Division of Gastrointestinal Pathophysiology [PDF]
この論文は国立情報学研究所の学術雑誌公開支援事業により電子化されまし
山本 武, 門脇 真
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Mindin is up-regulated during colitis and enhances inflammation by activating the transcription activity of NF-κB protein family [PDF]
炎症性肠病(IBD)的发生,被认为是遗传、环境和黏膜免疫三方面因素共同作用的结果,而肠黏膜异常的免疫应答又是发病的关键因素之一。在炎症局部,炎性细胞的招募和激活依赖各种细胞膜受体及整合素与细胞基质(ECM)间的相互作用。细胞外基质蛋白Mindin是Mindin/F-spondin家族成员,在小鼠炎症模型中,有多项研究表明Mindin在免疫应答过程中扮演重要角色,但对于其在炎症中的功能和调控机制研究较少。故本课题拟探索肠炎中Mindin的表达水平及其在炎症中的信号调控机制。 本课题研究中 ...
李萍
core
Construction of CpG-Au@HBc virus like particles and study of their membrane translocation mechanism, immunostimulary effect [PDF]
乙肝病毒核心蛋白病毒样颗粒(HepatitisvirusBviruscoreproteinviruslikeparticles,HBcVLPs)因其不具有乙肝病毒的复制能力而又具备较强的免疫原性而被广泛应用于构建新型疫苗。另一方面,HBcVLPs的正二十面体空腔结构和解聚/自组装特性使得其还能够作为纳米载体呈递基因、纳米粒子等。本课题利用HBcVLPsC末端的富集正电荷序列可以通过静电吸引力与核酸相互作用的特点,构建了一种同时包裹有CpG寡核苷酸链(CpGODNs)佐剂和金纳米粒子的HBcVLPs ...
王雅润
core
[Guardians of Immune Tolerance: Regulatory T Cells]. [PDF]
Ming K, Zhang H, Hu H.
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[Progress in Immunotherapy for Pulmonary Lymphoepithelioma Carcinoma]. [PDF]
Sun W +5 more
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[Role of Trained Immunity in the Association Between Periodontitis and Rheumatoid Arthritis]. [PDF]
You R, Cui Y, Sun J.
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Ferroptosis and tumor immunity. [PDF]
Tao Q +6 more
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[Immune Checkpoints Mediate Tumor Immune Regulation through Metabolic Pathways]. [PDF]
Du W +6 more
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Allogeneic hematopoietic stem cell transplantation from anHLA-haploidentical related donor based on feto-maternal tolerance [PDF]
Aoyama, Kazutoshi +7 more
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