and LysR-Deficient Mutants of Deinococcus geothermalis [PDF]
MicroorganismsSome insertion sequence (IS) elements were actively transposed using oxidative stress conditions, including gamma irradiation and hydrogen peroxide treatment, in Deinococcus geothermalis, a radiation-resistant bacterium. D.
Ji Hyun Park +4 more
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Computational Analysis of the Tripartite Interaction of Phasins (PhaP4 and 5)-Sigma Factor (σ24)-DNA of Azospirillum brasilense Sp7. [PDF]
Polymers (Basel)Azospirillum brasilense Sp7 produces PHB, which is covered by granule-associated proteins (GAPs). Phasins are the main GAPs. Previous studies have shown phasins can regulate PHB synthesis. When A.
Aguilar-Carrillo Y +4 more
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