Results 21 to 30 of about 42,433 (259)
基于超高效液相色谱-静电场轨道阱高分辨质谱的深静脉血栓模型大鼠血浆代谢组学分析
Se pu = Chinese journal of chromatography, 2022 深静脉血栓(DVT)是一种血栓栓塞性疾病,具有高发病率、高死亡率和高后遗症3大特点。采用左股静脉不完全结扎加高渗盐水刺激建立DVT大鼠模型,使用超高效液相色谱-静电场轨道阱高分辨质谱(UHPLC-Orbitrap HRMS)检测假手术组与DVT模型组的血浆代谢谱,用主成分分析(PCA)及正交偏最小二乘-判别分析(OPLS-DA)对代谢组数据进行多元统计分析,观察两组间的代谢表型差异,将多变量模型分析中的变量重要性值(VIP>1)以及代谢物在模型组中的变化倍数(FC≤0.5或FC≥2 ...
Yan Gu +4 more
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Progress of clinical observation and nursing of patients with pituitary apoplexy (垂体危象患者的临床观察与护理进展)
中西医结合护理, 2022 Given the complex of clinical classification in pituitary apoplexy, it is required to carry out detailed observation, timely treatment and comprehensive nursing for patients with pituitary apoplexy. This paper reviewed studies of clinical observation and
LIANG Qian (梁倩) +1 more
doaj +1 more source
Journal of Diabetes, Volume 15, Issue 9, Page 787-798, September 2023., 2023 Highlights Laparoscopic sleeve gastrectomy and laparoscopic Roux‐en‐Y gastric bypass are effective for reducing weight and improving metabolic parameters in Chinese patients with obesity. These interventions resulted in improved glycemic control, as evidenced by decreased glycated hemoglobin levels, reduced insulin resistance, and improved ...
Wenhuan Feng +6 more
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高效液相色谱-串联质谱法快速同时测定土壤中草甘膦、草铵膦及其代谢物
Se pu = Chinese journal of chromatography, 2022 建立了快速同时测定土壤中草甘膦(GLY)、草铵膦(GLUF)及其代谢物的高效液相色谱-串联质谱(HPLC-MS/MS)分析方法。分别对前处理和色谱-质谱条件进行优化,样品采用0.5 mol/L氨水作为溶剂振荡提取,离心,上清液过滤膜后,直接采用HPLC-MS/MS测定,电喷雾离子源(ESI-),多反应监测(MRM)模式下检测,外标法定量。结果表明,采用Dikma Polyamino HILIC色谱柱(150 mm×2.0 mm, 5 μm)进行分离,目标化合物峰形良好,响应值高 ...
H. Ping +6 more
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[Advances in Research on Cell Metabolic Interactions in the Tumor Microenvironment]. [PDF]
Sichuan Da Xue Xue Bao Yi Xue Ban代谢重编程对肿瘤的发生和发展至关重要。肿瘤细胞的代谢及增殖受到细胞内在因素和肿瘤微环境（tumor microenvironment, TME）中代谢物的共同调节。TME中的代谢主要受到3个层面的调节：肿瘤代谢本身内在因素的调节；肿瘤细胞与T细胞、髓系细胞、基质细胞之间代谢产物的相互影响；肿瘤细胞在组织空间中的代谢异质性。本文就肿瘤细胞不同的代谢调节模式进行了简要概述，并深入剖析了肿瘤细胞与TME中其他细胞的代谢相互影响，以及各类细胞的代谢特征和功能情况。这进一步为肿瘤的精准治疗提供了理论基础和新的思路。
Wu P, Yang Z, Li Q, Wang D.
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Mechanisms of bariatric surgery for weight loss and diabetes remission 减重手术减轻体重和缓解糖尿病的机制
Journal of Diabetes, Volume 15, Issue 9, Page 736-752, September 2023., 2023 Highlights Controversial changes in intestinal hormones after bariatric surgery (BS) were summarized. The changes of signaling proteins involved in insulin resistance and the newly proposed changes in growth differentiation factor 15, exosomes, and extracellular vesicles after BS were elucidated.
Mengsha Yin +6 more
wiley +1 more source
Se pu = Chinese journal of chromatography, 2022 植物次生代谢物在抵御生物/非生物胁迫、生物间互作以及信息传递等方面发挥重要作用,次生代谢途径解析对植物分子育种、天然产物合成等方面具有重要意义。液相色谱-高分辨串联质谱(LC-HRMS/MS)为次生代谢物鉴定及途径表征提供了技术手段。非靶向LC-HRMS/MS方法可获得丰富的质谱信号,包括一级质谱和二级质谱(MS, MS/MS),但受质谱数据库规模以及次生代谢物复杂性的制约,次生代谢物注释十分困难。该研究以玉米叶片中苯丙烷途径代谢物为例,发展用于非靶向代谢组数据中重要途径代谢物的高效筛选和注释新方法 ...
Zaifang Li +8 more
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中西医结合护理, 2022 Objective To investigate the effect of multidisciplinary team management by using the PDCA approach in blood glucose control of elderly patients with type 2 diabetes in the non-endocrinology department.
FAN Meihong (樊美红) +1 more
doaj +1 more source
Journal of Diabetes, Volume 15, Issue 8, Page 640-648, August 2023., 2023 Highlights In Chinese postmenopausal women with type 2 diabetes mellitus, serum follicle‐stimulating hormone levels were negatively and independently associated with the prevalence of nonalcoholic fatty liver disease. Metabolic conditions, including overweight/obesity, central obesity, hyperuricemia, hypertension, and dyslipidemia did not interact with
Shengjie Ge +10 more
wiley +1 more source
分散固相萃取-超高效液相色谱-串联质谱法测定农产品中乙拌磷及其代谢物
Se pu = Chinese journal of chromatography, 2022 基于超高效液相色谱-串联质谱(UHPLC-MS/MS)建立定量分析乙拌磷及其5个代谢物(乙拌磷砜、乙拌磷亚砜、内吸磷-S、内吸磷-S-砜、内吸磷-S-亚砜)的方法,应用该方法分析其在农产品(豌豆、芦笋、小麦、咖啡豆和花生)中的残留量。对样品前处理及色谱条件进行优化,样品经过乙腈涡旋提取(小麦、咖啡豆和花生先加水润湿),经盐析分层,取上清液经50 mg C18、50 mg PSA和50 mg NH2混合分散固相萃取净化后,经Thermo Syncronis C18色谱柱(150 mm×2.1 mm, 5 ...
Qiang Sun +5 more
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