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B/C基因型的乙型肝炎病毒在不同ALT状态下对乙型肝炎相关性肾炎的差异性影响 [PDF]
【目的】探讨不同ALT状态下B/C基因型的乙型肝炎病毒对乙型肝炎相关性肾小球肾炎的差异性影响。【方法】回顾性分析兰州大学第一医院确诊为乙型肝炎相关性肾小球肾炎的患者558例,所选病人均病历完整,均接受过肾组织病理学检查,化验指标包括:丙氨酸氨基转移酶、肌酐、尿β2微球蛋白、尿N-乙酰-β-D-葡萄糖苷酶、血尿素氮、肾小球滤过率、乙型肝炎病毒载量及基因型。【结果】B型C型基因型的乙肝相关性肾小球肾炎均以弥漫性膜增生性肾病为主(57.9%vs.54.4%),其次为毛细血管内增生性肾小球肾炎(25.3%vs ...
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【目的】调查慢性乙型肝炎病毒感染患者的主观睡眠现状。【方法】以2019年1月至6月中山大学附属第三医院门诊慢性乙型肝炎病毒感染患者353例,采用嗜睡量表、失眠程度量表、睡眠质量量表、焦虑自评表和抑郁自评表对患者进行评分,并按照睡眠情况分级标准进行分组,收集患者性别、年龄、疾病诊断、是否抗病毒治疗及文化程度资料,通过卡方检验及多因素logistic回归分析睡眠情况的影响因素。【结果】慢性乙型肝炎病毒感染患者总体嗜睡率为47.88%,总体失眠率为53.26%,6.8%的患者睡眠质量很差。嗜睡的危险因素为焦虑(
郑小燕 +7 more
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本文对乙型肝炎病毒宫内感染的发生率及机理进行了研究。24例HBsAg阳性母亲的新生儿中,5例脐血AntiHBc-IgM阳性,1例引产儿肝组织HBV-DNA阳性(斑点杂交法)。宫内感染率为6/24(25.0%)6例母亲全无先兆流产及/或先兆早产病史。斑点杂交法检测24例HBsAg阳性母亲胎盘组织HBV-DNA,阳性23例。实验结果表明宫内感染发生率较高。胎盘组织可受HBV感染。母血漏入并非宫内感染的唯一途径。
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Progress towards elimination of mother-to-child transmission of hepatitis B virus infection in China: a modelling analysis. [PDF]
Objective: To determine the projected burden of hepatitis B virus (HBV) in China, the intervention strategies that can eliminate mother-to-child transmission (MTCT) by 2030 or earlier and the measurable parameters that can be used to monitor progress ...
Chan, P +10 more
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The psychometric properties of the quick inventory of depressive symptomatology-self-report (QIDS-SR) in patients with HBV-related liver disease [PDF]
Background: Comorbid depression in Hepatitis B virus (HBV) is common. Developing accurate and time efficient tools to measure depressive symptoms in HBV is important for research and clinical practice in China.
Duan, Zhong-ping +7 more
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New antiviral agents and new treatments on the horizon for the management of viral hepatitis
Transfusion dependant patients are at risk of acquiring transfusiontransmitted viral infections including Hepatitis B virus (HBV) and Hepatitis C (HCV). These infections can lead to cirrhosis and hepatic cancer. Standard treatment, although with improved
M. Sönmezoğlu
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The AMP-mimetic AICAR prevents HFD-promoted hepatosteatosis and inhibits liver tumorigenesis [PDF]
肝细胞癌(Hepatocellularcarcinoma)是最常见的肝脏原位肿瘤。肝癌的 危险因素包括酒精性肝疾病、非酒精性肝炎、肝炎病毒感染等。这些因素都和肝 癌形成中炎症有重要关系。肥胖人群中,肝脏脂质积累造成的非酒精性脂肪肝炎, 肥胖已成为肝癌形成的潜在危险因素。流行病学研究表明,超重和肥胖增加了癌 症发生的风险。在升高体重指数超标的肝癌患者中,由于肝癌死亡的风险是正常 人的4.5倍。文献报道,肥胖通过增加白介素6和肿瘤坏死因子的表达促进肝脏 炎性过程 ...
高建龙
core
Study on the risk factors for intrauterine infection of hepatitis B virus among pregnant women [PDF]
目的探讨厦门市孕妇乙型肝炎病毒(hepatitis B virus,HBV)感染情况和HBV宫内感染的影响因素。方法在1; 064名孕妇第一次到医院建立孕产妇保健卡时进行问卷调查并检测其血清乙肝标志物,根据检测结果选择外周血乙型肝炎表面抗原(hepatitis B; surface antigen,HBsAg)阳性的产妇179例随访至其分娩,并采集其分娩时的脐血和胎盘组织。对脐血进行HBsAg和HBV; DNA的检测,对胎盘组织进行HBsAg的检测。采用chi ...
刘惠芬 +9 more
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Objective To investigate the effect of Yao medicine foot bath therapy combined with mindfulness meditation on rehabilitation and sleep quality in chronic hepatitis B patients with liver stagnation and spleen deficiency syndrome.
JIANG Min (蒋敏) +2 more
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High-efficienct Construction of HBV-replicative Stable Cell Lines Based on ALL-IN-ONE Sleeping Beauty Transposon System [PDF]
乙型肝炎病毒(HepatitisBvirus,HBV)感染是全球范围内的重要公共卫生问题。HBV为嗜肝病毒,只能在肝细胞中增殖,目前HBV复制与抑制相关的研究大多采用HBV质粒瞬时转染Huh7或HepG2细胞的方法,但在进行药物筛查、病毒制备等需要稳定均一的实验条件时,稳定整合细胞株是更好的选择。HepG2.2.15和HepAD38是当前用于HBV研究的最常用的两株细胞株,其构建策略为随机整合方式,且这两株细胞株均为GenotypeD型。有研究表明,不同基因型乙型肝炎病毒有不同的地理分布特征,在复制 ...
吴勇
core

