【目的】 通过建立肠缺血—再灌注的动物实验模型,研究异搏定65380;能量合剂对大鼠肠缺血—再灌注所致肝损伤的作用65377; 【方法】 将32只Wistar大白鼠,随机分为A65380;B65380;C65380;D四组65377;B65380;C65380;D三组分别与再灌注前静注生理盐水65380;异搏定65380;能量合剂注射液,以A组为对照65377;测定所有动物血清中ALT,AST和LDH含量,血清和肝组织中超氧化物歧化酶(SOD)65380;丙二醛活性(MDA ...
doaj
目的探讨绞股蓝总皂苷(Gypenosides,GP)对大鼠脑缺血再灌注损伤的保护作用及其机制。方法采用线栓法建立大鼠脑缺血再灌注损伤模型,实验分为假手术组、模型组、血塞通阳性药组(20mg·kg-1)、绞股蓝总皂苷高、中、低剂量组(100、30和10mg·kg-1),观察绞股蓝总皂苷对脑缺血再灌注大鼠神经功能评分、脑组织匀浆中SOD、MDA、NO含量等生化指标及梗死面积变化的影响,同时观察HE病理改变,用免疫组化方法观察绞股蓝总皂苷对Bcl-2、Bax蛋白表达的影响 ...
居立娟, 王云东
doaj
目的探讨针对Fas基因的RNA抑制前后缺血再灌注损伤神经细胞凋亡相关指标的变化。方法NGF诱导PC12细胞为类神经细胞。细胞随机分为对照组、模型组、GFP siRNA组;Fas siRNA组。对照组用完全培养液培养,其他三组细胞制作体外缺血再灌注模型。于制作模型前24小时进行转染。于造模后6h进行Fas、Caspase-3表达检测。24 h进行细胞凋亡相关检测。结果1.凋亡率:模型组细胞(39.13±10.63)明显高于对照组(2.85±0.43),差异有显著性 ...
宋冬晶, 李颖, 邬英全
doaj
[Electroacupuncture improves learning and memory function and promotes hippocampal synaptic regeneration in rats with cerebral ischemia-reperfusion injury]. [PDF]
Lin R, Xia J, Ma X, Li Z.
europepmc +1 more source
[Resveratrol protects barrier function of mouse brain microvascular endothelial cell monolayers with oxygen/glucose deprivation and PM<sub>2.5</sub> exposure by maintaining mitochondrial dynamics balance]. [PDF]
Qin M +9 more
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[Asiaticoside alleviates myocardial ischemia-reperfusion injury in rats by inhibiting NLRP3 inflammasome-mediated pyroptosis]. [PDF]
Bian F +7 more
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[<i>In vitro</i> cultured calculus bovis alleviates cerebral ischemia/reperfusion injury through regulating microglial polarization and inhibiting NLRP3]. [PDF]
Chu T +7 more
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Pharmacological inhibition of ENaC or NCX can attenuate hepatic ischemia-reperfusion injury exacerbated by hypernatremia. [PDF]
Chen Y +6 more
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[Electroacupuncture pretreatment alleviates cerebral ischemia-reperfusion injury in rats by inhibiting ferroptosis through the gut-brain axis and the Nrf2/HO-1 signaling pathway]. [PDF]
Zhang A +6 more
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[Colchicine alleviates myocardial ischemia-reperfusion injury in mice by activating AMPK]. [PDF]
Chen G, Luo S.
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