Results 31 to 40 of about 109,697 (226)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Influence of isochronal treatments on microstructure and mechanical properties of solution treated UNS S32750 SDSS alloy specimens

Journal of Materials Research and Technology, 2020
In this study, the influence of isochronal treatments performed at temperatures between 700 °C and 1060 °C and, with a treatment duration of 15 min, on microstructure and mechanical properties of a solution treated UNS S32750 Super Duplex Stainless Steel
Elisabeta Mirela Cojocaru, Doina Raducanu, Saleh Sabah Alturaihi, Anna Nocivin, George Coman, Vasile Danut Cojocaru   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Influence of σ Phase on the Allotropic Transformation of the Matrix in Co-Re-Cr-Based Alloys with Ni Addition

Metals, 2018
Co-Re-Cr alloys are being developed for high-temperature application in gas turbines. In these alloys, the Cr2Re3-based σ phase is stable when the Cr content is higher than 20 atomic %. The addition of Ni is being studied to partially substitute Cr,
Kai Dörries, Debashis Mukherji, Joachim Rösler, Katharina Esleben, Bronislava Gorr, Hans-Juergen Christ   +5 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Phase-field simulations of intergranular stress corrosion cracking in Fe-Cr-Ni alloy incorporating σ phase precipitation

Materials & Design
σ phase is a common precipitate in Fe-Cr-Ni alloy, which may significantly influence intergranular stress corrosion cracking (IGSCC). This influence stems primarily from the compositional segregation and elastic mismatch induced by σ phase precipitation,
Qionghuan Zeng, Yiming Chen, Meirong Jiang, Zhijun Wang, Lei Wang, Junjie Li, Jincheng Wang   +6 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Precipitation law of σ phase in 2205 duplex stainless steel

工程科学学报, 2015
After solution treatment at 1300℃ and cold rolling deformation at different reductions, 2205 duplex stainless steel was homogenized at different temperatures for different time intervals.
LI Shu-xia, REN Xue-ping, TONG Jian-guo, HOU Hong-liang   +3 more
doaj   +1 more source

Precipitation characteristics and tensile properties of high-nitrogen chromium-manganese steel fabricated by wire and arc additive manufacturing with isothermal post-heat treatment

Materials & Design, 2023
Wire and arc additive manufacturing (WAAM) technology is a promising method for fabricating high-performance protective materials and structural parts from high-nitrogen steel (HNS).
Xiaoyong Zhang, Yong Peng, Yong Huang, Kehong Wang, Jian Kong, Zhonghua Du, Tongli Wu, Ming Zhou   +7 more
doaj   +1 more source