Inefficient Secretion of Anti-sigma Factor FlgM Inhibits Bacterial Motility at High Temperature [PDF]
iScience, 2019 Summary: Temperature is one of the key cues that enable microorganisms to adjust their physiology in response to environmental changes. Here we show that motility is the major cellular function of Escherichia coli that is differentially regulated between
Iaroslav Rudenko +3 more
doaj +5 more sources
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core [PDF]
Nature Communications, 2016 Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind ...
Karthik V. Rajasekar +12 more
doaj +10 more sources
The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa. [PDF]
Mol Microbiol, 2021 During decades‐long infections in the cystic fibrosis (CF) airway, Pseudomonas aeruginosa undergoes selection. One bacterial genetic adaptation often observed in CF isolates is mucA mutations. MucA inhibits the sigma factor AlgU.
Schofield MC +7 more
europepmc +5 more sources
Metal-Responsive Transcription Factors Co-Regulate Anti-Sigma Factor (Rsd) and Ribosome Dimerization Factor Expression. [PDF]
Int J Mol Sci, 2023 Bacteria exposed to stress survive by regulating the expression of several genes at the transcriptional and translational levels. For instance, in Escherichia coli, when growth is arrested in response to stress, such as nutrient starvation, the anti ...
Yoshida H, Shimada T, Ishihama A.
europepmc +4 more sources
T3SS chaperone of the CesT family is required for secretion of the anti-sigma factor BtrA in Bordetella pertussis [PDF]
Emerging Microbes and Infections, 2023 Bordetella pertussis is a Gram-negative, strictly human re-emerging respiratory pathogen and the causative agent of whooping cough. Similar to other Gram-negative pathogens, B.
Jakub Držmíšek +4 more
doaj +3 more sources
Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution [PDF]
Biomolecules, 2015 Sigma factors are multi-domain subunits of bacterial RNA polymerase (RNAP) that play critical roles in transcription initiation, including the recognition and opening of promoters as well as the initial steps in RNA synthesis.
Mark S. Paget
doaj +5 more sources
PG1659 functions as anti-sigma factor to extracytoplasmic function sigma factor RpoE in Porphyromonas gingivalis W83. [PDF]
Mol Oral Microbiol, 2021 Summary Anti-sigma factors play a critical role in regulating the expression of sigma factors in response to environmental stress signals. PG1659 is cotranscribed with an upstream gene PG1660 (rpoE), which encodes for a sigma factor that plays an ...
Dou Y +4 more
europepmc +5 more sources
New Insights into the Regulation of Cell-Surface Signaling Activity Acquired from a Mutagenesis Screen of the Pseudomonas putida IutY Sigma/Anti-Sigma Factor [PDF]
Frontiers in Microbiology, 2017 Cell-surface signaling (CSS) is a signal transfer system that allows Gram-negative bacteria to detect environmental signals and generate a cytosolic response.
María A. Llamas +4 more
doaj +3 more sources
Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE. [PDF]
Sci Rep, 2019 σE is one of the 13 sigma factors encoded by the Mycobacterium tuberculosis chromosome, and its involvement in stress response and virulence has been extensively characterized.
Boldrin F +6 more
europepmc +6 more sources
RsrA, an anti-sigma factor regulated by redox change [PDF]
EMBO Journal, 1999 SigR (sigma(R)) is a sigma factor responsible for inducing the thioredoxin system in response to oxidative stress in the antibiotic-producing, Gram-positive bacterium Streptomyces coelicolor A3(2). Here we identify a redox-sensitive, sigma(R)-specific anti-sigma factor, RsrA, which binds sigma(R) and inhibits sigma(R)-directed transcription in vitro ...
Mark S B Paget +2 more
exaly +4 more sources