Dual-function enzyme acts as a global c-di-GMP sink and local anti sigma factor antagonist to drive cellular differentiation. [PDF]
PLoS GeneticsSoil bacteria of the genus Streptomyces are natural producers of over two-thirds of clinically used antibiotics. Their ability to generate these valuable metabolites is tightly linked to a developmental program involving the transition from vegetative ...
Buse Cınar Cakmak +7 more
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Structural insights into σ28-dependent transcription initiation and its regulation by anti-sigma factor in Pseudomonas aeruginosa. [PDF]
Nucleic Acids ResLate flagellar genes in Pseudomonas aeruginosa are transcribed by the group 3 sigma factor, FliA (σ28). σ28 drives the expression of flagellin, which assembles into the flagellar filament in this monoflagellated bacterium.
Sheenu +4 more
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A staphylococcal anti-sigma factor possesses a single-domain, carries different denaturant-sensitive regions and unfolds via two intermediates. [PDF]
PLoS One, 2018 RsbW, an anti-sigma factor possessing kinase activity, is expressed by many Gram-positive bacteria including Staphylococcus aureus. To obtain clues about the domain structure and the folding-unfolding mechanism of RsbW, we have elaborately studied rRsbW,
Sinha D +5 more
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Characterization and in vivo regulon determination of an ECF sigma factor and its cognate anti-sigma factor in Nostoc punctiforme. [PDF]
Mol Microbiol, 2017 Based on primary sequence comparisons and genomic context, Npun_F4153 (SigG)/Npun_F4154 (SapG) of the cyanobacterium Nostoc punctiforme were hypothesized to encode an ECF sigma factor/anti‐sigma factor pair. Transcription of sigG increased in heterocysts
Bell N, Lee JJ, Summers ML.
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Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in Chlamydia trachomatis [PDF]
Microbiology SpectrumPartner switching mechanisms (PSMs) are signal transduction systems comprised of a sensor phosphatase (RsbU), an anti-sigma factor (RsbW, kinase), an anti-anti-sigma factor (RsbV, the RsbW substrate), and a target sigma factor. Chlamydia spp.
Shiomi Junker +6 more
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Model peptide for anti-sigma factor domain HHCC zinc fingers: high reactivity toward 1O2 leads to domain unfolding. [PDF]
Chem Sci, 2019 The Zn(Cys)2(His)2 site of the anti-sigma factor ChrR reacts rapidly with 1O2 supporting its involvement in 1O2 sensing by this protein.
Chabert V +4 more
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Determinants of affinity and activity of the anti-sigma factor AsiA. [PDF]
Biochemistry, 2010 The AsiA protein is a T4 bacteriophage early gene product that regulates transcription of host and viral genes. Monomeric AsiA binds tightly to the sigma(70) subunit of Escherichia coli RNA polymerase, thereby inhibiting transcription from bacterial promoters and phage early promoters and coactivating transcription from phage middle promoters.
Gilmore JM +6 more
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Publisher Correction: Assessing the role of Rv1222 (RseA) as an anti-sigma factor of the Mycobacterium tuberculosis extracytoplasmic sigma factor SigE. [PDF]
Sci Rep, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Boldrin F +6 more
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The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection. [PDF]
PLoS One, 2019 Mucoid mucA22 Pseudomonas aeruginosa (PA) is an opportunistic lung pathogen of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients that is highly sensitive to acidified nitrite (A-NO2-).
Panmanee W +14 more
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Dual-specificity anti-sigma factor reinforces control of cell-type specific gene expression in Bacillus subtilis. [PDF]
PLoS Genet, 2015 Gene expression during spore development in Bacillus subtilis is controlled by cell type-specific RNA polymerase sigma factors. σFand σE control early stages of development in the forespore and the mother cell, respectively.
Serrano M +7 more
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