Insulin enhances proliferation of hepatoma carcinoma cells by regulating the ubiquitination of glycolytic enzyme pyruvate kinase M2 [PDF]
, 2016 流行病学调查显示，胰岛素增加某些癌症的发病风险。胰岛素可作为一种生长因子促进细胞分裂；当体内有肿瘤细胞或突变细胞存在时，胰岛素可放大癌症的风险。但胰岛素对肿瘤细胞增殖调控的具体机制尚未明确。现有研究表明，丙酮酸激酶PKM2，在肿瘤中呈高表达，不仅是糖酵解限速酶，而且还具有转录因子活性，调控肿瘤细胞的增殖、迁移和侵袭过程，进而促进恶性肿瘤的发生发展。此外，核孤儿受体TR3能通过基因转录、蛋白质相互作用等参与细胞生长、自噬、增殖、凋亡、分化等生理过程，并且其功能发挥与亚细胞定位密切相关 ...
支蔷
core
Zhongguo shiyan zhenduanxue, 2012 丙型肝炎是一种由丙型肝炎病毒（HCV）感染而导致的疾病。是一种经血液和体液传染的疾病。我国属于丙型肝炎高发区,一般人群丙型肝炎病毒阳性率为3.2%（0.1%-10%）[1]。大约50%-85%的丙肝病毒感染者会进展为慢性丙肝,其中又有10%-15%的患者可能在感染后10 ...
罗军 +6 more
doaj
The role of jumping translocation breakpoint gene promoting instability of genome and the biological function of its protein and potential clinical value [PDF]
, 2014 染色体不稳定性是大多数肿瘤细胞特别是实体瘤细胞和体外转化细胞的基本特征。其表现形式包括整条染色体的获得或缺失，杂合缺失，染色体易位重排，基因扩增等。目前认为染色体不稳定是肿瘤形成的始发因素，出现在肿瘤进展的早期阶段。体内外各种损伤刺激导致的基因组DNA链的断裂是染色体不稳定的根本原因。我们的研究发现，跳跃易位断裂点基因（JTB）在胃癌、肝癌中存在广泛的基因扩增和基因易位行为，而基因的扩增和易位是DNA双链断裂后异常修复的最终结果。JTB基因的断裂易位将导致其编码跨膜结构域的基因序列丢失 ...
刘贇鹏
core
Controlling hepatitis C in Rwanda: a framework for a national response [PDF]
, 2017 With the introduction of direct-acting antiviral drugs, treatment of hepatitis C is both highly effective and tolerable. Access to treatment for patients, however, remains limited in low- and middle-income countries due to the lack of supportive health ...
Gupta, N +8 more
core +2 more sources
Steroid Receptor Coactivator 1 Promotes Human Hepatocellular Carcinoma Progression by Enhancing Wnt/-catenin Signaling [PDF]
, 2016 SRC-1（Steroidreceptorcoactivator1）不仅是雄激素受体（androgenreceptor，AR）和雌激素受体（estrogenreceptor，ER)等激素受体的转录辅激活因子，而且能辅激活许多转录因子。SRC-1在乳腺癌和前列腺癌的发生发展进程中起着重要的作用，但是人们对于它在肝癌发生发展进程中所起的作用仍不清楚。在本文中，我们报道了SRC-1在62.5%（25/40）的肝癌组织样本（humanhepatocellularcarcinoma，HCC）中过表达。敲低SRC ...
童章炜
core
Clinical characteristics of 527 cases with different HCV genotypes in Qinghai Province [PDF]
ObjectiveTo investigate the distribution patterns of hepatitis C virus (HCV) genotypes and their clinical characteristics in Qinghai Province, and to provide a theoretical basis for the elimination of hepatitis C in this region.MethodsA total of 527 ...
LI Faying, YU Guoying
core +1 more source
Zhongguo shiyan zhenduanxue, 2006 目的通过调查慢性丙型肝炎患者2型糖尿病并发率及其与所感染HCV基因型的关系,进一步证实糖尿病是否为丙型肝炎的肝外表现之一。方法采用荧光定量PCR技术和PCR-微板核酸杂交-ELASA技术对365例慢性丙型肝炎3、60例慢性乙型肝炎患者进行HBV、HCV定性、定量检测和HCV基因型分析并比较其与对照人群糖尿病并发率的差异。结果慢性丙型肝炎患者糖尿病并发率为32.60%,明显高于慢性乙型肝炎（9.70%）及对照组（8.29%）。合并糖尿病的慢性丙型肝炎患者血清ALT及TBIL水平显著高于未合并糖尿病者 ...
赵平, 王江滨, 焦健, 王剑英
doaj
Efficacy of direct-acting antiviral agents combined regimens for hepatitis C virus with different genotypes in Dehong Prefecture， Yunnan Province from 2022 to 2024 [PDF]
ObjectiveTo investigate the therapeutic effects of direct-acting antiviral agents (DAAs) combined regimens for hepatitis C virus (HCV) patients in Dehong Prefecture, Yunnan Province from 2022 to 2024, to analyze the characteristics of treatment failure ...
CAO Yanfen +10 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 1997 摘 要 对52例输血前无丙型肝炎的受血者及30例无输血的对照组随访检测ALT、抗-HCV、HCV RN A 等项目,进行输血后HCV 感染的前瞻性研究。结果显示, 52例受血者中有9例符合输血后丙型肝炎的诊断,发 生率为17. 3% , 而对照组30例无1例感染丙型肝炎病毒( HCV ) ,两组有统计学差异( P = 0. 02 < 0. 05) ,且趋势 检验i2 = 16. 67, P < 0.
崇雨田 彭文伟 姚集鲁
doaj
Viral hepatitis: a review of global prevalence and research progress toward elimination [PDF]
Viral hepatitis is one of the leading infectious diseases contributing to the global increase in mortality and posing a serious threat to global public health.
Congling QIU +8 more
core +1 more source