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慢性乙型肝炎患者外周血淋巴细胞TCRαβ和TCRγδ的表达研究
Zhongguo shiyan zhenduanxue, 2006 目的检测慢性乙型肝炎患者外周血淋巴细胞TCRαβ和TCRγδ的表达,评价慢性乙型肝炎患者的细胞免疫状态,并初步探究随病情发展TCRαβ和TCRγδ表达率的变化趋势。方法流式细胞术测定38例慢性乙型肝炎、14例乙型肝炎肝硬化患者淋巴细胞中TCRαβ、TCRγδ的表达率。结果TCRαβ在慢性乙型肝炎患者中的表达率明显低于正常对照组 ...
邱莲女 +3 more
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Zhongguo shiyan zhenduanxue, 2009 目的乙型肝炎病毒六种主要基因型的分析,并探讨与乙肝血清标志物的关系。方法提取200例北京同仁医院乙型肝炎感染者血清核酸,采用型特异性引物PCR进行基因分型。用电化学发光法检测血清的乙型肝炎病毒表面抗原、表面抗体、e抗原、e抗体、核心抗体。结果B型占26%、C型64%、BC复合型10%;C型的HBeAg阳性率显著性高于B型,在不同的基因型中HBsAg转阴率无显著性差异。结论北方人群中C型占优势,且C型HBV不易发生HBeAg血清学转换。
王利君, 袁梁
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Zhongguo shiyan zhenduanxue, 2004 目的 探讨自体乙肝疫苗致敏的树突状细胞 （DC）对慢性乙型肝炎 （CHB）免疫治疗的作用。方法 取患者外周血 2 0ml分离单个核细胞 ,加入重组人粒细胞 巨噬细胞集落刺激因子 （rGM CSF）和白细胞介素 4 （IL 4 ）进行DC体外扩增 ,于培养第 5天加入 5 0 μg/ml乙型肝炎疫苗 ,7天收获细胞。 34例慢性乙肝患者根据年龄和发病时间分为治疗 1、2、3组 ,皮内回输DC。对照组患者注射等量生理盐水 ,均每周 1次 ,连续 8次。于回输DC后 2周检测患者血清乙型肝炎病毒DNA（HBV
赵岐刚, 田小侠, 张书广
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凝血常规在各型乙型病毒性肝炎、乙型肝炎后肝硬化患者中的检测及其临床意义
Zhongguo shiyan zhenduanxue, 2010 目的探讨凝血常规在各型乙型肝炎、乙型肝炎后肝硬化患者病变严重程度的临床价值。方法收集乙型肝炎、乙型肝炎后肝硬化患者样本75例,健康对照者样本20例,采用凝固法检测凝血酶原时间（PT）、国际标准化比值（INR）、凝血酶原时间活动度（PTA）、活化部分凝血活酶时间（APTT）、纤维蛋白原（FIB）等指标。结果 PTI、NR、PTA、APTT在各型乙型病毒性肝炎、肝硬化Child-Pugh A、B、C间两两比较差异均有统计学意义 ...
张玲, 李文娟, 安倍莹, 李玉香
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The Anatomical Record, Volume 306, Issue 12, Page 2945-2957, December 2023., 2023 Abstract Incipient diagnosis and noninvasive forecasts using urinary biomarkers are important for preventing diabetic kidney disease (DKD) progression, but they are also controversial. Previous studies have shown a potential relationship between urinary tubular biomarkers (UTBs) and traditional Chinese medicine (TCM) syndrome in patients with DKD. Thus,
Wei Wu +11 more
wiley +1 more source
Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023 Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan +5 more
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International Journal of Immunogenetics, Volume 50, Issue 6, Page 299-305, December 2023., 2023 Abstract Hepatitis B virus (HBV) is responsible for various liver diseases, such as chronic hepatitis B (CHB), liver fibrosis, liver cirrhosis (LC) and hepatocellular carcinoma (HCC), which pose a significant threat to human health. An ineffective immune response to HBV can result in viral chronicity.
Hai Cheng +3 more
wiley +1 more source
Veterinary Dermatology, Volume 34, Issue 6, Page 514-522, December 2023., 2023 Background – Pruritus is one of the most common reasons for dermatological consultations in the veterinary clinic. Treatment is normally multimodal and requires continuous monitoring and reassessment. New therapies are needed to broaden the therapeutic arsenal.
Xavier Serra Fabregat +5 more
wiley +1 more source
Integrative Conservation, Volume 2, Issue 3, Page 133-139, September 2023., 2023 Invertebrate‐derived DNA (iDNA) has enabled the identification and quantification of ecological interactions within trophic networks and its use in biodiversity assessment. The dung beetle iDNA currently uses live beetles. However, the effectiveness of the iDNA approach hinges on the successful detection of mammalian DNA from specimens collected via ...
Thilina S. Nimalrathna +3 more
wiley +1 more source
The psychometric properties of the quick inventory of depressive symptomatology-self-report (QIDS-SR) in patients with HBV-related liver disease [PDF]
, 2017 Background: Comorbid depression in Hepatitis B virus (HBV) is common. Developing accurate and time efficient tools to measure depressive symptoms in HBV is important for research and clinical practice in China.
Duan, Zhong-ping +7 more
core +2 more sources