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Synthetic biology tools for engineering Corynebacterium glutamicum

Computational and Structural Biotechnology Journal, 2023
Corynebacterium glutamicum is a promising organism for the industrial production of amino acids, fuels, and various value-added chemicals. From the whole genome sequence release, C. glutamicum has been valuable in the field of industrial microbiology and
Gi Yeon Kim, Jinyoung Kim, Geunyung Park, Hyeon Jin Kim, Jina Yang, Sang Woo Seo   +5 more
doaj   +6 more sources

Advances and Perspectives for Genome Editing Tools of Corynebacterium glutamicum

Frontiers in Microbiology, 2021
Corynebacterium glutamicum has been considered a promising synthetic biological platform for biomanufacturing and bioremediation. However, there are still some challenges in genetic manipulation of C. glutamicum.
Qingzhuo Wang, Jiao Zhang, Jiao Zhang, Naief H. Al Makishah, Xiaoman Sun, Zhiqiang Wen, Zhiqiang Wen, Yu Jiang, Sheng Yang, Sheng Yang   +9 more
doaj   +2 more sources

Production of l-glutamate family amino acids in Corynebacterium glutamicum: Physiological mechanism, genetic modulation, and prospects

Synthetic and Systems Biotechnology, 2021
l-glutamate family amino acids (GFAAs), consisting of l-glutamate, l-arginine, l-citrulline, l-ornithine, l-proline, l-hydroxyproline, γ-aminobutyric acid, and 5-aminolevulinic acid, are widely applied in the food, pharmaceutical, cosmetic, and animal ...
Qi Sheng, Xiao-Yu Wu, Xinyi Xu, Xiaoming Tan, Zhimin Li, Bin Zhang   +5 more
doaj   +2 more sources

Eliminating the capsule-like layer to promote glucose uptake for hyaluronan production by engineered Corynebacterium glutamicum

Nature Communications, 2020
Bioproduction of hyaluronan needs increases in yield and greater diversity of the molecular weights. Here, the author increases hyaluronan production and diversifies the molecular weights through engineering the hyaluronan biosynthesis pathway and ...
Yang Wang, Litao Hu, Hao Huang, Hao Wang, Tianmeng Zhang, Jian Chen, Guocheng Du, Zhen Kang   +7 more
doaj   +2 more sources

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

Nature Communications, 2020
The regulation of higher-order chromosome folding and segregation in bacteria is poorly understood. Here, Böhm et al. provide insights into the roles of DNA partitioning protein ParB and SMC condensin complexes in Corynebacterium glutamicum.
Kati Böhm, Giacomo Giacomelli, Andreas Schmidt, Axel Imhof, Romain Koszul, Martial Marbouty, Marc Bramkamp   +6 more
doaj   +2 more sources

CRISPR-Cpf1 assisted genome editing of Corynebacterium glutamicum

Nature Communications, 2017
Corynebacterium glutamicum is an important industrial microbe, however it has proven difficult to genetically engineer using Cas9 from Streptococcus pyogenes.
Yu Jiang, Fenghui Qian, Junjie Yang, Yingmiao Liu, Feng Dong, Chongmao Xu, Bingbing Sun, Biao Chen, Xiaoshu Xu, Yan Li, Renxiao Wang, Sheng Yang   +11 more
doaj   +2 more sources

Efficient Multiplex Gene Repression by CRISPR-dCpf1 in Corynebacterium glutamicum

Frontiers in Bioengineering and Biotechnology, 2020
Corynebacterium glutamicum is an important workhorse for industrial production of diversiform bioproducts. Multiplex control of metabolic pathway genes is crucial for maximizing biosynthesis of desired products.
Mingyue Li, Mingyue Li, Jiuzhou Chen, Yu Wang, Jiao Liu, Jingwen Huang, Jingwen Huang, Ning Chen, Ping Zheng, Jibin Sun   +9 more
doaj   +2 more sources

Production of the Antimicrobial Roseoflavin With Genetically Engineered Corynebacterium glutamicum [PDF]

Microbial Biotechnology
The global rise of drug‐resistant bacterial infections underscores an urgent demand for novel antimicrobial agents. Roseoflavin, a naturally occurring riboflavin analog, has emerged as a promising candidate for drug development.
Luciana Fernandes Brito, Ane Bræin Aas, Rosa Jodalen Rudberg, Trygve Brautaset, Fernando Pérez‐García   +4 more
doaj   +2 more sources

Systems metabolic engineering of Corynebacterium glutamicum for efficient l-tryptophan production [PDF]

Synthetic and Systems Biotechnology
Corynebacterium glutamicum is a versatile industrial microorganism for producing various amino acids. However, there have been no reports of well-defined C. glutamicum strains capable of hyperproducing l-tryptophan.
Yufei Dong, Zhen Chen
doaj   +2 more sources

Chromosome segregation impacts on cell growth and division site selection in Corynebacterium glutamicum. [PDF]

, 2013
Spatial and temporal regulation of bacterial cell division is imperative for the production of viable offspring. In many rod-shaped bacteria, regulatory systems such as the Min system and nucleoid occlusion ensure the high fidelity of midcell divisome ...
Bramkamp, Marc, Donovan, Catriona, Krämer, Reinhard, Schauss, Astrid   +3 more
core   +14 more sources