浙江大学学报. 医学版皮肤纤维化主要是指成纤维细胞过度增殖和细胞外基质过度沉积这一过程，会导致增生性瘢痕、瘢痕疙瘩、系统性硬化病等疾病。皮肤纤维化是一个动态变化的复杂过程，各种皮肤常驻细胞以及炎症细胞互相作用，最终导致细胞外基质沉积，甚至呈现侵袭性生长特征。细胞的表型及其功能的实现依赖于动态的细胞代谢反应，而细胞信号转导又与细胞代谢密切偶联。由于皮肤纤维化微环境中的细胞代谢-信号偶联对于炎症反应和纤维化活化至关重要，调节这些代谢途径可以为抑制甚至逆转皮肤纤维化进展的治疗提供新视角。本文系统回顾了皮肤纤维化中各类细胞的代谢特征，
钱 姝桐 +3 more
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中西医结合护理, 2022 Objective To investigate the effect of multidisciplinary team management by using the PDCA approach in blood glucose control of elderly patients with type 2 diabetes in the non-endocrinology department.
FAN Meihong (樊美红) +1 more
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Progress of clinical observation and nursing of patients with pituitary apoplexy (垂体危象患者的临床观察与护理进展)
中西医结合护理, 2022 Given the complex of clinical classification in pituitary apoplexy, it is required to carry out detailed observation, timely treatment and comprehensive nursing for patients with pituitary apoplexy. This paper reviewed studies of clinical observation and
LIANG Qian (梁倩) +1 more
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Application Progress of Omics Technology in Monascus sp. Research(组学技术在红曲霉研究中应用的进展) [PDF]
Shipin kexue jishu xuebao, 2023 The development of omics technologies (OTs) has expanded our understanding of growth and development, synthesis of metabolites, and the mechanisms of metabolic regulation in Monascus sp..
WANG Changlu(王昌禄) +4 more
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Effects of Mepiquat Exposure on Rat Urine Based on Metabolomics(基于代谢组学分析缩节胺暴露对大鼠尿液的影响) [PDF]
Shipin kexue jishu xuebaoMepiquat (Mep) is a food contaminant produced usually during heat processing. It is formed by Maillard reaction with free lysine, reducing sugar and alkylating agent under typical roasting conditions.
HU Chuanqin(胡传芹) +3 more
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Isolation and Identification of Secondary Metabolites from Halophytic Helianthustuberosus Tuber-Derived Fungus [PDF]
, 2016 盐生植物菊芋(Helianthus tuberosus)是一种新型经济作物,特殊生境可能会使其内生真菌产生特殊的次生代谢产物,如结构新颖或活性显著的化合物.为研究这种耐盐植物内生真菌的次生代谢产物以及植物宿主和内生真菌之间可能存在的关系,本实验室从耐盐菊芋块茎中分离纯化出10株内生真菌,对这10株内生真菌进行抗卤虫活性筛选,初步筛选出1株抗卤虫活性良好的菌株Mucor sp.ht-7,规模发酵后通过提取分离技术得到7个化合物,用波谱手段鉴定了7个化合物的结构 ...
季乃云 +3 more
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Metabolite Characteristics Analysis During Fermentation of Laobaigan Baijiu Based on Non-Targeted Metabonomics Technology(基于非靶向代谢组学技术解析老白干白酒发酵过程中的代谢物特征) [PDF]
Shipin kexue jishu xuebaoMetabolites during Baijiu fermentation process are closely related to its unique style characteristics. Characteristics and succession of metabolites for Laobaigan Baijiu during its fermentation process have not been comprehensively analyzed.
GENG Xiaojie(耿晓杰) +8 more
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Research Progress of Lactic Acid Bacteria Genome-Scale Metabolic Models(乳酸菌基因组代谢网络模型的研究进展) [PDF]
Shipin kexue jishu xuebao, 2021 Genome-scale metabolic models (GEMs/GSMM) are cellular biochemical reaction networks of the genomic scale, which can quantitatively describe the relationship between genes and phenotypes,and be widely used in systems biology, metabolic engineering ...
AI Lianzhong(艾连中) +1 more
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UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
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Research Progress on Flavor of Chinese Cereal Vinegars(中国谷物醋风味研究进展) [PDF]
Shipin kexue jishu xuebao, 2021 Vinegar is an indispensable condiment in people's life, the most widely used acid condiment in the world. China, Japan, Korea and other Asian countries mostly use sorghum, rice, glutinous rice and other grains as raw materials to ferment and produce ...
WANG Min(王敏) +3 more
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