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Preparation of copolymer 7-hydroxyethyl chrysin loaded PLGA nanoparticles and the in vitro release. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban目的 制备和评价7-羟乙基白杨素（7-HEC）聚乳酸-羟基乙酸共聚物（PLGA）纳米粒。 方法 采用乳化溶剂挥发法制备7-HEC/PLGA纳米粒，以粒径、多分散系数（PDI）、包封率、载药量及Zeta电位为评价指标，通过单因素考察结合Box-Behnken响应面法优化处方。采用甘露醇作为冻干保护剂制备冻干粉，对最优处方制备的7-HEC/PLGA纳米粒进行表征及体外释放研究。 结果 经Box-Behnken响应面法优化后的最优处方为：药载比2.12∶20，油水体积比1∶14.7，乳化剂为2.72%大豆磷脂。
Wang X +6 more
europepmc +2 more sources
亚洲临床医学杂志, 2020 随着医学的发展，心脏康复已成为心脏病治疗领域的热点。体外反搏作为心脏康复中的一个无创、有效、安全的治疗措施，发挥着重要的作用。但其在心脏康复方面的作用及机制尚不完全清楚，现就近几年的相关文献综述体外反搏在心脏康复中的应用进展。
艳飞 陈, 英霞 郝
semanticscholar +1 more source
实用医学研究, 2020 体外诊断试剂临床试验对于疾病诊断和及时治疗具有重要作用，不断完善和优化临床试验，是十分必要的。研究首先阐述体外诊断试剂临床试验相关概念，随后分析其中存在的问题，并在此基础上提出针对性的优化措施。旨在通过此次研究明确中国当下体外诊断试剂临床试验中存在的不足，并为后续监管与优化提供依据。
云鹏 刘, 承锦 刘
semanticscholar +1 more source
, 2017 本文旨在探讨半滑舌鳎(Cynoglossus semilaevis)垂体细胞的体外原代培养方法。采用胰蛋白酶消化法，垂体细胞能够在含有5%的胎牛血清、100 U/mL青霉素和100 μg/mL链霉素的L-15完全培养基中，在24℃培养箱中，在不添加细胞生长因子的条件下培养7天以上，并分泌促性腺激素。结果显示，建立的垂体细胞原代培养方法适用于亲鱼和成鱼。体外原代培养的细胞既可以应用其开展相关的生殖生理研究，也可以从细胞层面探讨营养素发挥生殖调控的作用机制，为亲鱼营养调控机制研究提供便捷的实验材料。 The
黄滨 +5 more
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Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.Abstract This study explored the demographic and psychosocial characteristics, and presenting concerns of new or expectant fathers seeking perinatal mental health (PMH) support through the Australia‐based ForWhen service, compared to a sample of mothers.
Sophia A. Harris +2 more
wiley +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.Abstract Parental reflective functioning (PRF), a critical construct in the field of infant mental health, has been under investigated in non‐WEIRD countries, where the majority of the world's infants are born. Studies from WEIRD contexts have demonstrated a relationship between socio‐demographic and parental reflective functioning scores.
Nicola Dawson +2 more
wiley +1 more source
基于酪氨酸磷酸酶(PTP1B)的II型糖尿病药物设计、合成和体外活性及毒性的初步评价
, 2016 酪氨酸磷酸酶PTP1B已被公认为治疗II型糖尿病药物的理想靶标蛋白.通过重组表达制备PTP1B蛋白及其蛋白质晶体,并尝试将其与768种小分子片段进行以结构为基础的筛选,得到了数个与PTP1B结合的小分子片段及其化学结构.在此基础上利用计算机辅助药物设计方法设计与优化出一种新型PTP1B抑制剂,并经13步反应合成了该目标分子.体外药理活性和毒性的初步评价的结果表明,其对体外重组人源PTP1B的酪氨酸磷酸酶活性半数抑制浓度IC50值达到（3.4±1.2）μmol/L,优于阳性对照;在Hep ...
卢骋 +6 more
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Risk, Hazards &Crisis in Public Policy, EarlyView.Abstract Norway's oil sector faces significant security challenges due to rapid technological advancements and heightened geopolitical tensions, particularly concerning threats from Russian drones. The sector maintains a vigilant approach, continually monitoring and adapting to evolving threats.
Riana Steen, Tommy B. Hansen
wiley +1 more source
Implications of Tobacco Use on Pathogen‐Driven Diseases: A Public Health and Policy Perspective
World Medical &Health Policy, EarlyView.ABSTRACT The tobacco epidemic remains one of the most significant global public health challenges, responsible for over 8 million deaths annually, with a substantial portion occurring among non‐smokers exposed to second‐hand smoke. While cigarette smoking remains the most prevalent form of tobacco use worldwide, the rise of electronic nicotine delivery
Nadine Kabbani, James L. Olds
wiley +1 more source
Understanding Self‐Rated Health: Examining the Mediating Effect of Self‐Efficacy
World Medical &Health Policy, EarlyView.ABSTRACT Understanding self‐rated health (i.e., individuals' perception of their health status) is essential because it not only serves as a reliable and valid indicator of population and individual health, but also provides an important basis to formulate health policies and to evaluate the effectiveness of these policies (Salomon et al., 2009 ...
Ho Man Leung +2 more
wiley +1 more source