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Journal of Diabetes, Volume 15, Issue 10, Page 817-837, October 2023., 2023 Highlights Type 2 diabetes mellitus (T2DM) is characterized by progressive loss of beta‐cell function and mass. Numerous mechanisms of beta‐cell failure are involved. Preservation and/or enhancement of beta‐cell function is of great importance in delaying the progression of T2DM and the burden of its complications. Accurate evaluation of the effects of
Laure Sayyed Kassem +3 more
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Infant Mental Health Journal: Infancy and Early Childhood, Volume 44, Issue 5, Page 691-704, September 2023., 2023 Abstract This paper describes a method for investigating clinical process, Layered Analysis, which combines therapist countertransference reports and multi‐faceted microanalytic research approaches. Findings from the application of Layered Analysis to video‐recorded micro‐events of rupture and repair in four psychoanalytic parent–infant psychotherapy ...
Tessa Baradon +4 more
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Journal of Diabetes, Volume 15, Issue 9, Page 777-786, September 2023., 2023 Highlights Increased glutamate is associated with the development of diabetes. Glutamate increases plasminogen (PLG) levels through glutamate metabotropic receptor 5 activation with various insulin resistance‐related stresses. Glutamate inhibits the conversion of PLG to plasmin by increasing plasminogen activator inhibitor‐1.
Hyo Jung Lee +7 more
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Journal of Diabetes, Volume 15, Issue 9, Page 787-798, September 2023., 2023 Highlights Laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are effective for reducing weight and improving metabolic parameters in Chinese patients with obesity. These interventions resulted in improved glycemic control, as evidenced by decreased glycated hemoglobin levels, reduced insulin resistance, and improved ...
Wenhuan Feng +6 more
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Isolation and Identification of Secondary Metabolites from Halophytic Helianthustuberosus Tuber-Derived Fungus [PDF]
, 2016 盐生植物菊芋(Helianthus tuberosus)是一种新型经济作物,特殊生境可能会使其内生真菌产生特殊的次生代谢产物,如结构新颖或活性显著的化合物.为研究这种耐盐植物内生真菌的次生代谢产物以及植物宿主和内生真菌之间可能存在的关系,本实验室从耐盐菊芋块茎中分离纯化出10株内生真菌,对这10株内生真菌进行抗卤虫活性筛选,初步筛选出1株抗卤虫活性良好的菌株Mucor sp.ht-7,规模发酵后通过提取分离技术得到7个化合物,用波谱手段鉴定了7个化合物的结构 ...
季乃云 +3 more
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UVA Assisted 4-Thiothymidine for Cancer Treatment [PDF]
, 2016 This article reviews the developments of 4-thiothymidine analogues, assisted with UVA light, as a novel cancer therapy. First, the key points on synthetic chemistry, photochemistry and cellular toxicity of 4-thiothymidine are summarized.
Feng, Luo +3 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2021 目的比较食管鳞癌患者和健康志愿者的血清代谢谱，寻找食管鳞癌特有的代谢标志物。方法选择一组明确诊断的食管鳞癌患者作为实验组、一组健康志愿者作为对照组，以液相色谱-质谱法（LC-MS）检测其血清轮廓代谢谱，通过单变量分析和多变量（主成分分析及偏最小二乘回归分析法等）比较两组代谢谱并寻找差异性代谢物，通过代谢物质通路的富集分析探讨其可能异常生物学过程。结果入组食管鳞癌患者20例为实验组，健康对照20例为对照组，变异倍数分析和T检验等单因素分析结果得出21种差异性代谢物（P<0.05）；选择单变量分析P ...
黄伟钊 +5 more
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代谢性脑血管病：概念、方法、挑战和未来方向 Cerebro-Metabolic Disease: Concept, Method, Challenge and Future Directions
Zhongguo cuzhong zazhi, 2023 代谢危险因素是导致心脑血管病的重要原因。目前代谢性心血管病已有明确的概念和综合管理体系，而在我国发病率高、异质性强的脑血管病领域，尚未形成统一的代谢性脑血管病的定义和概念。本文综述脑血管病的代谢危险因素，提出代谢性脑血管病的概念和分类，阐述基于多组学技术的多学科、多器官水平的研究方法，介绍近年来涌现的具有心血管获益的代谢药物的特点及未来面临的挑战和研究方向，为代谢性脑血管病的综合管理提供理论依据。 Abstract: Metabolic risk factors are important ...
许杰，王拥军
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野生动物学报, 2020 行为训练做一种丰容手段，在圈养野生动物管理中正逐渐运用。其目的是通过正强化刺激，让动物学会指令配合动物管理，从而减少胁迫。然而目前并没有合适的生理指标来评价训练对动物的影响。本实验对象是杭州动物园饲养的2只黑叶猴，通过对其中1只“大杭”个体进行持续30 d的正强化行为训练，训练目标为肌肉注射。通过GC-MS代谢组手段测定粪便所有代谢产物。模型显示，行为训练后大杭粪便代谢组与训练前具有显著的区别（PLS-DA：R2y=0.951，Q2=0.502；（O）PLS-DA：R2y=0.95，Q2=0.454 ...
何鑫, 王福云, 张秀秀, 朱岩
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Zhongguo shiyan zhenduanxue, 2021 代谢综合征(MS)是一组以肥胖、高脂血症、糖尿病、高尿酸血症以及高血压等聚集发病的代谢紊乱症候群。随着人们生活方式改变,生活压力增大,以及不良饮食习惯的增加,代谢综合征的发病率逐渐升高。代谢综合征发病率的提高大大增加了其下游疾病,如动脉粥样硬化性心血管疾病、肝功能障碍等发生的风险,代谢综合征已成为威胁大众健康的严重公共卫生问题。随着对代谢综合征研究的不断深入,现已逐渐达成共识,认为代谢综合征发生的根本原因可能是慢性低度炎症反应[1]。
詹妮 +4 more
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