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睾丸支持细胞糖脂代谢在生精细胞发育中的作用及机制 [PDF]

浙江大学学报. 医学版
睾丸支持细胞在精子发生过程中起重要作用。精子发生的异常与睾丸支持细胞糖脂代谢紊乱密切相关。睾丸支持细胞的代谢环境为缺氧，其主要的代谢方式包括糖酵解和脂肪酸β氧化，其中糖酵解是睾丸支持细胞为生精细胞提供能量的经典途径，而脂肪酸β氧化可能是睾丸支持细胞产生腺苷三磷酸的主要途径。目前睾丸支持细胞糖脂代谢与生精细胞发育的关系、糖代谢与脂代谢之间的联系尚不明确。包括性激素在内的多种激素可以通过调控内分泌影响睾丸支持细胞糖代谢。AMPK、mTOR ...
李 舒豪, 孔 亮, 梁 景岩, 马 坦
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Decreased in n‐3 DHA enriched triacylglycerol in small extracellular vesicles of diabetic patients with cardiac dysfunction 糖尿病合并心脏功能障碍患者细胞外小囊泡中n‐3 DHA 富集的三酰甘油减少

Journal of Diabetes, Volume 15, Issue 12, Page 1070-1080, December 2023., 2023
Highlights Lipid profiles of small extracellular vesicles (sEVs) in patients with diabetes or diabetic cardiovascular disease are rarely reported. n‐3 docosahexaenoic acid (DHA)‐enriched triacylglycerol (TG) was found to decrease in sEVs from serum of patients with diabetic cardiovascular disease (DM‐CAD).
Wei Ding, Xuejuan Zhang, Dandan Xiao, Wenguang Chang   +3 more
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代谢性脑血管病：概念、方法、挑战和未来方向 Cerebro-Metabolic Disease: Concept, Method, Challenge and Future Directions

Zhongguo cuzhong zazhi, 2023
代谢危险因素是导致心脑血管病的重要原因。目前代谢性心血管病已有明确的概念和综合管理体系，而在我国发病率高、异质性强的脑血管病领域，尚未形成统一的代谢性脑血管病的定义和概念。本文综述脑血管病的代谢危险因素，提出代谢性脑血管病的概念和分类，阐述基于多组学技术的多学科、多器官水平的研究方法，介绍近年来涌现的具有心血管获益的代谢药物的特点及未来面临的挑战和研究方向，为代谢性脑血管病的综合管理提供理论依据。 Abstract: Metabolic risk factors are important ...
许杰，王拥军
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The link between obesity and insulin resistance among children: Effects of key metabolites 儿童肥胖与胰岛素抵抗之间的联系:关键代谢产物的影响

Journal of Diabetes, Volume 15, Issue 12, Page 1020-1028, December 2023., 2023
Highlights Childhood obesity was significantly associated with the increased risk of insulin resistance (IR). There were 12 metabolites co‐associated with childhood obesity and IR, including seven amino acid and five fatty acid metabolites. The combination of body mass index standard deviation score and key metabolites could effectively predict the ...
Wu Yan, Su Wu, Qianqi Liu, Qingqing Zheng, Wei Gu, Xiaonan Li   +5 more
wiley   +1 more source

A network meta‐analysis of association between cardiometabolic risk factors and COVID‐19 outcome severity 心血管代谢危险因素与COVID‐19严重程度关联的网络荟萃分析

Journal of Diabetes, Volume 15, Issue 11, Page 968-977, November 2023., 2023
Highlights Among 301 studies, diabetes mellitus was the most studied cardiometabolic risk factor. In the network meta‐analysis, cerebrovascular disease had the highest impact (relative risk [RR] 1.69; 95% CI, 1.65–1.73) on COVID‐19 outcomes compared to other cardiometabolic risk factors.
Alina Binbin Li, Bo Yang, Yufei Li, Rachel Huynh, Samuel Shim, Kenneth Lo, Jie Li, Andrew Zullo, Wen‐Chih Wu, Simin Liu   +9 more
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Osteoarthritis and risk of type 2 diabetes: A two‐sample Mendelian randomization analysis 骨关节炎与2型糖尿病的风险:一项双样本孟德尔随机化分析

Journal of Diabetes, Volume 15, Issue 11, Page 987-993, November 2023., 2023
Highlights We used data from the genome‐wide association studies database and two‐sample mendelian randomization method, we found that genetic evidence supporting that knee osteoarthritis is a potential risk factor for type 2 diabetes. Abstract Background Physical inactivity is an independent risk factor for type 2 diabetes (T2D).
Xing Xing, Yining Wang, Faming Pan, Guoqi Cai   +3 more
wiley   +1 more source

Sensitivity to thyroid hormone and risk of components of metabolic syndrome in a Chinese euthyroid population 中国甲状腺功能正常人群对甲状腺激素的敏感性和代谢综合征组分的风险

Journal of Diabetes, Volume 15, Issue 10, Page 900-910, October 2023., 2023
Highlights Mild acquired impaired thyroid hormone sensitivity was widespread among the general populations. Reduced thyroid hormone sensitivity was related with metabolic syndrome and its components. Impaired thyroid hormone sensitivity might affect the distribution of adipose tissue and muscle.
Fang Lv, Xiaoling Cai, Yufeng Li, Xiuying Zhang, Xianghai Zhou, Xueyao Han, Linong Ji   +6 more
wiley   +1 more source

Beta‐cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced? 2型糖尿病患者的β细胞功能:能被保留或增强吗?

Journal of Diabetes, Volume 15, Issue 10, Page 817-837, October 2023., 2023
Highlights Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of beta‐cell function and mass. Numerous mechanisms of beta‐cell failure are involved. Preservation and/or enhancement of beta‐cell function is of great importance in delaying the progression of T2DM and the burden of its complications. Accurate evaluation of the effects of
Laure Sayyed Kassem, Aman Rajpal, Margarita Victoria Barreiro, Faramarz Ismail‐Beigi   +3 more
wiley   +1 more source

Observing and interpreting clinical process: Methods and findings from ‘Layered analysis’ of parent–infant psychotherapy

Infant Mental Health Journal: Infancy and Early Childhood, Volume 44, Issue 5, Page 691-704, September 2023., 2023
Abstract This paper describes a method for investigating clinical process, Layered Analysis, which combines therapist countertransference reports and multi‐faceted microanalytic research approaches. Findings from the application of Layered Analysis to video‐recorded micro‐events of rupture and repair in four psychoanalytic parent–infant psychotherapy ...
Tessa Baradon, Evrinomy Avdi, Michelle Sleed, Björn Salomonsson, Keren Amiran   +4 more
wiley   +1 more source

Increased glutamate in type 2 diabetes in the Korean population is associated with increased plasminogen levels 韩国2型糖尿病患者谷氨酸升高与纤溶酶原水平升高有关

Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023
Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee, Jeong Won Yeom, Ji Ho Yun, Han Byul Jang, Min‐Gyu Yoo, Hyo‐Jin Kim, Soo Kyung Koo, Hye‐Ja Lee   +7 more
wiley   +1 more source